Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects

Psychological Medicine

Volumn 39, Issue 10, 2009, Pages 1657-1665

  Kircher, T ^a   Markov, V ^b   Krug, A ^a   Eggermann, T ^b   Zerres, K ^b   Nothen M M ^c   Skowronek, M H ^d   Rietschel, M ^d  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Dysbindin; P1578; Rs1018381; Schizophrenia; Schizotypy

Indexed keywords

DYSBINDIN;

ADULT; ALLELE; ARTICLE; ATTENTION; COGNITION; FEMALE; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HETEROZYGOTE; HUMAN; INTELLIGENCE QUOTIENT; MALE; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PERSONALITY; PERSONALITY TEST; PSYCHOLOGIC ASSESSMENT; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; SINGLE NUCLEOTIDE POLYMORPHISM; VERBAL BEHAVIOR; VERBAL COMMUNICATION; WORKING MEMORY;

ADOLESCENT; ADULT; CARRIER PROTEINS; COGNITION; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PERSONALITY; PERSONALITY INVENTORY; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; YOUNG ADULT;

EID: 70449638419     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291709005388     Document Type: Article

References (64)

1. Angst J, Clayton P (1986). Premorbid personality of depressive, bipolar, and schizophrenic patients with special reference to suicidal issues. Comprehensive Psychiatry 27, 511-532.
2. Avramopoulos D, Stefanis NC, Hantoumi I, Smyrnis N, Evdokimidis I, Stefanis CN (2002). Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Molecular Psychiatry 7, 706-711.
3. Bagby RM, Bindseil KD, Schuller DR, Rector NA, Young LT, Cooke RG, Seeman MV, McCay EA, Joffe R T (1997). Relationship between the five-factor model of personality and unipolar, bipolar and schizophrenic patients. Psychiatry Research 70, 83-94.
4. Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ (2001). Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. Journal of Biological Chemistry 276, 24232-24241.
5. Berenbaum H, Fujita F (1994). Schizophrenia and personality: exploring the boundaries and connections between vulnerability and outcome. Journal of Abnormal Psychology 103, 148-158.
6. Blake DJ, Hawkes R, Benson MA, Beesley PW (1999). Different dystrophin-like complexes are expressed in neurons and glia. Journal of Cell Biology 147, 645-658.
7. Borkenau P, Ostendorf F (1993). The NEO Five-Factor Inventory (NEO-FFI) [NEO Fünf-Faktoren Inventar]. Hogrefe: Göttingen.
8. Brickenkamp R (2002). The d2 Test of Attention [Der Aufmerksamkeits- Belastungstest d2]. Hogrefe: Göttingen.
9. Burdick KE, Goldberg TE, Funke B, Bates JA, Lencz T, Kucherlapati R, Malhotra AK (2007). DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophrenia Research 89, 169-172.
10. Burdick KE, Hodgkinson CA, Szeszko PR, Lencz T, Ekholm JM, Kane JM, Goldman D, Malhotra AK (2005). DISC1 and neurocognitive function in schizophrenia. Neuroreport 16, 1399-1402.
11. Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, Kucherlapati R, Malhotra AK (2006). Genetic variation in DTNBP1 influences general cognitive ability. Human Molecular Genetics 15, 1563-1568.
12. Camisa KM, Bockbrader MA, Lysaker P, Rae LL, Brenner CA, O'Donnell BF (2005). Personality traits in schizophrenia and related personality disorders. Psychiatry Research 133, 23-33.
13. Costa PT, McCrae RR (1992). NEO-PI-R: Professional Manual. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI). Psychological Assessment Resources: Odessa, FL.
14. Costa Jr. PT, McCrae RR (1995). Domains and facets: hierarchical personality assessment using the revised NEO personality inventory. Journal of Personality Assessment 64, 21-50.
15. Coyle JT (2006). Glutamate and schizophrenia: beyond the dopamine hypothesis. Cellular and Molecular Neurobiology 26, 365-384.
16. Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Pimm J, Bass N, Lamb G, Moorey H, Morgan J, Punukollu B, Kandasami G, Kirwin S, Sule A, Quested D, Curtis D, Gurling HM (2007). Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia. Behavioral and Brain Functions 3, 50.
17. Daum I, Graber S, Schugens MM, Mayes AR (1996). Memory dysfunction of the frontal type in normal ageing. Neuroreport 7, 2625-2628.
18. DeRosse P, Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, Kucherlapati R, Malhotra AK (2006). Dysbindin genotype and negative symptoms in schizophrenia. American Journal of Psychiatry 163, 532-534. (Pubitemid 44469399)
19. Digman JM (1990). Personality structure: emergence of the five-factor model. Annual Review of Psychology 41, 417-440.
20. Donohoe G, Morris DW, Clarke S, McGhee KA, Schwaiger S, Nangle JM, Garavan H, Robertson IH, Gill M, Corvin A (2007). Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. Neuropsychologia 45, 454-458. (Pubitemid 44828767)
21. Fanous AH, Neale MC, Gardner CO, Webb BT, Straub RE, O'Neill FA, Walsh D, Riley BP & Kendler KS (2007). Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. Molecular Psychiatry 12, 958-965.
22. Fanous AH, van den Oord EJ, Riley BP, Aggen SH, Neale MC, O'Neill FA, Walsh D, Kendler KS (2005). Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. American Journal of Psychiatry 162, 1824-1832.
23. Funke B, Finn CT, Plocik AM, Lake S, DeRosse P, Kane JM, Kucherlapati R, Malhotra AK (2004). Association of the DTNBP1 locus with schizophrenia in a U.S. population. American Journal of Human Genetics 75, 891-898.
24. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR (1997). Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives of General Psychiatry 54, 159-165.
25. Goldberg TE, Straub RE, Callicott JH, Hariri A, Mattay VS, Bigelow L, Coppola R, Egan MF, Weinberger DR (2006). The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology 31, 2022-2032.
26. Hall J, Whalley HC, Job DE, Baig BJ, McIntosh AM, Evans KL, Thomson PA, Porteous DJ, Cunningham-Owens DG, Johnstone EC, Lawrie SM (2006). A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nature Neuroscience 9, 1477-1478.
27. Hallmayer JF, Kalaydjieva L, Badcock J, Dragovic M, Howell S, Michie PT, Rock D, Vile D, Williams R, Corder EH, Hollingsworth K, Jablensky A (2005). Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit. American Journal of Human Genetics 77, 468-476.
28. Harrison PJ, Weinberger DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Molecular Psychiatry 10, 40-68.
29. Härting C, Markowitsch H, Neufeld H, Calabrese P, Deisinger K (2002). The Wechsler Memory Scale-Revised Edition [Wechlser Gedächtnis Test-Revidierte Fassung]. Hogrefe: Göttingen.
30. Jang KL, Livesley WJ, Vernon PA (1996). Heritability of the big five personality dimensions and their facets: a twin study. Journal of Personality 64, 577-591.
31. Kendler KS, Gruenberg AM, Strauss JS (1981). An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia. II. The relationship between schizotypal personality disorder and schizophrenia. Archives of General Psychiatry 38, 982-984.
32. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D (1993). The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Archives of General Psychiatry 50, 527-540. (Pubitemid 23203564)
33. Kirov G, Ivanov D, Williams NM, Preece A, Nikolov I, Milev R, Koleva S, Dimitrova A, Toncheva D, O'Donovan MC, Owen MJ (2004). Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological Psychiatry 55, 971-975.
34. Krabbendam L, Janssen I, Bak M, Bijl RV, de Graaf R, van Os J (2002). Neuroticism and low self-esteem as risk factors for psychosis. Social Psychiatry and Psychiatric Epidemiology 37, 1-6.
35. Lehrl S (2005). Multiple-choice Vocabulary Intelligence Test [Der Mehrfachwahl-Wortschatz-Intelligenztest]. Hogrefe: Göttingen.
36. LiD, He L (2007). Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: a meta-analysis. Schizophrenia Research 96, 112-118. (Pubitemid 47494624)
37. Lin HF, Liu YL, Liu CM, Hung SI, Hwu HG, Chen WJ (2005). Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents. Psychological Medicine 35, 1589-1598.
38. Maier W, Minges J, Lichtermann D, Heun R, Franke P (1994). Personality variations in healthy relatives of schizophrenics. Schizophrenia Research 12, 81-88.
39. Mutsuddi M, Morris DW, Waggoner SG, Daly MJ, Scolnick EM, Sklar P (2006). Analysis of high-resolution HapMap of DTNBP1 (dysbindin) suggests no consistency between reported common variant associations and schizophrenia. American Journal of Human Genetics 79, 903-909.
40. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R (2004). Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Human Molecular Genetics 13, 2699-2708.
41. O'Tuathaigh CM, Babovic D, O'Meara G, Clifford JJ, Croke DT, Waddington JL (2007). Susceptibility genes for schizophrenia: characterization of mutant mouse models at the level of phenotypic behavior. Neuroscience and Biobehavioral Reviews 31, 60-78.
42. Owen MJ, O'Donovan MC, Gottesman II (2002). Schizophrenia. In Psychiatric Genetics and Genomics (ed. P. McGuffin, M. J. Owen and I. I. Gottesman), pp. 247-266. Oxford Medical Publishers: Oxford.
43. Owen MJ, Williams NM, O'Donovan MC (2004a). Dysbindin-1 and schizophrenia: from genetics to neuropathology. Journal of Clinical Investigation 113, 1255-1257.
44. Owen MJ, Williams NM, O'Donovan MC (2004b). The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9, 14-27.
45. Posthuma D, Luciano M, Geus EJ, Wright MJ, Slagboom PE, Montgomery GW, Boomsma DI, Martin NG (2005). A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. American Journal of Human Genetics 77, 318-326.
46. Raine A, Benishay D (1995). The SPQ-B: a brief screening instrument for schizotypal personality disorder. Journal of Personality Disorder 9, 346-355.
47. Reitan RM, Wolfson D (1985). The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Neuropsychology Press: Tucson, AZ.
48. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, Lerer B, Rietschel M, Trixler M, Maier W, Wildenauer DB (2003). Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. American Journal of Human Genetics 72, 185-190.
49. Smyrnis N, Avramopoulos D, Evdokimidis I, Stefanis CN, Tsekou H, Stefanis NC (2007). Effect of schizotypy on cognitive performance and its tuning by COMT val158met genotype variations in a large population of young men. Biological Psychiatry 61, 845-853.
50. Spitzer RL, Endicott J, Gibbon M (1979). Crossing the border into borderline personality and borderline schizophrenia. The development of criteria. Archives of General Psychiatry 36, 17-24.
51. Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, Ioannidis JP, Stefanis CN (2007). Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biological Psychiatry 62, 784-792.
52. Stefanis NC, Van Os J, Avramopoulos D, Smyrnis N, Evdokimidis I, Hantoumi I, Stefanis CN (2004). Variation in catechol-O-methyltransferase val158met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biological Psychiatry 56, 510-515.
53. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS (2002). Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. American Journal of Human Genetics 71, 337-348.
54. Strom TM, Wienker TF (2005). Case-control studies. Tests for deviation from Hardy-Weinberg equilibrium and tests for association (http://ihg2. helmholtz-muenchen.de/cgi-bin/hw/hwa1.pl).
55. Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, Hahn CG, Siegel SJ, Trojanowski JQ, Gur RE, Blake DJ, Arnold SE (2004). Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. Journal of Clinical Investigation 113, 1353-1363.
56. Tang JX, Zhou J, Fan JB, Li XW, Shi YY, Gu NF, Feng GY, Xing YL, Shi JG, He L (2003). Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Molecular Psychiatry 8, 717-718.
57. Torgersen S, Edvardsen J, Oien PA, Onstad S, Skre I, Lygren S, Kringlen E (2002). Schizotypal personality disorder inside and outside the schizophrenic spectrum. Schizophrenia Research 54, 33-38.
58. Tosato S, Ruggeri M, Bonetto C, Bertani M, Marrella G, Lasalvia A, Cristofalo D, Aprili G, Tansella M, Dazzan P, Diforti M, Murray RM, Collier DA (2007). Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B, 647-659.
59. Van Den Bogaert A, Schumacher J, Schulze TG, Otte AC, Ohlraun S, Kovalenko S, Becker T, Freudenberg J, Jonsson EG, Mattila-Evenden M, Sedvall GC, Czerski PM, Kapelski P, Hauser J, Maier W, Rietschel M, Propping P, Nothen MM, Cichon S (2003). The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. American Journal of Human Genetics 73, 1438-1443.
60. van den Oord EJ, Sullivan PF, Jiang Y, Walsh D, O'Neill FA, Kendler KS, Riley BP (2003). Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. Molecular Psychiatry 8, 499-510.
61. Wechsler D (1997). Wechsler Memory Scale: Administration and Scoring Manual. The Psychological Corporation/Harcourt Brace & Co.: San Antonio.
62. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR, Kleinman JE (2004). Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Archives of General Psychiatry 61, 544-555.
63. Williams NM, O'Donovan MC, Owen MJ (2005). Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophrenia Bulletin 31, 800-805.
64. Zinkstok JR, de Wilde O, van Amelsvoort TA, Tanck MW, Baas F, Linszen DH (2007). Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behavioral and Brain Functions 3, 19.