A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy

Epilepsy and Behavior

Volumn 16, Issue 4, 2009, Pages 609-616

  McVearry, Kelly M ^a   Gaillard, William D ^a   VanMeter, John ^a   Meador, Kimford J ^b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiepileptic drugs; Carbamazepine; Cognitive fluency; Cognitive teratogens; Fluid intelligence; Lamotrigine; Pharmacovigilance in fetal drug exposure; Pregnancy and epilepsy; Prenatal exposure and child development; Valproate

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; VALPROIC ACID;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CHILD; COGNITION; CONTROLLED STUDY; EPILEPSY; FEMALE; FLUENCY DISORDER; HUMAN; INTELLIGENCE; MAJOR CLINICAL STUDY; MALE; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PRESCHOOL CHILD; PROSPECTIVE STUDY; RISK FACTOR; STATISTICAL ANALYSIS;

ANALYSIS OF VARIANCE; ANTICONVULSANTS; CARBAMAZEPINE; CHILD, PRESCHOOL; COGNITION; CREATIVENESS; EPILEPSY; FEMALE; HUMANS; INTELLIGENCE TESTS; MALE; NEUROPSYCHOLOGICAL TESTS; PATIENT SELECTION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; TRIAZINES; VALPROIC ACID;

EID: 70449533652     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.09.024     Document Type: Article

References (54)

1. Meador K. Anatomical and behavioral effects of in utero exposure to antiepileptic drugs. Epilepsy Curr 5 (2005) 212-216
2. Ardinger H.H., Atkin J.F., and Blackston R.D. Verification of the fetal valproate syndrome phenotype. Am J Med Genet 29 (1988) 171-185
3. Christianson A.L., Chesler N., and Kromberg J.G. Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Dev Med Child Neurol 36 (1994) 361-369
4. Meador K.J., Baker G.A., and Finnell R.H. In utero antiepileptic drug exposure: fetal death and malformations. Neurology 67 (2006) 407-412
5. Meador K. Cognitive deficits from in utero AED exposure. Epilepsy Curr 4 (2004) 196-197
6. Eriksson K., Viinikainen K., and Monkkonen A. Children exposed to valproate in utero: population based evaluation of risks and confounding factors for long-term neurocognitive development. Epilepsy Res 65 (2005) 189-200
7. Meador K.J., Baker G.A., Browning N., et al., for the NEAD Study Group. Fetal antiepileptic drug exposure and cognitive function at age 3. N Engl J Med 360 (2009) 1597-1605
8. Gaily E., Kantola-Sorsa E., and Hiilesmaa V. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology 62 (2004) 28-32
9. Adab N., Jacoby A., and Smith D. Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 70 (2001) 15-21
10. Adab N., Kini V., and Vinten J. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 75 (2004) 1575-1583
11. Rasalam A.D., Hailey H., and Williams J.H. Characteristics of fetal anticonvulsant syndrome associated autistic disorder. Dev Med Child Neurol 47 (2005) 551-555
12. Williams P.G., and Hersh J.H. A male with fetal valproate syndrome and autism. Dev Med Child Neurol 39 (1997) 632-634
13. Williams G., King J., and Cunningham M. Fetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol 43 (2001) 202-206
14. McVearry K, Brost D, VanMeter J, Meador K. Environmental toxicology and risk assessment for autism phenotypes: a prospective study of children exposed in utero to antiepileptic drugs. Presented at the International Meeting for Autism Researchers, London; 2008.
15. Meador K.J., Baker G., and Cohen M.J. Cognitive/behavioral teratogenetic effects of antiepileptic drugs. Epilepsy Behav 11 (2007) 292-302
16. Meador K.M., Reynolds M.W., Crean S., Fahrbach K., and Probst C. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 81 (2008) 1-13
17. Weschler D. Weschler intelligence scale for children-III (1991), Psychological Corp., San Antonio, TX
18. Weschler D. Weschler preschool and primary scale of intelligence (1967), Psychological Corp., Cleveland, OH
19. Weschler D. Weschler intelligence scale for children-revised. 1974.
20. Elliot C.D. Differential ability scales (1990), Psychological Corp., San Antonio, TX
21. Bayley N. Bayley scales of infant development. 2nd ed. (1993), Psychological Corp., San Antonio, TX
22. Brown L. Test of nonverbal intelligence. 3rd ed. (1997), Pro-Ed., Austin, TX
23. Weschler D. Weschler adult intelligence scale-III (1997), Psychological Corp., San Antonio, TX
24. Torrance E.P. Thinking creatively in action and movement (1981), Scholastic Testing Service, Inc., Bensenville
25. Renzulli J. The ninth mental measurements yearbook, Buros Institute of Mental Measurement (1985), Univ. of Nebraska Press, Lincoln
26. Davis J. The golden age of creativity: the U-shaped curve of child development (1999), Harvard Graduate School of Education, Cambridge
27. Davis J. Drawing's demise: U-shaped development in graphic symbolization. Studies in Art Ed 38 (1997) 132-157
28. Torrance EP, Fortson LR, Orcutt LE. The creative-aesthetic approach to school readiness and measured creative growth. Athens, GA: Georgia University Report BR-5-0250;1967.
29. JMP IN 5.1.2. Cary, NC: SAS Institute; 1994.
30. SAS Version 9.1. Cary, NC: SAS Institute; 2003.
31. Bittigau P., Sifringer M., and Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann NY Acad Sci 993 (2003) 103-114 discussion 123-124
32. Olney J.W., Wozniak D.F., and Jevtovic-Todorovic V. Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol 12 (2002) 488-498
33. Bittigau P., Sifringer M., and Genz K. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 99 (2002) 15089-15094
34. Ikonomidou C., Koch C., and Olney J.W. Neurotransmitters and apoptosis in the developing brain. Biochem Pharmacol 62 (2001) 401-405
35. Hall A.C., Brennan A., Goold R.G., et al. Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Mol Cell Neurosci 20 (2002) 257-270
36. Williams R.S., et al. A common mechanism of action for three mood-stabilizing drugs. Nature 417 (2002) 292-295
37. Shimshoni J.A., et al. The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol Pharmacol 71 (2007) 884-892
38. Shaltiel G., Dalton E.C., Belmaker R.H., et al. Specificity of mood stabilizer action on neuronal growth cones. Bipolar Disord 9 (2007) 281-289
39. Rallu M., Corbin J.G., and Fishell G. Parsing the prosencephalon. Nat Rev Neurosci 3 (2002) 943-951
40. O'Rahilly R., and Mèuller F. The embryonic human brain: an atlas of developmental stages. 3rd ed. (2006), Wiley-Liss, Hoboken, NJ p. ix
41. Duncan J., Burgess P., and Emslie H. Fluid intelligence after frontal lobe lesions. Neuropsychologia 33 (1995) 261-268
42. Duncan J., et al. Intelligence and the frontal lobe: the organization of goal-directed behavior. Cogn Psychol 30 (1996) 257-303
43. Gonzalez C.L., Whishaw I.Q., and Kolb B. Complete sparing of spatial learning following posterior and posterior plus anterior cingulate cortex lesions at 10 days of age in the rat. Neuroscience 122 (2003) 563-571
44. Rice D., and Barone Jr. S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108 Suppl. 3 (2000) 511-533
45. Shaw P., Kabani N.J., Lerch J.P., et al. Neurodevelopmental trajectories of the human cerebral cortex. J Neurosci 28 (2008) 3586-3594
46. Sowell E.R., Peterson B.S., and Toga A.W. Mapping cortical change across the human life span. Nat Neurosci 6 (2003) 309-315
47. Dawson G., and Fischer K.W. Human behavior and the developing brain (1994), Guilford Press, New York p. xxiv
48. 18FDG positron emission tomography. Science 231 (1986) 840-843
49. Chugani H.T., and Phelps M.E. Imaging human brain development with positron emission tomography. J Nucl Med 32 (1991) 23-26
50. Huttenlocher P.R., and Dabholkar A.S. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 387 (1997) 167-178
51. Goodman L.S., Gilman A., and Keith L. Goodman & Gilman's the pharmacological basis of therapeutics. 11th ed. (2006), McGraw-Hill, New York p. xxiii
52. Rogawski M.A., and Loscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 10 (2004) 685-692
53. Gardner H. Creating minds: an anatomy of creativity seen through the lives of Freud, Einstein, Picasso, Stravinsky, Eliot, Graham, and Gandhi (1993), BasicBooks, New York
54. Sternberg R.J. Handbook of creativity (1999), Cambridge Univ. Press, Cambridge/New York