Characterization of a novel impurity in bulk drug eprosartan by ESI/MSn and NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 3, 2010, Pages 778-783

  Sun, Cuirong ^a   Wu, Jianmei ^a   Wang, Danhua ^a   Pan, Yuanjiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Eprosartan; HPLC MSn; NMR; Structural elucidation; Unknown impurity

Indexed keywords

4,4' [5,5' 3,3' [4,4' METHYLENEBIS(THIOPHENE 4,2 DIYL)]BIS(2 CARBOXYPROP 1 ENE 3,1 DIYL)BIS(2 BUTYL 1H IMIDAZOLE 5,1 DIYL)]BIS(METHYLENE)DIBENZOIC ACID; BENZOIC ACID DERIVATIVE; CARBENE; CARBON DIOXIDE; DIMER; EPROSARTAN; PROTON; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DETERMINATION; DRUG IMPURITY; ELECTROSPRAY MASS SPECTROMETRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ACRYLATES; DRUG CONTAMINATION; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOPHENES;

EID: 70449530775     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.050     Document Type: Article

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