Serum amyloid-A rather than C-reactive protein is a better predictor of mortality in hemodialysis patients

Tohoku Journal of Experimental Medicine

Volumn 219, Issue 2, 2009, Pages 121-127

  Simic Ogrizovic, Sanja ^a   Dopsaj, Violeta ^a,b   Bogavac Stanojevic, Natasa ^b   Obradovic, Ivana ^a   Stosovic, Milan ^a   Radovic, Milan ^a  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b Faculty of Pharmacy   (Serbia)

Author keywords

Acute phase protein; Cardiovascular disease; Chronic inflammation; Dialysis mortality; Serum amyloid A

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; C REACTIVE PROTEIN; FETUIN A; ION; LIPID; SERUM AMYLOID A;

ADULT; ARTICLE; CAUSE OF DEATH; CHRONIC INFLAMMATION; FEMALE; FOLLOW UP; HEMODIALYSIS PATIENT; HUMAN; HYPERPHOSPHATEMIA; HYPOALBUMINEMIA; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PREDICTION; PROTEIN BLOOD LEVEL; SERBIA;

C-REACTIVE PROTEIN; DEMOGRAPHY; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RENAL DIALYSIS; SERUM AMYLOID A PROTEIN;

EID: 70449673391     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.219.121     Document Type: Article

References (37)

1. Albert, C.M., Ma, J., Rifai, N., Stampfer, M.J. & Ridker, P.M. (2002) Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictor of sudden cardiac death. Circulation, 105, 2595-2599. (Pubitemid 34596034)
2. Arima, H., Kubo, M., Yonemoto, K., Doi, Y., Ninomiya, T., Tanizaki, Y., Hata, J., Matsumura, K., Iida, M. & Kiyohara, Y. (2008) High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arterioscler. Thromb. Vasc. Biol., 28, 1385-1391.
3. Bergstrom, J., Heimburger, O., Lindholm, B. & Quereshi, A.R. (1995) Elevated serum-C reactive protein is strong predictor of increased mortality and low serum albumin in hemodialysis (HD) (abstract). J. Am. Soc. Nephrol., 6, 573.
4. Blake, P. & Daugirdas, P. (1996) Quantification and prescription general principles. In: Replacement of renal function by Dialysis, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch & J.F. Kluwer Academic Publishers, Dordrecht, pp. 619-656.
5. Bland, J.M. & Altman, D.G. (1996) Statistics notes: Transformations, means, and confidence intervals. BMJ, 312, 1079.
6. Cheung, A.K., Sarnak, M.J., Yan, G., Dwyer, J.T., Heyka, R.J., Rocco, M.V., Teehan, B.P. & Levey, A.S. (2000) Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients. Kidney Int., 58, 353-362. (Pubitemid 30429882)
7. Cozzolino, M., Galassi, A., Biondi, M.L., Turri, O., Papagni, S., Mongelli, N., Civita, L., Gallieni, M. & Brancaccio, D. (2006) Serum fetuin-A link inflammation and cardiovascular calcification in hemodialysis patients. Am. J. Nephrol., 26, 423-429.
8. Foley, R.N., Parfrey, P.S. & Sarnak, M.J. (1998) Epidemiology of cardiovascular disease in chronic renal disease. J. Am. Soc. Nephrol., 9 (12 Suppl), S16-S23.
9. Fukumoto, Y., Kishi, T., Tsutsui, H., Yamada, A., Okamatsu, S. & Takeshita, A. (2007) Elevated serum C-reactive protein levels as a predictive indicator for subsequent renal impairment in patients with acute heart failure. Tohoku J. Exp. Med., 213, 361-368.
10. Honda, H., Quereshi, A.R., Heimbürger, O., Barany, P., Wang, K., Pecoits Filho, R., Stenvinkel, P. & Lidholm, B. (2006) Serum albumin, C-reactive protein, interleukin-6, and fetuin-A as a predictors of malnutrition, cardiovascular disease, an mortality in patients with ESRD. Am. J. Kidney Dis., 47, 139-148.
11. Hung, C.Y., Chen, Y.A., Chou, C.C. & Yang, C.S. (2005) Nutritional and inflammatory markers in the prediction of mortality in Chinese hemodialysis patients. Nephron Clin. Pract., 100, 20-26.
12. Iseki, K., Kawazoe, N. & Fukiyama, K. (1993) Serum albumin is a strong predictor of death in chronic dialysis patients. Kidney Int., 44, 115-119. (Pubitemid 23198033)
13. Iseki, K., Tozawa, M., Yoshi, S. & Fukiyama, K. (1999) Serum C-reactive protein (CRP) and risk of death in chronic dialysis patients. Nephrol Dial. Transplant., 14, 1956-1960.
14. Ledue, T.B., Weiner, D.L., Sipe, J.D., Poulin, S.E., Collins, M.F. & Rifai, N. (1998) Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum. Ann. Clin. Biochem., 35, 745-753.
15. Malle, E. & De Beer, F.C. (1996) Human serum amyloid A (SAA) protein: a prominent acute-phase reactant for clinical practice. Eur. J. Clin. Invest., 26, 427-435.
16. Maury, C.P. (1985) Comparative study of serum amyloid A protein and C-reactive protein disease. Clin. Sci. (London), 68, 233-238.
17. Menon, V., Greene, T., Wang, X., Pereira, A.A., Marcovina, S.M., Beck, G.J., Kusek, J.W., Collins, A.J., Levey, A.S. & Sarnak, M.J. (2005) C-reactive protein and albumin is predictors of all-cause and cardiovascular in chronic kidney disease. Kidney Int., 68, 766-772. (Pubitemid 43323132)
18. Metry, G., Stenvinkel, P., Qureshi, A., Carrero, J., Yilmaz, M., Barany, P., Snaedal, S., Heimbürger, O., Lindholm, B. & Suliman, M.E. (2008) Low serum fetuin - A concentration predicts poor outcome only in the presence of inflammation in prevalent haemodialysis patients. Eur. J. Clin. Invest., 38, 804-811.
19. Noordzij, M., Korevaar, J.C., Boeschoten, E.W., Dekker, F.W., Bos, W.J. & Krediet, R.T.; Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD) Study Group. (2005) The Kidney Disease Outcomes Quality Initiative (K/DOQI) Guideline for bone metabolism and disease in CKD: association with mortality in dialysis patients. Am. J. Kidney Dis., 46, 925-932.
20. Owen, W.F. & Lowrie, E.G. (1998) C-reactive protein as an outcome predictor for maintenance hemodialysis patients. Kidney Int., 54, 627-636. (Pubitemid 28357427)
21. Panichi, V., Maggiore, U., Taccola, D., Migliori, M., Rizzaa, G.M., Consani, C., Bertini, A., Sposini, S., Perez-Garcia, R., Rindi, P., Palla, R. & Tetta, C. (2004) Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in hemodialysis patients. Nephrol. Dial Transplant., 19, 1154-1160.
22. Pecoits-Filho, R., Barany, P., Lidhom, B., Heimburger, O. & Stenvinkel, P. (2002) Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol. Dial Transplant., 17, 1684-1688.
23. Pecoits-Filho, R., Lindholm, B. & Stenvinkel, P. (2002) The malnutrition, inflammation, and atherosclerosis (MIA) syndrome- the heart of the metier. Nephrol. Dial. Transplant., 17 (Suppl 11), 28-31.
24. Schafer, C., Heiss, A., Schwarz, A., Westenfeld, R., Ketteler, M., Floege, J., Muller-Esterl, W., Schinke, T. & Jahnen-Dechent, W. (2003) The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a sy stemically acting inhibitor of ectopic calcification. J. Clin. Invest., 112, 357-366.
25. Simic-Ogrizovic, S., Stosovic, M., Novakovic, I., Pejanovic, S., Jemcov, T., Radovic, M. & Djukanovic, L.J. (2006) Fuzzy role of hyperhomocysteinemia in hemodialysis pateints' mortality. Biomed. Pharmacother., 60, 200-207.
26. Stenvinkel, P. (2006) Inflammation in end-stage renal disease: The hidden enemy. Nephrology, 11, 36-41.
27. Stenvinkel, P. & Alvestrand, A. (2002) Inflammation in end-stage renal disease: sources, consequences, and therapy. Semin. Dial., 15, 329-337.
28. Stenvinkel, P., Ketteler, M., Johnson, R.J., Lindholm, B., Pecoits- Filho, R., Riella, M., Heimbürger, O., Cederholm, T. & Girndt, M. (2005) Interleukin-10, IL-6 and TNF-α: central factors in the altered cytokine network of uremia - the good, the bad, and the ugly. Kidney Int., 67, 1216-1233.
29. Stenvinkel, P., Wanner, C., Metzger, T., Heimbürger, O., Mallamaci, F., Tripepi, G., Malatino, L. & Zoccali, C. (2002) Inflammation and outcome in end-stage renal failure: does female gender constitute a survival advantage? Kidney Int, 62, 1791-1798.
30. Tsirpanlis, G., Bagos, P., Ioannou, D., Bleta, A., Marinou, I., Lagouranis, A., Chatzipanagiotou, S. & Nicolaou, C. (2004) Exploring inflammation in hemodialysis patients: persistent and superimposed inflammation. A longitudinal study. Kidney Blood Press. Res., 27, 63-70.
31. Wald, R., Sarnak, M.J., Tighiouart, H., Cheung, A.K., Levey, A.S., Eknoyan, G. & Miskulin, D.C. (2008) Disordered mineral metabolism in hemodialysis patients: an analysis of cumulative effects in the Hemodialysis (HEMO) Study. Am. J. Kidney Dis., 52, 531-540.
32. Wang, A.Y., Woo, J., Lam, C.W., Wang, M., Chan, I.H., Gao, P., Lui, S.F., Li, P.K. & Sanderson, J.E. (2005) Association of serum fetuin-A with malnutrition, inflammation, atherosclerosis and vascular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial. Transplant., 20, 1676-1685.
33. Wang, A.Y., Woo, J., Wang, M., Sea, M.M., Ip, R., Li, P.K., Lui, S.F. & Sanderson, J.E. (2001) Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis. J. Am. Soc. Nephrol., 12, 1927-1936.
34. Yuen, J.Y. & Kaysen, G.A. (1997) Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients. Am. J. Kidney Dis., 30, 923-927.
35. Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, S. & Wanner, C. (1999) Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int., 55, 648-658. (Pubitemid 29082891)
36. Zoccali, C., Enia, G., Tripepi, G., Panuccio, V. & Mallamaci, F. (2005) Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients. Perit. Dial. Int., 25 (Suppl 3), S84-S87.
37. Zoccali, C., Mallamaci, F. & Tripepi, G. (2004) Inflammatory proteins as predictors of cardiovascular disease in patients end- stage disease. Nephrol. Dial. Transplant., 19 (Suppl 5), v67-v72.