Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion

Peptides

Volumn 30, Issue 12, 2009, Pages 2380-2387

  Burden Gulley, Susan M ^a   Gates, Theresa J ^a   Craig, Sonya E L ^a   Lou, Sara F ^a   Oblander, Samantha A ^a   Howell, Scott ^a   Gupta, Mukur ^b   Brady Kalnay, Susann M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Adherex Technologies Inc   (United States)

Author keywords

Adhesion; N cadherin; Neurite outgrowth; Peptidomimetic; Small molecules

Indexed keywords

ADH 1; ADH 200024; ADH 200402; ADH 200404; ADH 200474; ADH 200540; ADH 200553; ADH 200718; ADH 200782; EXHERIN; NERVE CELL ADHESION MOLECULE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CHICK; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; IC 50; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; CADHERINS; CELL ADHESION; CELL LINE, TUMOR; CHICKENS; GLIOBLASTOMA; HUMANS; MICE; NEURITES; PEPTIDES; RATS;

HEPATITIS A VIRUS;

EID: 70449627022     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.09.013     Document Type: Article

References (31)

1. Agiostratidou G., Hulit J., Phillips G.R., and Hazan R.B. Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression. J Mammary Gland Biol Neoplasia 12 (2007) 127-133
2. Augustine C.K., Yoshimoto Y., Gupta M., Zipfel P.A., Selim M.A., Febbo P., et al. Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. Cancer Res 68 (2008) 3777-3784
3. Barami K., Lewis-Tuffin L., and Anastasiadis P.Z. The role of cadherins and catenins in gliomagenesis. Neurosurg Focus 21 (2006) E13
4. Blaschuk O.W., Sullivan R., David S., and Pouliot Y. Identification of a cadherin cell adhesion recognition sequence. Dev Biol 139 (1990) 227-229
5. Brock J.H., Elste A., and Huntley G.W. Distribution and injury-induced plasticity of cadherins in relationship to identified synaptic circuitry in adult rat spinal cord. J Neurosci 24 (2004) 8806-8817
6. Burden-Gulley S.M., and Brady-Kalnay S.M. PTPmu regulates N-cadherin-dependent neurite outgrowth. J Cell Biol 144 (1999) 1323-1336
7. Burgoyne A.M., Palomo J.M., Phillips-Mason P.J., Burden-Gulley S.M., Major D.L., Zaremba A., et al. PTPmu suppresses glioma cell migration and dispersal. Neuro Oncol (2009) March 20, 2009 Epub ahead of print
8. Deumens R., Joosten E.A., Waxman S.G., and Hains B.C. Locomotor dysfunction and pain: the scylla and charybdis of fiber sprouting after spinal cord injury. Mol Neurobiol 37 (2008) 52-63
9. Erez N., Zamir E., Gour B.J., Blaschuk O.W., and Geiger B. Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. Exp Cell Res 294 (2004) 366-378
10. Gumbiner B.M. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 6 (2005) 622-634
11. Halbleib J.M., and Nelson W.J. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev 20 (2006) 3199-3214
12. Hamburger V., and Hamilton H.L. A series of normal stages in the development of the chick embryo. 1951. Dev Dyn 195 (1992) 231-272
13. Hazan R.B., Phillips G.R., Qiao R.F., Norton L., and Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 148 (2000) 779-790
14. Hazan R.B., Qiao R., Keren R., Badano I., and Suyama K. Cadherin switch in tumor progression. Ann N Y Acad Sci 1014 (2004) 155-163
15. Hoschouer E.L., Yin F.Q., and Jakeman L.B. L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury. Exp Neurol 216 (2009) 22-34
16. Kalous A., Osborne P.B., and Keast J.R. Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. J Comp Neurol 504 (2007) 238-253
17. Lagenaur C., and Lemmon V. An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc Natl Acad Sci USA 84 (1987) 7753-7757
18. Milne G.W., Nicklaus M.C., Driscoll J.S., Wang S., and Zaharevitz D. National Cancer Institute Drug Information System 3D database. J Chem Inf Comput Sci 34 (1994) 1219-1224
19. Nakajima S., Doi R., Toyoda E., Tsuji S., Wada M., Koizumi M., et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 10 (2004) 4125-4133
20. Nieman M.T., Prudoff R.S., Johnson K.R., and Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 147 (1999) 631-644
21. Nose A., Tsuji K., and Takeichi M. Localization of specificity determining sites in cadherin cell adhesion molecules. Cell 61 (1990) 147-155
22. Oblander S.A., Ensslen-Craig S.E., Longo F.M., and Brady-Kalnay S.M. E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Mol Cell Neurosci 34 (2007) 481-492
23. Perotti A., Sessa C., Mancuso A., Noberasco C., Cresta S., Locatelli A., et al. Clinical and pharmacological phase I evaluation of Exherin (ADH-1), a selective anti-N-cadherin peptide in patients with N-cadherin-expressing solid tumours. Ann Oncol 20 (2009) 741-745
24. Pokutta S., and Weis W.I. Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol 23 (2007) 237-261
25. Redies C., and Takeichi M. N- and R-cadherin expression in the optic nerve of the chicken embryo. Glia 8 (1993) 161-171
26. Shintani Y., Fukumoto Y., Chaika N., Grandgenett P.M., Hollingsworth M.A., Wheelock M.J., et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer 122 (2008) 71-77
27. Skaper S.D. Neuronal growth-promoting and inhibitory cues in neuroprotection and neuroregeneration. Ann N Y Acad Sci 1053 (2005) 376-385
28. Takeichi M. The cadherin superfamily in neuronal connections and interactions. Nat Rev Neurosci 8 (2007) 11-20
29. Wanner I.B., and Wood P.M. N-cadherin mediates axon-aligned process growth and cell-cell interaction in rat Schwann cells. J Neurosci 22 (2002) 4066-4079
30. Wheelock M.J., Shintani Y., Maeda M., Fukumoto Y., and Johnson K.R. Cadherin switching. J Cell Sci 121 (2008) 727-735
31. Williams E., Williams G., Gour B.J., Blaschuk O.W., and Doherty P. A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif. J Biol Chem 275 (2000) 4007-4012