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Volumn 44, Issue 11, 2009, Pages 1356-1362

Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis

Author keywords

C Jun N terminal kinase; Inflammation; Insulin resistance; Non alcoholic steatohepatitis; Oxidative stress; SP600125

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; DIMETHYL SULFOXIDE; FATTY ACID; GLUCOSE; INSULIN; INTERLEUKIN 6; MALONALDEHYDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 70449512879     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365520903312441     Document Type: Article
Times cited : (8)

References (34)
  • 1
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28:360-369
    • (2008) Semin Liver Dis , vol.28 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 2
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 1994;76:1025-1037
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6
  • 3
    • 0028609209 scopus 로고
    • JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
    • Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, et al. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 1994;8:2996-3007.
    • (1994) Genes Dev , vol.8 , pp. 2996-3007
    • Kallunki, T.1    Su, B.2    Tsigelny, I.3    Sluss, H.K.4    Derijard, B.5    Moore, G.6
  • 4
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol. 2007;19:142-149
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 5
    • 0008290616 scopus 로고    scopus 로고
    • Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
    • Leppa S, Bohmann D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene. 1999;18:6158-6162
    • (1999) Oncogene , vol.18 , pp. 6158-6162
    • Leppa, S.1    Bohmann, D.2
  • 7
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem. 2006;281:12093-12101
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 8
    • 33746032571 scopus 로고    scopus 로고
    • Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    • Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006;103:10544-10551
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10544-10551
    • Sakurai, T.1    Maeda, S.2    Chang, L.3    Karin, M.4
  • 11
    • 33746299139 scopus 로고    scopus 로고
    • High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    • Zou Y, Li J, Lu C, Wang J, Ge J, Huang Y, et al. High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. Life Sci. 2006;79:1100-1107
    • (2006) Life Sci , vol.79 , pp. 1100-1107
    • Zou, Y.1    Li, J.2    Lu, C.3    Wang, J.4    Ge, J.5    Huang, Y.6
  • 12
    • 0030907282 scopus 로고    scopus 로고
    • A new model of acute liver steatosis induced in rats by fasting followed by refeeding a high carbohydrate-fat free diet. Biochemical and morphological analysis
    • Delzenne NM, Hernaux NA, Taper HS. A new model of acute liver steatosis induced in rats by fasting followed by refeeding a high carbohydrate-fat free diet. Biochemical and morphological analysis. J Hepatol. 1997;26:880-885
    • (1997) J Hepatol , vol.26 , pp. 880-885
    • Delzenne, N.M.1    Hernaux, N.A.2    Taper, H.S.3
  • 13
    • 0025374590 scopus 로고
    • Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells
    • D'Ambra R, Surana M, Efrat S, Starr RG, Fleischer N. Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology. 1990;126:2815-2822
    • (1990) Endocrinology , vol.126 , pp. 2815-2822
    • D'Ambra, R.1    Surana, M.2    Efrat, S.3    Starr, R.G.4    Fleischer, N.5
  • 14
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 15
    • 58949093454 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    • Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. 2009;49:87-96.
    • (2009) Hepatology , vol.49 , pp. 87-96
    • Singh, R.1    Wang, Y.2    Xiang, Y.3    Tanaka, K.E.4    Gaarde, W.A.5    Czaja, M.J.6
  • 16
    • 34250709565 scopus 로고    scopus 로고
    • Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125
    • Williams AS, Issa R, Leung SY, Nath P, Ferguson GD, Bennett BL, et al. Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther. 2007;322:351-359
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 351-359
    • Williams, A.S.1    Issa, R.2    Leung, S.Y.3    Nath, P.4    Ferguson, G.D.5    Bennett, B.L.6
  • 17
    • 52149106708 scopus 로고    scopus 로고
    • A peptide inhibitor of C-Jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    • Lehnert M, Relja B, Sun-Young Lee V, Schwestka B, Henrich D, Czerny C, et al. A peptide inhibitor of C-Jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Shock. 2008;30:159-165
    • (2008) Shock , vol.30 , pp. 159-165
    • Lehnert, M.1    Relja, B.2    Sun-Young Lee, V.3    Schwestka, B.4    Henrich, D.5    Czerny, C.6
  • 18
    • 48649104386 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in liver ischemia and reperfusion: Role of c-Jun N-terminal kinase 2
    • Theruvath TP, Snoddy MC, Zhong Z, Lemasters JJ. Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation. 2008;85:1500-1504
    • (2008) Transplantation , vol.85 , pp. 1500-1504
    • Theruvath, T.P.1    Snoddy, M.C.2    Zhong, Z.3    Lemasters, J.J.4
  • 19
    • 35948979743 scopus 로고    scopus 로고
    • Cell signaling in oxidative stress-induced liver injury
    • Czaja MJ. Cell signaling in oxidative stress-induced liver injury. Semin Liver Dis. 2007;27:378-389
    • (2007) Semin Liver Dis , vol.27 , pp. 378-389
    • Czaja, M.J.1
  • 20
    • 33847750361 scopus 로고    scopus 로고
    • Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
    • Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA. Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology. 2007;45:412-421
    • (2007) Hepatology , vol.45 , pp. 412-421
    • Latchoumycandane, C.1    Goh, C.W.2    Ong, M.M.3    Boelsterli, U.A.4
  • 21
    • 0033966768 scopus 로고    scopus 로고
    • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    • Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest. 2000;105:199-205.
    • (2000) J Clin Invest , vol.105 , pp. 199-205
    • Kido, Y.1    Burks, D.J.2    Withers, D.3    Bruning, J.C.4    Kahn, C.R.5    White, M.F.6
  • 22
    • 0031845136 scopus 로고    scopus 로고
    • Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription
    • Sul HS, Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr. 1998;18:331-351
    • (1998) Annu Rev Nutr , vol.18 , pp. 331-351
    • Sul, H.S.1    Wang, D.2
  • 23
    • 34247623638 scopus 로고    scopus 로고
    • Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1
    • Lu S, Archer MC. Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1. Exp Biol Med (Maywood). 2007;232:643-653
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 643-653
    • Lu, S.1    Archer, M.C.2
  • 24
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1expression ina ratnutritionalmodel ofhepatic steatosis with inflammation
    • Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1expression ina ratnutritionalmodel ofhepatic steatosis with inflammation. Gastroenterology. 1996;111:1645-1653
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 25
    • 33845791439 scopus 로고    scopus 로고
    • Reactive oxygen species in in vitro pesticideinduced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFkappaB and caspase-3
    • Jia Z, Misra HP. Reactive oxygen species in in vitro pesticideinduced neuronal cell (SH-SY5Y) cytotoxicity: role of NFkappaB and caspase-3. Free Radic Biol Med. 2007;42:288-298
    • (2007) Free Radic Biol Med , vol.42 , pp. 288-298
    • Jia, Z.1    Misra, H.P.2
  • 26
    • 47349101596 scopus 로고    scopus 로고
    • Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR
    • Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, et al. Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR. Apoptosis. 2008;13:1031-1042
    • (2008) Apoptosis , vol.13 , pp. 1031-1042
    • Wei, Y.1    Weng, D.2    Li, F.3    Zou, X.4    Young, D.O.5    Ji, J.6
  • 27
    • 28444443379 scopus 로고    scopus 로고
    • 4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: The role of PKC-delta
    • Castello L, Marengo B, Nitti M, Froio T, Domenicotti C, Biasi F, et al. 4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: the role of PKC-delta. Biochim Biophys Acta. 2005;1737:83-93.
    • (2005) Biochim Biophys Acta , vol.1737 , pp. 83-93
    • Castello, L.1    Marengo, B.2    Nitti, M.3    Froio, T.4    Domenicotti, C.5    Biasi, F.6
  • 28
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 2002;51:3391-3399
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 29
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 2001;34:1158-1163
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3    Hernandez-Guerra, M.4    Mayorga, M.5    Dominguez-Diez, A.6
  • 30
    • 34250632770 scopus 로고    scopus 로고
    • Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
    • Manco M, Marcellini M, Giannone G, Nobili V. Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol. 2007;127:954-960
    • (2007) Am J Clin Pathol , vol.127 , pp. 954-960
    • Manco, M.1    Marcellini, M.2    Giannone, G.3    Nobili, V.4
  • 31
    • 33645828828 scopus 로고    scopus 로고
    • The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    • Assi K, Pillai R, Gomez-Munoz A, Owen D, Salh B. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology. 2006;118:112-121
    • (2006) Immunology , vol.118 , pp. 112-121
    • Assi, K.1    Pillai, R.2    Gomez-Munoz, A.3    Owen, D.4    Salh, B.5
  • 32
    • 33646161443 scopus 로고    scopus 로고
    • Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
    • Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, Goverud I, et al. Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol. 2006;44:1167-1174
    • (2006) J Hepatol , vol.44 , pp. 1167-1174
    • Haukeland, J.W.1    Damas, J.K.2    Konopski, Z.3    Loberg, E.M.4    Haaland, T.5    Goverud, I.6
  • 34
    • 33645218763 scopus 로고    scopus 로고
    • Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair
    • Jin X, Zimmers TA, Perez EA, Pierce RH, Zhang Z, Koniaris LG. Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair. Hepatology. 2006;43:474-484 1362
    • (2006) Hepatology , vol.43 , pp. 474-484
    • Jin, X.1    Zimmers, T.A.2    Perez, E.A.3    Pierce, R.H.4    Zhang, Z.5    Koniaris, L.G.6


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