Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia

Journal of Psychopharmacology

Volumn 23, Issue 8, 2009, Pages 937-943

  Liu, Y C ^a   Huang, C L ^b   Wu, P L ^b   Chang, Y C ^c   Huang, C H ^b   Lane, H Y ^b  

^a Shinyin Hospital   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAMKANG UNIVERSITY   (Taiwan)

Author keywords

AKT; Antipsychotics; Negative symptoms; Positive symptoms; Social function

Indexed keywords

PROTEIN KINASE B; RISPERIDONE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; DISEASE EXACERBATION; FEMALE; FUNCTIONAL ASSESSMENT; GENETIC SUSCEPTIBILITY; GENOTYPE; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RESEARCH; MENTAL DISEASE; MENTAL PATIENT; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL STATUS; SYMPTOM;

ADULT; FEMALE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-AKT; RISPERIDONE; SCHIZOPHRENIA; SOCIAL BEHAVIOR;

EID: 70449389118     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108093840     Document Type: Article

References (41)

1. American Psychiatric Association (1995) Structured Clinical Interview for DSM-IV. Washington, DC: American Psychiatric Press.
2. Andreasen, NC, Flaum, M., Swayze, VW, Tyrrell, G., Arndt, S. (1990) Positive and negative symptoms in schizophrenia. A critical reappraisal. Arch Gen Psychiatry 47: 615-621.
3. Bajestan, SN, Sabouri, AH, Nakamura, M., Takashima, H., Keikhaee, MR, Behdani, F., et al. (2006) Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. Am J Med Genet B Neuropsychiatr Genet 141: 383-386.
4. Beaulieu, JM, Sotnikova, TD, Yao, WD, Kockeritz, L., Woodgett, JR, Gainetdinov, RR, et al. (2004) Lithium antagonizes dopaminedependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A 101: 5099-5104.
5. Chalecka-Franaszek, E., Chuang, DM (1999) Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci U S A 96: 8745-8750.
6. Chouinard, G., Ross-Chouinard, A., Annable, L., Jones, BD (1980) The extrapyramidal symptom rating scale. Can J Neurol Sci 7: 233.
7. Couture, SM, Penn, DL, Roberts, DL (2006) The functional significance of social cognition in schizophrenia: a review. Schizophr Bull 32 (Suppl. 1). S44 - S63.
8. Craddock, N., ODonovan, MC, Owen, MJ (2006) Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32: 9-16.
9. Emamian, ES, Hall, D., Birnbaum, MJ, Karayiorgou, M., Gogos, JA (2004) Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36: 131-137.
10. Franke, TF, Yang, SI, Chan, TO, Datta, K., Kazlauskas, A., Morrison, DK, et al. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736.
11. Green, MF, Barnes, TR, Danion, JM, Gallhofer, B., Meltzer, HY, Pantelis, C. (2005) The FOCIS international survey on psychiatrists opinions on cognition in schizophrenia. Schizophr Res 74: 253-261.
12. Harrison, PJ, Owen, MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361: 417-419.
13. Harrison, PJ, Weinberger, DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10: 40-68.
14. Honigfeld, G., Klett, CJ (1965) The Nurses Observation Scale for Inpatient Evaluation (NOSIE). a new scale for measuring improvement in chronic schizophrenia. J Clin Psychol 21: 65-71.
15. Ide, M., Ohnishi, T., Murayama, M., Matsumoto, I., Yamada, K., Iwayama, Y., et al. (2006) Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. J Neurochem 99: 277-287.
16. Ikeda, M., Iwata, N., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., et al. (2004) Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry 56: 698-700.
17. Kay, SR, Fiszbein, A., Opler, LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
18. Kane, J., Honigfeld, G., Singer, J., Meltzer, H. (1988) Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45: 789-796.
19. Lai, S., Xu, B., Westphal, KG, Paterlini, M., Olivier, B., Pavlidis, P., et al. (2006) AKT1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proc Natl Acad Sci U S A 103: 16906-16911.
20. Lane, HY, Chang, YC, Chiu, CC, Chen, ML, Hsieh, MH, Chang, WH (2002) Association of risperidone treatment response with a polymorphism in the 5-HT2A receptor gene. Am J Psychiatry 159: 1593-1595.
21. Lane, HY, Chiu, WC, Chou, JCY, Wu, ST, Su, MH, Chang, WH (2000) Risperidone in acutely exacerbated schizophrenia: dosing strategies and plasma levels. J Clin Psychiatry 61: 209-214.
22. Lane, HY, Lee, CC, Chang, YC, Lu, CT, Huang, CH, Chang, WH (2004) Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. Int J Neuropsychopharmacol 7: 461-470.
23. Lane, HY, Lee, CC, Liu, YC, Chang, WH (2005) Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics. Pharmacogenomics 6: 139-149.
24. Lencz, T., Robinson, DG, Xu, K., Ekholm, J., Sevy, S., Gunduz-Bruce, H., et al. (2006) DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Am J Psychiatry 163: 529-531.
25. Lingjaerde, O., Ahlfors, UG, Bech, P., Dencker, SJ, Elgen, K. (1987) The UKU side effect rating scale. A new comprehensive ration scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 334 (Suppl.). 1-100.
26. Liu, YL, Fann, CS, Liu, CM, Wu, JY, Hung, SI, Chan, HY, et al. (2006) Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population. Psychiatr Genet 16: 39-41.
27. Lung, FW, Tzeng, DS, Shu, BC (2002) Ethnic heterogeneity in allele variation in the DRD4 gene in schizophrenia. Schizophr Res 57: 239-245.
28. Mizuno, M., Yamada, K., Takei, N., Tran, MH, He, J., Nakajima, A., et al. (2003) Phosphatidylinositol 3-kinase: A molecule mediating BDNF-dependent spatialmemory formation. Mol Psychiatry 8: 217-224.
29. Norton, N., Williams, HJ, Dwyer, S., Carroll, L., Peirce, T., Moskvina, V., et al. (2007) Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophr Res 93: 58-65.
30. Ohtsuki, T., Inada, T., Arinami, T. (2004) Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population. Mol Psychiatry 9: 981-983.
31. Overall, JE, Gorham, DR (1962) The Brief Psychiatric Rating Scale. Psychol Rep 10: 799-812.
32. Pinheiro, AP, Keefe, RS, Skelly, T., Olarte, M., Leviel, K., Lange, LA, et al. (2007) AKT1 and neurocognition in schizophrenia. Aust N Z J Psychiatry 41: 169-177.
33. Sawa, A., Snyder, SH (2002) Schizophrenia: diverse approaches to a complex disease. Science 296: 692-695.
34. Schwab, SG, Hoefgen, B., Hanses, C., Hassenbach, MB, Albus, M., Lerer, B., et al. (2005) Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sibpair families. Biol Psychiatry 58: 446-450.
35. Staal, SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 84: 5034-5037.
36. Thiselton, DL, Vladimirov, VI, Kuo, PH, McClay, J., Wormley, B., Fanous, A. Oneill, FA, Walsh, D., Van den Oord, EJ, Kendler, KS, Riley, BP (2008) AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry 63: 449-457.
37. Turunen, JA, Peltonen, JO, Pietilainen, OP, Hennah, W., Loukola, A., Paunio, T., et al. (2007) The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res 91: 27-36.
38. Wang, Q., Liu, L., Pei, L., Ju, W., Ahmadian, G., Lu, J., et al. (2003) Control of synaptic strength, a novel function of Akt. Neuron 38: 915-928.
39. Winantea, J., Hoang, MN, Ohlraun, S., Rietschel, M., Cichon, S., Propping, P., et al. (2006) A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci. Eur J Hum Genet 14: 1037-1043.
40. Xu, MQ, Xing, QH, Zheng, YL, Li, S., Gao, JJ, He, G., et al. (2007) Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. J Clin Psychiatry 68: 1358-1367.
41. Ye, S., Dhillon, S., Ke, X., Collins, AR, Day, IN (2001) An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 29: E88 - E98.