Association of alpha 2A adrenergic receptor gene (ADRΑ2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis

Clinica Chimica Acta

Volumn 411, Issue 1-2, 2010, Pages 59-63

  Sikander, Arbab ^a   Rana, Satya Vati ^a   Sharma, Sanjeev K ^a   Sinha, Saroj Kant ^a   Arora, Sunil K ^a   Prasad, Kaushal Kishor ^a   Singh, Kartar ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Alpha 2A adrenoceptor; Genetic polymorphism; Irritable bowel syndrome; Microscopic colitis; Ulcerative colitis

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; GENOMIC DNA; RESTRICTION ENDONUCLEASE;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MICROSCOPIC COLITIS; MUTATIONAL ANALYSIS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; ULCERATIVE COLITIS;

BASE SEQUENCE; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; DNA PRIMERS; HUMANS; IRRITABLE BOWEL SYNDROME; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 70449530423     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.10.003     Document Type: Article

References (57)

1. Walter S.A., Ragnarsson G., and Bodemar G. New criteria for irritable bowel syndrome based on prospective symptom evaluation. Am J Gastroenterol 100 (2005) 2598-2609
2. Camilleri M., and Choi M.G. Review article: irritable bowel syndrome. Aliment Pharmacol Ther 11 (1997) 3-15
3. Mitchell C.M., and Drossman D.A. Survey of the AGA membership relating to patients with functional gastrointestinal disorders. Gastroenterol 92 (1987) 1282-1284
4. Morris-Yates A., Talley N.J., Boyce P.M., Nandurkar S., and Andrews G. Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol 93 (1998) 1311-1317
5. Levy R.L., Jones K.R., Whitehead W.E., Feld S.I., Talley N.J., and Corey L.A. Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterol 121 (2001) 799-804
6. Lembo A., Zaman M.S., Chavez N.F., Crueger R., Jones M.P., and Talley N.J. Concordance of IBS among monozygotic and dizygotic twins. Gastroenterol 120 Suppl. 1 (2001) A81
7. Elsenbruch S., and Orr W.C. Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am J Gastroenterol 96 (2001) 460-466
8. Gupta V., Sheffield D., and Verne G.N. Evidence for autonomic dysregulation in the irritable bowel syndrome. Dig Dis Sci 47 (2002) 1716-1722
9. Tillisch K., Mayer E.A., Labus J.S., Stains J., Chang L., and Naliboff B.D. Sex specific alterations in autonomic function among patients with irritable bowel syndrome. Gut 54 (2005) 1396-1401
10. Aggarwal A., Cutts T.F., Abell T.L., Cardoso S., Familoni B., Bremer J., et al. Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities. Gastroenterol 106 (1994) 945-950
11. Bharucha A.E., Camilleri M., Zinsmeister A.R., and Hanson R.B. Adrenergic modulation of human colonic motor and sensory function. Am J Physiol 36 (1997) G997-G1006
12. Viramontes B.E., Malcolm A., Camilleri M., Szarka L.A., Mckinzie S., Burton D.D., et al. Effects of alpha 2-adrenergic agonist on gastrointestinal transit, colonic motility and sensation in humans. Am J Physiol 281 (2001) G1468-G147613
13. Handy D.E., Flordellis C.S., Bogdanova N.N., Bresnahan M., and Gavras H. Diverse tissue expression of rat alpha 2 adrenergic receptor genes. Hypertension 21 (1993) 861-865
14. Small K.M., McGraw D.W., and Liggett S.B. Pharmacology and physiology of human adrenergic receptor polymorphisms. Ann Rev Pharmacol Toxicol 43 (2003) 381-411
15. Hein L., Altman J.D., and Kobilka B.K. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402 (1999) 181-184
16. Lario S., Calls J., Cases A., Oriola J., Torras A., and Rivera F. MspI identifies a biallelic polymorphism in the promoter region of the alpha 2A-adrenergic receptor gene. Clin Genet 51 (1997) 129-130
17. Garenc C., Perusse L., Chagnon Y.C., Rankinen T., Gagnon J., Borecki I.B., et al. The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Mol Med 8 (2002) 88-94
18. Wang B., Wang Y., Zhou R., Li J., Qian Q., Yang L., et al. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 141 (2006) 130-134
19. Prestes A.P., Marques F.Z., Hutz M.H., Roman T., and Bau C.H. Tobacco smoking and the ADRA2A C-1291G polymorphism. J Neural Transm 114 (2007) 1503-1506
20. Elsenbruch S., Holtmann G., Oezcan D., Lysson A., Janssen O., Goebel M.U., et al. Are there alterations of neuroendocrine and cellular immune responses to nutrients in woman with irritable bowel syndrome. Am J Gastroenterol 99 (2004) 703-710
21. Saunders P.R., Miceli P., Vallance B.A., Wang L., Pinto S., Tougas G., et al. Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat. Autonomic Neuroscience: Basic and Clinical 124 (2006) 56-68
22. Lechin F., van der Dijs B., Insausti C.L., Gómez F., Villa S., Lechin A.E., et al. Treatment of ulcerative colitis with clonidine. J Clin Pharmacol 25 (1985) 219-226
23. Martinolle J.P., Moré J., Dubech N., and Garcia-Villar R. Inverse regulation of alpha and beta adrenoceptor during tri-nitrobenzenesulfonic acid (TNB)-induced inflammation in guinea-pig small intestine. Life Sci 53 (1993) 1499-1508
24. Kyosola K., Penttila O., and Salaspuro M. Rectal mucosal adrenergic innervation and enterocromaffin cells in ulcerative colitis and irritable colon. Scand J Gastroenterol 12 (1977) 363-367
25. Mouzas I.A., Pallis A.G., Kochiadakis G.E., Marketou M., Chlouverakis G.I., Mellisas J., et al. Autonomic imbalance during the day in patients with inflammatory bowel disease in remission. Evidence from spectral analysis of heart rate variability over 24 h. Dig Liver Dis 34 (2002) 775-780
26. Maule S., Pierangeli G., Cevoli S., Grimaldi D., Gionchetti P., Barbara G., et al. Sympathetic hyperactivity in patients with ulcerative colitis. Clin Auton Res 4 (2007) 217-220
27. Nyhlin N., Bohr J., Eriksson S., and Tysk C. Microscopic colitis: a common and an easily overlooked cause of chronic diarrhea. Eur J Intern Med 19 (2008) 181-187
28. Schiller L.R. Diagnosis and management of microscopic colitis syndrome. J Clin Gastroenterol 38 Suppl 5 (2004) S27-S30
29. Rosmond R., Bouchard C., and Bjorntorp P.A. C-1291G polymorphism in the alpha2Aadrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. J Intern Med 251 (2002) 252-259
30. Kim H.J., Camilleri M., Carlson P.J., Cremonini F., Ferber I., Stephens D., et al. Association of distinct alpha (2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 53 (2004) 829-837
31. Thompson W.G., Longstreth G.F., Drossman D.A., Heaton K.W., Irvine E.J., and Muller-Lissner S.A. Functional bowel disorders and functional abdominal pain. Gut 45 2 Suppl (1999) 42II-47II
32. Lennard-Jones J.E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170 (1989) 2-6
33. Tagkalidis P., Bhathal P., and Gibson P. Microscopic colitis. J Gastroenterol Hepatol 17 (2002) 236-248
34. Olesen M., Eriksson S., Bohr J., Järnerot G., and Tysk C. Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998. Gut 53 (2004) 346-350
35. Lahiri D.K., and Nurhberger J.I. A rapid non enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Res 19 (1991) 5444
36. Naliboff B.D., Munakata J., Fullerton S., Gracely R.H., Kodner A., Harraf F., et al. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut 41 (1997) 505-512
37. Ghoshal U.C., Abraham P., Bhatt C., Choudhuri G., Bhatia S.J., Shenoy K.T., et al. Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol 27 (2008) 22-28
38. Hildebrand K.R., Lin G., Murtaugh M.P., and Brown D.R. Molecular characterization of alpha-2-adrenergic receptors regulating intestinal electrolyte transport. Mol Pharmacol 43 (1993) 23-29
39. Liu L., and Coupar I.M. Role of α2-adrenoceptors in the regulation of intestinal water transport. Br J Pharmacol 120 (1997) 892-898
40. Crowell M.D., Harris L., Jones M.P., and Chang L. New insights into the pathophysiology of irritable bowel syndrome: implications for future treatments. Curr Gastroenterol Rep 7 (2005) 272-279
41. Andresen V., and Camilleri M. Irritable bowel syndrome. Recent and novel therapeutic approaches. Drugs 66 (2006) 1073-1088
42. De Ponti F., Giaroni C., Cosentino M., Lecchini S., and Frigo G. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther 69 (1996) 59-78
43. Scheibner J., Trendelenburg A.U., Hein L., Starke K., and Blandizzi C. Alpha 2-Adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-defcient mice. British Journal of Pharmacology 135 (2002) 697-704
44. Camilleri M., Busciglio I., Carlson P., McKinzie S., Burton D., Baxter K., et al. Candidate genes and sensory functions in health and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 295 2 (2008) G219-G225
45. Grudell A.B., Camilleri M., Carlson P., Gorman H., Ryks M., Burton D., et al. An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions. Neurogastroenterol Motil 20 (2008) 213-222
46. Belfer I., Buzas B., Hipp H., Phillips G., Taubman J., Lorincz I., et al. Haplotype-based analysis of α 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. J Hum Genet 50 (2005) 12-20
47. Ohara K., Nagai M., Tani K., Tsukamoto T., Suzuki Y., and Ohara K. Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. Clin Neurosci 9 (1998) 1291-1294
48. Matsunaga T., Yasuda K., Adachi T., Gu N., Yamamura T., Moritani T., et al. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. J Hum Genet 52 (2007) 28-37
49. Tsai S.J., Wang Y.C., Yu Younger W.Y., Lin C.H., Yang K.H., and Hong C.J. Association analysis of polymorphism in the promoter region of the alpha2A-adrenoceptor gene with schizophrenia and clozapine response. Schizophr Res 49 (2001) 53-61
50. Hamann A., Brieske C., Tafel J., Buttron P., Schwarzloh B., Münzberg H., et al. Identification of a deletion variant in the gene encoding the human alpha(2A)-adrenergic receptor. Eur J Endocrinol 144 (2001) 291-295
51. Bolonna A.A., Arranz M.J., Munro J., Osborne S., Petouni M., Martinez M., et al. No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response. Neurosci Lett 280 (2000) 65-68
52. Lima J.J., Feng H., Duckworth L., Wang J., Sylvester J.E., Kissoon N., et al. Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metabolism 56 (2007) 757-765
53. Prestes A.P., Marques F.Z., Hutz M.H., Roman T., and Bau C.H. Tobacco smoking and the ADRA2A C-1291G polymorphism. J Neural Transm 114 (2007) 1503-1506
54. Schmitz M., Denardin D., Silva T.L., Pianca T., Roman T., Hutz M.H., et al. Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type. Biol Psychiatry 60 (2006) 1028-1061
55. Barbezat G., Poulton R., Milne B., Howell S., Fawcett J.P., and Talley N. Prevalence and correlates of irritable bowel symptoms in a New Zealand birth cohort. NZ Med J 115 (2002) U220
56. Rana S.V., Sinha S.K., Sikander A., Bhasin D.K., and Singh K. Study of small intestinal bacterial overgrowth in North Indian patients with irritable bowel syndrome: a case control study. Trop Gastroenterol 29 (2008) 23-25
57. Falodia S., Makharia G.K., Sateesh J., Deo V., Tevatia M.S., and Gupta S.D. Spectrum of microscopic colitis in a tertiary care centre in India. Trop Gastroenterol 28 (2007) 121-125