Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B

Revista do Instituto de Medicina Tropical de Sao Paulo

Volumn 51, Issue 5, 2009, Pages 261-268

  Da Silva, Luiz Caetano ^a   Da Nova, Maria Luiza ^a   Ono Nita, Suzane Kioko ^a   Pinho, João Renato Rebello ^a   Sitnik, Roberta ^a   Dos Santos, Vera Aparecida ^a   Carrilho, Flair José ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hepatitis B; Serological markers; Treatment follow up; Treatment response

Indexed keywords

ADEFOVIR; ALPHA INTERFERON; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; LOBUCAVIR; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; TENOFOVIR; VIRUS DNA;

ADOLESCENT; ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL ARTICLE; DRUG WITHDRAWAL; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; KINETICS; MALE; PATIENT MONITORING; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SEROLOGY; TREATMENT DURATION; TREATMENT RESPONSE; VIRUS CHARACTERIZATION; VIRUS DETECTION; VIRUS LOAD;

ADULT; AGED; ANTIVIRAL AGENTS; CHILD; DNA, VIRAL; DRUG RESISTANCE, VIRAL; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; RETREATMENT; VIRAL LOAD; YOUNG ADULT;

EID: 70449673114     PISSN: 00364665     EISSN: 16789946     Source Type: Journal    
DOI: 10.1590/S0036-46652009000500005     Document Type: Article

References (35)

1. ALBERTI, A. - Can serum HBV-DNA be used as a primary end point to assess efficacy of new treatments for chronic hepatitis B? Hepatology, 38: 18-20, 2003.
2. BUTI, M.; CASADO, M.A. & ESTEBAN, R. - Evaluating the cost of sustained virologic response in naive chronic hepatitis C patients treated a la carte. Aliment. Pharmacol. Ther., 26: 705-716, 2007. (Pubitemid 47246206)
3. CHANG, T.T.; GISH, R.G.; DE MAN, R. et al. - A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. New Engl. J. Med., 354: 1001-1010, 2006. (Pubitemid 43357804)
4. CONJEEVARAM, H.S. & LOK, A.S. - Management of chronic hepatitis B. J. Hepat., 38 (suppl. 1): S90-S103, 2003.
5. CORDEN, S.; BALLARD, A.L.; IJAZ, S. et al. - HBV DNA levels and transmission of hepatitis B by health care workers. J. clin. Virol., 27: 52-58, 2003. (Pubitemid 36519155)
6. DA SILVA, L.C.; DA FONSECA, L.E.; CARRILHO, F.J. et al. - Predictive factors for response to lamivudine in chronic hepatitis B. Rev. Inst. Med. trop. S. Paulo, 42: 189-196, 2000. (Pubitemid 30681494)
7. DA SILVA, L.C.; ONO-NITA, S.K.; PINHO, J.R. & CARRILHO, F.J. - Variable and unpredictable outcome in chronic hepatitis B (CHB) patients during and after therapy with high daily doses of lamivudine (LAM). Hepatology, 36: 638A, 2002.
8. DA SILVA, L.C.; PINHO, J.R.; SITNIK, R.; DA FONSECA, L.E. & CARRILHO, F.J. - Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B. J. Gastroent., 36: 476-485, 2001.
9. DIENSTAG, J.L.; PERRILLO, R.P.; SCHIFF, E.R. et al. - A preliminary trial of lamivudine for chronic hepatitis B infection. New Engl. J. Med., 333: 1657-1661, 1995. (Pubitemid 26001954)
10. FRIED, M.W.; PIRATVISUTH, T.; LAU, G.K. et al. - HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology, 47: 428-434, 2008.
11. FUNG, S.K. & LOK, A.S. - Treatment of chronic hepatitis B: who to treat, what to use, and for how long? Clin. Gastroent. Hepat., 2: 839-848, 2004.
12. HEIJTINK, R.A.; JANSSEN, H.L.; HOP, W.C.; OSTERHAUS, A.D. & SCHALM, S.W. - Interferon-alpha therapy in chronic hepatitis B: early monitoring of hepatitis B e antigen may help to decide whether to stop or to prolong therapy. J. viral Hepat., 7: 382-386, 2000.
13. HEIJTINK, R.A.; KRUINING, J.; HONKOOP, P. et al. - Serum HBeAg quantitation during antiviral therapy for chronic hepatitis B. J. med. Virol., 53: 282-287, 1997. (Pubitemid 28201840)
14. HO, S.K.; YAM, W.C.; LEUNG, E.T. et al. - Rapid quantification of hepatitis B virus DNA by real-time PCR using fluorescent hybridization probes. J. med. Microbiol., 52: 397-402, 2003. (Pubitemid 36589165)
15. HONKOOP, P.; DE MAN, R.A.; NIESTERS, H.G. et al. - Quantitative hepatitis B virus DNA assessment by the limiting-dilution polymerase chain reaction in chronic hepatitis B patients: evidence of continuing viral suppression with longer duration and higher dose of lamivudine therapy. J. viral. Hepat., 5: 307-312, 1998. (Pubitemid 28440325)
16. JARDI, R.; RODRIGUEZ, F.; BUTI, M. et al. - Quantitative detection of hepatitis B virus DNA in serum by a new rapid real-time fluorescence PCR assay. J. viral Hepat., 8: 465-471, 2001.
17. KANEKO, S.; FEINSTONE, S.M. & MILLER, R.H. - Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J. clin. Microbiol., 27: 1930-1933, 1989.
18. KANEKO, S, MILLER, R.H.; DI BISCEGLIE, A.M. et al. - Detection of hepatitis B virus DNA in serum by polymerase chain reaction. Application for clinical diagnosis. Gastroenterology, 99: 799-804, 1990. (Pubitemid 20243373)
19. KEEFFE, E.B.; DIETERICH, D.T. HAN, S.H. et al. - A treatment algorithm for the management of chronic hepatitis B virus infection in the United States. Clin. Gastroent. Hepat., 2: 87-106, 2004. (Pubitemid 38180462)
20. KEEFFE, E.B.; ZEUZEM, S.; KOFF, R.S. et al. - Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B. Clin. Gastroent. Hepat., 5: 890-897, 2007.
21. KIMURA, T.; OHNO, N.; TERADA, N. et al. - Hepatitis B virus DNA-negative Dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J. biol. Chem., 280: 21713-21719, 2005.
22. LEWIN, S.R.; RIBEIRO, R.M.; WALTERS, T. et al. - Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed. Hepatology, 34: 1012-1020, 2001.
23. LOK, A.S.; HEATHCOTE, E.J. & HOOFNAGLE, J.H. - Management of hepatitis B: 2000 - summary of a workshop. Gastroenterology, 120: 1828-1853, 2001.
24. LOK, A.S. & McMAHON, B.J. - Chronic hepatitis B: update of recommendations. Hepatology, 39: 857-861, 2004.
25. LOK, A.S. & McMAHON, B.J. - Chronic hepatitis B. Hepatology, 45: 507-539, 2007.
26. NEUMANN, A.U. - Hepatitis B viral kinetics: a dynamic puzzle still to be resolved. Hepatology, 42: 249-254, 2005.
27. PARK, N.H.; SHIN, J.W.; PARK, J.H. et al. - Monitoring of HBeAg levels may help to predict the outcomes of lamivudine therapy for HBeAg positive chronic hepatitis B. J. viral Hepat., 12: 216-221, 2005.
28. PERRILLO, R.; MIMMS, L.; SCHECHTMAN, K.; ROBBINS, D. & CAMPBELL, C. - Monitoring of antiviral therapy with quantitative evaluation of HBeAg: a comparison with HBV DNA testing. Hepatology, 18: 1306-1312, 1993.
29. ROKUHARA, A.; TANAKA, E.; MATSUMOTO, A. et al. - Clinical evaluation of a new enzyme immunoassay for hepatitis B virus core-related antigen; a marker distinct from viral DNA for monitoring lamivudine treatment. J. viral Hepat., 10: 324-330, 2003.
30. SHAW, T.; BOWDEN, S. & LOCARNINI, S. - Chemotherapy for hepatitis B: new treatment options necessitate reappraisal of traditional endpoints. Gastroenterology, 123: 2135-2140, 2002.
31. SHIN, J.W.; PARK N.H.; JUNG, S.W. et al. - Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive. Wld J. Gastroent., 12: 6693-6698, 2006. (Pubitemid 44794950)
32. SITNIK, R.; PINHO, J.R.; BERTOLINI, D.A. et al. - Hepatitis B virus genotypes and precore and core mutants in Brazilian patients. J. clin. Microbiol., 42: 2455-2460, 2004. (Pubitemid 38747489)
33. TER BORG, M.J.; VAN ZONNEVELD, M.; ZEUZEM, S. et al. - Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: relation to treatment response. Hepatology, 44: 721-727, 2006.
34. WONG, D.K.; TANAKA, Y.; LAI, C.L. et al. - Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J. clin. Microbiol., 45: 3942-3947, 2007. (Pubitemid 350274874)
35. YOTSUYANAGI, H.; YASUDA, K.; IINO, S. et al. - Persistent viremia after recovery from self-limited acute hepatitis B. Hepatology, 27: 1377-1382, 1998.