FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia

European Journal of Haematology

Volumn 83, Issue 6, 2009, Pages 541-549

  Nückel, Holger ^a,b   Collins, Crista H ^b   Frey, Ulrich H ^b,c   Sellmann, Ludger ^a   Dürig, Jan ^a   Siffert, Winfried ^b   Dührsen, Ulrich ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b Institute of Pharmacogenetics   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

B cell chronic lymphocytic leukemia; Fc receptor like 2; Immunoglobulin heavy chain; Prognostic marker; SNP

Indexed keywords

CD38 ANTIGEN; FC RECEPTOR; FC RECEPTOR LIKE 2; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA; PROTEIN KINASE ZAP 70; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER GROWTH; CANCER RISK; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOGENETICS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GENOMICS; HUMAN; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UNIVARIATE ANALYSIS;

AGED; ANTIGENS, CD38; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HEMATOLOGIC DISEASES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECEPTORS, CELL SURFACE; RETROSPECTIVE STUDIES; RNA, MESSENGER; RNA, NEOPLASM; ROC CURVE; SURVIVAL ANALYSIS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 70449493088     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01328.x     Document Type: Article

References (28)

1. Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1975 46 : 219 234.
2. Binet JL, Lepoprier M, Dighiero G, et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 1977 40 : 855 864.
3. Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 1999 17 : 399 408.
4. Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002 100 : 1410 1416.
5. Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000 343 : 1910 1916. (Pubitemid 32064784)
6. Zenz T, Krober A, Scherer K, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 2008 112 : 3322 3329.
7. Hamblin TJ, Orchard JA, Ibbotson RE, et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 2002 99 : 1023 1029.
8. Ibrahim S, Keating M, Do KA, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001 98 : 181 186.
9. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003 348 : 1764 1775. (Pubitemid 36514707)
10. Dürig J, Nückel H, Cremer M, et al. ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia. Leukemia 2003 17 : 2426 2434.
11. Haslinger C, Schweifer N, Stilgenbauer S, et al. Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status. J Clin Oncol 2004 22 : 3937 3949.
12. Dürig J, Nückel H, Hüttmann A, et al. Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. Blood 2003 101 : 2748 2755.
13. Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001 194 : 1639 1647.
14. Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004 351 : 893 901.
15. Heintel D, Kienle D, Shehata M, et al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. Leukemia 2005 19 : 1216 1223.
16. Nückel H, Hüttmann A, Klein-Hitpass L, et al. Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia. Leuk Lymphoma 2006 47 : 1053 1061.
17. Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003 101 : 4944 4951.
18. Hüttmann A, Klein-Hitpass L, Thomale J, et al. Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia 2006 20 : 1774 1782.
19. Davis RS. Fc receptor-like molecules. Annu Rev Immunol 2007 25 : 525 560.
20. Li FJ, Ding S, Pan J, et al. FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia. Blood 2008 112 : 179 187.
21. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008 111 : 5446 5456.
22. Dürig J, Naschar M, Schmucker U, et al. CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia. Leukemia 2002 16 : 30 5.
23. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002 3 : RESEARCH0034.
24. Schroers R, Griesinger F, Trumper L, et al. Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Leukemia 2005 19 : 750 758.
25. Nieto A, Caliz R, Pascual M, et al. Involvement of Fcgamma receptor IIIA genotypes in susceptibility to rheumatoid arthritis. Arthritis Rheum 2000 43 : 735 739.
26. Kimberly RP, Wu J, Gibson AW, et al. Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity. Immunol Res 2002 26 : 177 189.
27. Marrack P, Kappler J, Kotzin BL. Autoimmune disease: why and where it occurs. Nat Med 2001 7 : 899 905.
28. Tsao BP. The genetics of human systemic lupus erythematosus. Trends Immunol 2003 24 : 595 602.