Phenytoin toxicity and thyroid dysfunction

New Zealand Medical Journal

Volumn 122, Issue 1303, 2009, Pages 102-104

  Betteridge, Tobias ^a   Fink, John ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; PHENYTOIN; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; ATAXIA; CASE REPORT; CLINICAL EXAMINATION; COORDINATION DISORDER; DIPLOPIA; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG INTOXICATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSARTHRIA; EPILEPSY; EUTHYROIDISM; FALLING; FEMALE; FREE THYROXINE INDEX; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; NEUROLOGIC EXAMINATION; NYSTAGMUS; PATIENT COMPLIANCE; SIDE EFFECT; SPEECH DISORDER; TENDON REFLEX; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; VISUAL DISORDER;

ANTICONVULSANTS; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOTHYROIDISM; MIDDLE AGED; PHENYTOIN; THYROXINE;

EID: 70449491017     PISSN: None     EISSN: 11758716     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Aanderud S. Strandjord RE. Hypothyroidism induced by anti-epileptic therapy. Acta Neurol Scand. 1980;61(5):330-332
2. Sarich TC, Wright JM. Hypothyroxinaemia and phenytoin toxicity: a vicous circle. Drug Metabol Drug Interact. 1996;13(2):155-160
3. Horii K, Fujitake J, Tatsuoka Y, et al. A case of phenytoin intoxication induced by hypothyroidism. Rinsho Shinkeigaku. 1991;31(5):528-533
4. Kushnir M, Weinstein R, Baruch M, Gadoth N. Hypothyroidism and phenytoin intoxication. Ann Intern Med. 1985;102(3):341-342
5. Blackshear JL, Schultz AL, Napier JS, Stuart DD. Thyroxine replacement requirements in hypothyroid patients receiving phenytoin. Ann Intern Med. 1983;99(3):341-342
6. Fichsel H. Hormonelle veranderungen unter antikonvulsiva. Epilepsie. 1984;82:119-128
7. Oppenheimer JH, Fisher LV, Nelson KM, Jailer JW. Depression of the serum protein-bound iodine level by diphenylhydantoin. J Clin Endocrinol Metab. 1961;21:252-262
8. Larsen PR, Atkinson AJ Jr, Wellman JN, Goldsmith RE. The effect of diphenylhydantoin on thyroxine metabolism in man. J Clin Invest. 1970;49:1266-1279
9. Liewendahl K, Majuri H, Helenius T. Thyroid function tests in patients on long-term treatment with various anticonvulsant drugs. Clinical Endocrinol. 1978;8:185-191 (Pubitemid 8287886)
10. Finucane JF, Griffiths RS. Effect of phenytoin therapy on thyroid function. Br J Clin Pharmacol. 1976;3:1041-1044