A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 5018-5022

  Sheridan, H ^a   Walsh, J J ^a   Jordan, M ^a   Cogan, C ^a   Frankish, N ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Asthma; Indane dimers; Mast cell stabilising activity; Smooth muscle relaxation

Indexed keywords

2 [2,3 DIHYDRO 2 (1H INDEN 3 YL) 1 OXO 1H INDEN 2 YL]ACETIC ACID; 2 ALLYL 2,3 DIHYDRO 2 (1H INDEN 3 YL) 1H INDEN 1 OL; 2 BENZYL 2, DIHYDRO 2 (1H INDEN 3 YL)INDEN 1 ONE; 2,3 DIHYDRO 2 (1H INDEN 3 YL) 2 (PENT 2 ENYL) 1H INDEN 1 OL; 2,3 DIHYDRO 2 (1H INDEN 3 YL) 2 METHYLINDEN 1 ONE; 2,3 DIHYDRO 2 (1H INDEN 3 YL) 2 PROPYL 1H INDEN 1 OL; 2,3 DIHYDRO 2 (1H INDEN 3 YL) 2 PROPYLINDEN 1 ONE; 3 DIHYDRO 2 (1H INDEN 3 YL) 2 ETHYLINDEN 1 ONE; 3 DIHYDRO 2 (1H INDEN 3 YL) 2 PENTYLINDEN 1 ONE; 3 DIHYDRO 2 (1H INDEN 3 YL) 2 PROPYLINDEN 1 ONE; ANTIASTHMATIC AGENT; CROMOGLYCATE DISODIUM; HISTAMINE; INDAN DERIVATIVE; METHYL 2 [2,3 DIHYDRO 2 (1H INDEN 3 YL) 1 OXO 1H INDEN 2 YL]ACETATE; METHYL 4 [[2,3 DIHYDRO 2 (1H INDEN 3 YL) 1 OXO 1H INDEN 2 YL]METHYL]BENZOATE; NIFEDIPINE; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG SYNTHESIS; HISTAMINE METABOLISM; ILEUM CONTRACTION; IMMUNOMODULATION; MAST CELL; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; SMOOTH MUSCLE RELAXATION;

ANIMALS; DIMERIZATION; FEMALE; GUINEA PIGS; ILEUM; INDANS; MALE; MAST CELLS; MOLECULAR STRUCTURE; MUSCLE RELAXATION; MUSCLE, SMOOTH;

EID: 70449624830     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.09.005     Document Type: Article

References (15)

1. Mitsutake S., and Igarashi Y. J. Biol. Chem. 280 (2005) 40436-40441
2. Mitsutake S., Kim T.J., Inagaki Y., Kato M., Yamashita T., and Igarashi Y. J. Biol. Chem. 279 (2004) 17570-17577
3. Baumruker T., Bornancin F., and Billich A. Immunol. Lett. 96 (2005) 175-185
4. Kim J.W., Inagaki Y., Mitsutake S., Maezawa N., Katsumura S., Ryu Y.W., Park C.S., Taniguchi M., and Igarashi Y. Biochim. Biophys. Acta. 1738 (2005) 82-90
5. Gomes B., Cabral M.D., Gallard A., Savignac M., Paulet P., Druet P., Mariame B., Moreau M., Leclerc C., Guery J.C., and Pelletier L. Am. J. Respir. Crit. Care Med. 175 (2007) 1117-1124
6. Ho S.T., Yang M.S., Wu T.S., and Wang C.H. Planta. Med. 51 (1985) 148-150
7. Buckle D.R., Morgan N.J., Ross J.W., Smith H., and Spicer B.A. J. Med. Chem. 16 (1973) 1334-1339
8. J. Walsh, N. Frankish, H. Sheridan, W. Byrne: New dimeric indane derivatives - are used as smooth muscle relaxants, mast cell stabilisers and antiinflammatory agents. For treating asthma or allergies, VENANTIUS LTD (VENA-Non-standard) 2002 874800-A874801.
9. Sheridan H., Frankish N., and Farrell R. Eur. J. Med. Chem. 34 (1999) 953-966
10. Sheridan H., Frankish N., and Farrell R. Planta. Med. 65 (1999) 271-272
11. Sheridan H., Lemon S., Frankish N., McArdle P., Higgins T., James J.P., and Bhandari P. Eur. J. Med. Chem. 25 (1990) 603-608
12. Farrell R., Kelleher F., and Sheridan H. J. Nat. Prod. 59 (1996) 446-447
13. Frankish N., Farrell R., Sheridan H., and Pharm J. Pharmacology 56 (2004) 1423-1427
14. H. Sheridan, J J. Walsh, C. Cogan, M. Jordan, T.McCabe, E. Passante, N.H. Frankish, Bioorg. Med. Chem. Lett. 19 (2009) 5927-5930.
15. Murthy K.S. Annu. Rev. Physiol. 68 (2006) 345-374