Fibroblast growth factor 2 requires complex formation with ATP for neuroprotective activity

Neuroscience

Volumn 164, Issue 4, 2009, Pages 1695-1700

  Rose, K ^a   Litterscheid, S ^a   Klumpp, S ^a   Krieglstein, J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

ATP; cortical neurons; FGF2; neuroprotection

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; APYRASE; FIBROBLAST GROWTH FACTOR 2;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL PROTECTION; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; INCUBATION TIME; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; RAT;

ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA; EMBRYO, MAMMALIAN; FIBROBLAST GROWTH FACTOR 2; HYDROLYSIS; NEURONS; PROTEIN BINDING; RATS; RATS, WISTAR; STAUROSPORINE;

EID: 70449529645     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.09.055     Document Type: Article

References (17)

1. Bikfalvi A., Klein S., Pintucci G., and Rifkin D.B. Biological roles of fibroblast growth factor-2. Endocr Rev 18 (1997) 26-45
2. Culmsee C., Stumm R.K., Schäfer M.K., Weihe E., and Krieglstein J. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. Eur J Pharmacol 379 (1999) 33-45
3. Gordon J.L. Extracellular ATP: effects, sources and fate. Biochem J 233 (1986) 309-319
4. Jin K., LaFevre-Bernt M., Sun Y., Chen S., Gafni J., Crippen D., Logvinova A., Ross C.A., Greenberg D.A., and Ellerby L.M. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A 102 (2005) 18189-18194
5. Klumpp S., Kriha D., Bechmann G., Maassen A., Maier S., Pallast S., Hoell P., and Krieglstein J. Phosphorylation of the growth factors bFGF, NGF and BDNF: a prerequisite for their biological activity. Neurochem Int 48 (2006) 131-137
6. König S., Hasche A., Pallast S., Krieglstein J., and Klumpp S. Detection of ATP-binding to growth factors. J Am Soc Mass Spectrom 19 (2008) 91-95
7. Lasker M., Bui C.D., Besant P.G., Sugawara K., Thai P., Medzihradszky G., and Turck C.W. Protein histidine phosphorylation: increased stability of thiophosphohistidine. Protein Sci 8 (1999) 2177-2185
8. Lenhard T., Schober A., Suter-Crazzolara C., and Unsicker K. Fibroblast growth factor-2 requires glial-cell-line-derived neurotrophic factor for exerting its neuroprotective actions on glutamate-lesioned hippocampal neurons. Mol Cell Neurosci 20 (2002) 181-197
9. Marques S.M., and da Silva J.C. An optimized luciferase bioluminescent assay for coenzyme A. Anal Bioanal Chem 391 (2008) 2161-2168
10. McElroy W.D. Properties of the reaction utilizing adenosinetriphosphate for bioluminescence. J Biol Cem 2 (1951) 547-557
11. Ornitz D.M., and Itoh N. Fibroblast growth factors. Genome Biol 2 (2001) 1-11
12. Richardson T.P., Trinkaus-Randall V., and Nugent M.A. Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate. J Biol Chem 274 (1999) 13534-13540
13. Rose K., Kriha D., Pallast S., Junker V., Klumpp S., and Krieglstein J. Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. Neurochem Int 51 (2007) 25-31
14. Rose K., Pallast S., Klumpp S., and Krieglstein J. ATP-binding on fibroblast growth factor 2 partially overlaps with the heparin-binding domain. J Biochem 144 (2008) 343-347
15. Thompson L.D., Pantoliano M.W., and Springer B.A. Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain. Biochemistry 33 (1994) 3831-3840
16. Traut T.W. Physiological concentrations of purines and pyrimidines. Mol Cell Biochem 140 (1994) 1-22
17. Wada K., Sugimori H., Bhide P.G., Moskowitz M.A., and Finklestein S.P. Effect of basic fibroblast growth factor treatment on brain progenitor cells after permanent focal ischemia in rats. Stroke 34 (2003) 2722-2728