Synthesis and biological evaluation of 99mTc-DMP-NGA as a novel hepatic asialoglycoprotein receptor imaging agent

Applied Radiation and Isotopes

Volumn 68, Issue 1, 2010, Pages 105-109

  Yang, Wenjiang ^a   Mou, Tiantian ^a   Zhang, Xianzhong ^a   Wang, Xuebin ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

99mTc; Asialoglycoprotein receptor; DMP NGA; Hepatic; Imaging agent

Indexed keywords

99MTC; ASIALOGLYCOPROTEIN RECEPTOR; DMP-NGA; HEPATIC; IMAGING AGENT;

COUPLING AGENTS; LIVER; OPTOELECTRONIC DEVICES;

TECHNETIUM;

ASIALOGLYCOPROTEIN RECEPTOR; GALACTOSYLNEOGLYCOALBUMIN TC 99M; HUMAN SERUM ALBUMIN; N SUCCINIMIDYL 2,3 DI (ACETYLTHIO)PROPIONATE; PROPIONIC ACID DERIVATIVE; TECHNETIUM 99M; TECHNETIUM DIETHYLENETRIAMINEPENTAACETIC ACID GALACTOSYL HUMAN SERUM ALBUMIN TC 99M; TECHNETIUM DIMERCAPTOPROPIONYL TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG PURIFICATION; DRUG PURITY; DRUG RECEPTOR BINDING; DRUG RETENTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE ANALYSIS; IN VIVO STUDY; ISOTOPE LABELING; LIVER FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOCHEMISTRY; STRUCTURE ANALYSIS;

ALBUMINS; ANIMALS; ASIALOGLYCOPROTEIN RECEPTOR; LIVER; MICE; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 70449529405     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2009.09.015     Document Type: Article

References (13)

1. DuBois M., Gilles K.A., Hamilton J.K., et al. Colorimetric method for determination of sugars and related substances. Anal Chem 28 (1956) 350-356
2. 99mTc-neolactosylated human serum albumin for imaging the hepatic asialoglycoprotein receptor. Bioconjug. Chem. 15 (2004) 850-855
3. Kokudo N., Vera D.R., and Makuuchi M. Clinical application of TcGSA. Nucl. Med. Biol. 30 (2003) 845-849
4. Kubota Y., Kojima M., Hazama H., et al. A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane: I. Evaluation of liver imaging using Tc-99m-neoglycoprotein. Jpn. J. Nucl. Med. 23 (1986) 899-905
5. m-GSA and its instant lyophilized kit for hepatic receptor imaging. J. Isot. 21 (2008) 88-94
6. 99mTc-labeled polypeptides with low in vivo protein binding. Nucl. Med. Biol. 28 (2001) 215-224
7. 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes. Bioconjug. Chem. 13 (2002) 491-501
8. Ono M., Arano Y., Uehara T., et al. Intracellular metabolic fate of radioactivity after injection of technetium-99m-labeled hydrazino nicotinamide derivatized proteins. Bioconjug. Chem. 10 (1999) 386-394
9. 99mTc-NGA as a clinically useful receptor-binding radiopharmaceutical. Nucl. Med. Biol. 28 (2001) 499-503
10. 99mTc-GSA, a new agent for functional imaging of the liver. Jpn. J. Nucl. Med. 28 (1991) 1321-1331
11. Vera D.R., Stadalnik R.C., and Krohn K.A. Technetium-99m galactosyl-neoglycoalbumin: preparation and preclinical studies. J. Nucl. Med. 26 (1985) 1157-1167
12. 99mTc-DMP-HSA, a new tracer agent for radionuclide ventriculography. Nucl. Med. Biol. 24 (1997) 571-578
13. Verbeke K.A., Vanbilloen H.P., De Roo M.J., et al. Technetium-99m mercaptoalbumin as a potential substitute or technetium-99m labelled red blood cells. Eur. J. Nucl. Med. 20 (1993) 473-482