-
1
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28:360-369
-
(2008)
Semin Liver Dis
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
2
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 1994;76:1025-1037
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
-
3
-
-
0028609209
-
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
-
Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, et al. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994;8:2996-3007.
-
(1994)
Genes Dev
, vol.8
, pp. 2996-3007
-
-
Kallunki, T.1
Su, B.2
Tsigelny, I.3
Sluss, H.K.4
Derijard, B.5
Moore, G.6
-
5
-
-
0008290616
-
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
-
Leppa S, Bohmann D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene. 1999;18:6158-6162
-
(1999)
Oncogene
, vol.18
, pp. 6158-6162
-
-
Leppa, S.1
Bohmann, D.2
-
6
-
-
33745758229
-
C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
-
Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006;131:165-178
-
(2006)
Gastroenterology
, vol.131
, pp. 165-178
-
-
Gunawan, B.K.1
Liu, Z.X.2
Han, D.3
Hanawa, N.4
Gaarde, W.A.5
Kaplowitz, N.6
-
7
-
-
33744948514
-
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
-
Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem. 2006;281:12093-12101
-
(2006)
J Biol Chem
, vol.281
, pp. 12093-12101
-
-
Malhi, H.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
8
-
-
33746032571
-
Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
-
Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006;103:10544-10551
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10544-10551
-
-
Sakurai, T.1
Maeda, S.2
Chang, L.3
Karin, M.4
-
9
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420:333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
-
10
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad SciUS A. 2001;98:13681-13686
-
(2001)
Proc Natl Acad SciUS A
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
-
11
-
-
33746299139
-
High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
-
Zou Y, Li J, Lu C, Wang J, Ge J, Huang Y, et al. High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. Life Sci. 2006;79:1100-1107
-
(2006)
Life Sci
, vol.79
, pp. 1100-1107
-
-
Zou, Y.1
Li, J.2
Lu, C.3
Wang, J.4
Ge, J.5
Huang, Y.6
-
12
-
-
0030907282
-
A new model of acute liver steatosis induced in rats by fasting followed by refeeding a high carbohydrate-fat free diet. Biochemical and morphological analysis
-
Delzenne NM, Hernaux NA, Taper HS. A new model of acute liver steatosis induced in rats by fasting followed by refeeding a high carbohydrate-fat free diet. Biochemical and morphological analysis. J Hepatol. 1997;26:880-885
-
(1997)
J Hepatol
, vol.26
, pp. 880-885
-
-
Delzenne, N.M.1
Hernaux, N.A.2
Taper, H.S.3
-
13
-
-
0025374590
-
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells
-
D'Ambra R, Surana M, Efrat S, Starr RG, Fleischer N. Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology. 1990;126:2815-2822
-
(1990)
Endocrinology
, vol.126
, pp. 2815-2822
-
-
D'Ambra, R.1
Surana, M.2
Efrat, S.3
Starr, R.G.4
Fleischer, N.5
-
14
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
15
-
-
58949093454
-
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
-
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. 2009;49:87-96.
-
(2009)
Hepatology
, vol.49
, pp. 87-96
-
-
Singh, R.1
Wang, Y.2
Xiang, Y.3
Tanaka, K.E.4
Gaarde, W.A.5
Czaja, M.J.6
-
16
-
-
34250709565
-
Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125
-
Williams AS, Issa R, Leung SY, Nath P, Ferguson GD, Bennett BL, et al. Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther. 2007;322:351-359
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 351-359
-
-
Williams, A.S.1
Issa, R.2
Leung, S.Y.3
Nath, P.4
Ferguson, G.D.5
Bennett, B.L.6
-
17
-
-
52149106708
-
A peptide inhibitor of C-Jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
-
Lehnert M, Relja B, Sun-Young Lee V, Schwestka B, Henrich D, Czerny C, et al. A peptide inhibitor of C-Jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Shock. 2008;30:159-165
-
(2008)
Shock
, vol.30
, pp. 159-165
-
-
Lehnert, M.1
Relja, B.2
Sun-Young Lee, V.3
Schwestka, B.4
Henrich, D.5
Czerny, C.6
-
18
-
-
48649104386
-
Mitochondrial permeability transition in liver ischemia and reperfusion: Role of c-Jun N-terminal kinase 2
-
Theruvath TP, Snoddy MC, Zhong Z, Lemasters JJ. Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation. 2008;85:1500-1504
-
(2008)
Transplantation
, vol.85
, pp. 1500-1504
-
-
Theruvath, T.P.1
Snoddy, M.C.2
Zhong, Z.3
Lemasters, J.J.4
-
19
-
-
35948979743
-
Cell signaling in oxidative stress-induced liver injury
-
Czaja MJ. Cell signaling in oxidative stress-induced liver injury. Semin Liver Dis. 2007;27:378-389
-
(2007)
Semin Liver Dis
, vol.27
, pp. 378-389
-
-
Czaja, M.J.1
-
20
-
-
33847750361
-
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
-
Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA. Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology. 2007;45:412-421
-
(2007)
Hepatology
, vol.45
, pp. 412-421
-
-
Latchoumycandane, C.1
Goh, C.W.2
Ong, M.M.3
Boelsterli, U.A.4
-
21
-
-
0033966768
-
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
-
Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest. 2000;105:199-205.
-
(2000)
J Clin Invest
, vol.105
, pp. 199-205
-
-
Kido, Y.1
Burks, D.J.2
Withers, D.3
Bruning, J.C.4
Kahn, C.R.5
White, M.F.6
-
22
-
-
0031845136
-
Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription
-
Sul HS, Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr. 1998;18:331-351
-
(1998)
Annu Rev Nutr
, vol.18
, pp. 331-351
-
-
Sul, H.S.1
Wang, D.2
-
23
-
-
34247623638
-
Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1
-
Lu S, Archer MC. Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1. Exp Biol Med (Maywood). 2007;232:643-653
-
(2007)
Exp Biol Med (Maywood)
, vol.232
, pp. 643-653
-
-
Lu, S.1
Archer, M.C.2
-
24
-
-
0029829455
-
Increased hepatocyte CYP2E1expression ina ratnutritionalmodel ofhepatic steatosis with inflammation
-
Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1expression ina ratnutritionalmodel ofhepatic steatosis with inflammation. Gastroenterology. 1996;111:1645-1653
-
(1996)
Gastroenterology
, vol.111
, pp. 1645-1653
-
-
Weltman, M.D.1
Farrell, G.C.2
Liddle, C.3
-
25
-
-
33845791439
-
Reactive oxygen species in in vitro pesticideinduced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFkappaB and caspase-3
-
Jia Z, Misra HP. Reactive oxygen species in in vitro pesticideinduced neuronal cell (SH-SY5Y) cytotoxicity: role of NFkappaB and caspase-3. Free Radic Biol Med. 2007;42:288-298
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 288-298
-
-
Jia, Z.1
Misra, H.P.2
-
26
-
-
47349101596
-
Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR
-
Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, et al. Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR. Apoptosis. 2008;13:1031-1042
-
(2008)
Apoptosis
, vol.13
, pp. 1031-1042
-
-
Wei, Y.1
Weng, D.2
Li, F.3
Zou, X.4
Young, D.O.5
Ji, J.6
-
27
-
-
28444443379
-
4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: The role of PKC-delta
-
Castello L, Marengo B, Nitti M, Froio T, Domenicotti C, Biasi F, et al. 4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: the role of PKC-delta. Biochim Biophys Acta. 2005;1737:83-93.
-
(2005)
Biochim Biophys Acta
, vol.1737
, pp. 83-93
-
-
Castello, L.1
Marengo, B.2
Nitti, M.3
Froio, T.4
Domenicotti, C.5
Biasi, F.6
-
28
-
-
0036894360
-
Interleukin-6 induces cellular insulin resistance in hepatocytes
-
Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 2002;51:3391-3399
-
(2002)
Diabetes
, vol.51
, pp. 3391-3399
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
Mooney, R.A.4
-
29
-
-
0035183475
-
Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
-
Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 2001;34:1158-1163
-
(2001)
Hepatology
, vol.34
, pp. 1158-1163
-
-
Crespo, J.1
Cayon, A.2
Fernandez-Gil, P.3
Hernandez-Guerra, M.4
Mayorga, M.5
Dominguez-Diez, A.6
-
30
-
-
34250632770
-
Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
-
Manco M, Marcellini M, Giannone G, Nobili V. Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol. 2007;127:954-960
-
(2007)
Am J Clin Pathol
, vol.127
, pp. 954-960
-
-
Manco, M.1
Marcellini, M.2
Giannone, G.3
Nobili, V.4
-
31
-
-
33645828828
-
The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
-
Assi K, Pillai R, Gomez-Munoz A, Owen D, Salh B. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology. 2006;118:112-121
-
(2006)
Immunology
, vol.118
, pp. 112-121
-
-
Assi, K.1
Pillai, R.2
Gomez-Munoz, A.3
Owen, D.4
Salh, B.5
-
32
-
-
33646161443
-
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
-
Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, Goverud I, et al. Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol. 2006;44:1167-1174
-
(2006)
J Hepatol
, vol.44
, pp. 1167-1174
-
-
Haukeland, J.W.1
Damas, J.K.2
Konopski, Z.3
Loberg, E.M.4
Haaland, T.5
Goverud, I.6
-
33
-
-
44949233003
-
Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
-
Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol. 2008;103:1372-1379
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 1372-1379
-
-
Wieckowska, A.1
Papouchado, B.G.2
Li, Z.3
Lopez, R.4
Zein, N.N.5
Feldstein, A.E.6
-
34
-
-
33645218763
-
Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair
-
Jin X, Zimmers TA, Perez EA, Pierce RH, Zhang Z, Koniaris LG. Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair. Hepatology. 2006;43:474-484 1362
-
(2006)
Hepatology
, vol.43
, pp. 474-484
-
-
Jin, X.1
Zimmers, T.A.2
Perez, E.A.3
Pierce, R.H.4
Zhang, Z.5
Koniaris, L.G.6
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