Have some beneficial effects of hydroxychloroquine been overestimated? Potential biases in observational studies of drug effects: Comment on the article by Pons-Estel et al

Arthritis Care and Research

Volumn 61, Issue 11, 2009, Pages 1614-1615

  Vinet, Evelyne ^a   Bernatsky, Sasha ^a   Suissa, Samy ^b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; HYDROXYCHLOROQUINE;

DRUG EFFECT; DRUG EXPOSURE; HAZARD RATIO; HUMAN; KIDNEY INJURY; LETTER; LUPUS ERYTHEMATOSUS NEPHRITIS; OBSERVATIONAL STUDY; OBSERVER BIAS; PROPORTIONAL HAZARDS MODEL; RENAL PROTECTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

BIAS (EPIDEMIOLOGY); ENZYME INHIBITORS; HUMANS; HYDROXYCHLOROQUINE; KIDNEY; LUPUS NEPHRITIS; PROPORTIONAL HAZARDS MODELS;

EID: 70449513690     PISSN: 21514658     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.24895     Document Type: Letter

References (5)

1. Ruiz-Irastorza G, Egurbide M, Pijoan J, Garmendia M, Villar I, Martinez-Berriotxoa A, et al. Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus. Lupus 2006;15:577-583 (Pubitemid 44661744)
2. Pons-Estel GJ, Alarcon GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, et al. Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum 2009;61:830-839
3. Suissa S. Immortal time bias in pharmaco-epidemiology. Am J Epidemiol 2008;167:492-499
4. Suissa S. Immortal time bias in observational studies of drug effects. Pharmacoepidemiol Drug Saf 2007;16:241-249 (Pubitemid 46431687)
5. Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC. Treatment for lupus nephritis. Cochrane Database Syst Rev 2004;1:CD002922.