A seamless phase II/III design with sample-size re-estimation

Journal of Biopharmaceutical Statistics

Volumn 19, Issue 4, 2009, Pages 595-609

  Bischoff, Wolfgang ^a   Miller, Frank ^b  

^a CATHOLIC UNIVERSITY OF EICHSTÄTT INGOLSTADT   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Adaptive design; Bayes procedure; Clinical trial; Expected number of patients; Group sequential test; Seamless phase II III trial; Two stage design; Unknown variance

Indexed keywords

ARTICLE; ASSAY; CALCULATION; OBSERVATION; PARAMETER; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; SAMPLE SIZE; VARIANCE;

ANALYSIS OF VARIANCE; BAYES THEOREM; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; DATA INTERPRETATION, STATISTICAL; HUMANS; MODELS, STATISTICAL; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 70449623272     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543400902963193     Document Type: Article

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