Distribution of dipyridamole in blood components among post-stroke patients treated with extended release formulation

Thrombosis and Haemostasis

Volumn 102, Issue 3, 2009, Pages 538-543

  Serebruany, Victor ^a   Sabaeva, Elena ^a   Booze, Christopher ^a   Atar, Oliver D ^a   Eisert, Christian ^a   Hanley, Dan ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Dipyridamole; Erythrocytes; Leukocytes; Pharmacokinetics; Plasma; Platelets; Spectrofluorimetry; Stroke

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; ANTIHYPERTENSIVE AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPERGLYCEMIC AGENT;

ADULT; ARTICLE; BLOOD COMPONENT; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CELL ISOLATION; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG FATALITY; DRUG FORMULATION; DRUG INDUCED HEADACHE; ERYTHROCYTE; FEMALE; HUMAN; LEUKOCYTE; MALE; NAUSEA AND VOMITING; PRIORITY JOURNAL; SPECTROFLUOROMETRY; THROMBOCYTE; UNSPECIFIED SIDE EFFECT;

AGED; ASPIRIN; BLOOD PLATELETS; DELAYED-ACTION PREPARATIONS; DIPYRIDAMOLE; DRUG COMBINATIONS; ERYTHROCYTES; FEMALE; HUMANS; ISCHEMIA; LEUKOCYTES; MALE; MIDDLE AGED; RISK FACTORS; SPECTROMETRY, FLUORESCENCE; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 70449381345     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-03-0158     Document Type: Article

References (36)

1. Diener HC, Cunha L, Forbes C, et al. European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143: 1-13.
2. ESPRIT Study Group; Halkes PH, van Gijn J, Kappelle LJ, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 2006; 367: 1665-1673 .
3. Albers GW, Amarenco P, Easton JD, et. al. Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 483S-512S.
4. Sacco RL, Diener HC, Yusuf S, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med 2008; 359: 1238-1251.
5. Gresele P, Zoja C, Deckmyn H, et al. Dipyridamole inhibits platelet aggregation in whole blood. Thromb Haemost. 1983; 50: 852-856. (Pubitemid 14218224)
6. Akinboboye OO, Idris O, Chou RL, et al. Absolute quantitation of coronary steal induced by intravenous dipyridamole. J Am Coll Cardiol 2001; 37: 109-116. (Pubitemid 32051725)
7. Eisert WG. Near-field amplification of antithrombotic effects of dipyridamole through vessel wall cells. Neurology 2001; 57: S20-S23.
8. Iuliano L, Pedersen JZ, Rotilio G, et.al. A potent chain-breaking antioxidant activity of the cardiovascular drug dipyridamole. Free Radical Biol Med 1995; 18: 239-247.
9. Neri Serneri GG, Masotti G, Poggesi L, et al. Enhanced prostacyclin production by dipyridamole in man. Eur J Clin Pharmacol 1981; 21: 9-15. (Pubitemid 12237823)
10. Bult H, Fret HR, Jordaens FH, et al. Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide. Eur J Pharmacol 1991; 199: 1-8.
11. Singh JP, Rothfuss KJ, Wiernicki TR, et al. Dipyridamole directly inhibits vascular smooth muscle cell profileration in vitro and in vivo: implications in the treatment of restenosis after angioplasty. J Am Coll Cardiol 1994; 23: 665-671.
12. Ruggiero AC, Nepomuceno MF, Jacob RF, et al. Antioxidant effect of dipyridamole and its derivative RA 25 upon lipid peroxidation and hemolysis in red blood cells. 1: Physiol Chem Phys Med NMR 2000; 32: 35-48.
13. Pulgarin JAM, Alanon Molina A, Fernandez Lopez P. Direct determination of dipyridamole in serum. Anal Biochem 1997; 245: 8-16.
14. Serebruany V, Pokov I, Hanley D. Spectrofluorimetric assessment of plasma dipyridamole stability: Sample storage for multicenter clinical trials? Thromb Res 2008; 123: 184-186.
15. Gencheva E, Sloan M, Leurgans S, et al. Attrition and non-compliance in secondary stroke prevention trials. Neuroepidemiology 2004; 23: 61-66. (Pubitemid 38142274)
16. Serebruany VL, Hanley DF, Atar D, et al. Non-compliance in antiplatelet trials: The AGATE trial perspective. Stroke 2004; 35: 143.
17. Nagaeva O, Bondestam K, Olofsson J, et al. An optimized technique for separation of human decidual leukocytes for cellular and molecular analyses. Am J Reprod Immunol 2002; 47: 203-212. (Pubitemid 34436210)
18. Ford TC, Graham J, Rickwood D. A new, rapid, onestep method for the isolation of platelets from human blood Clin Chim Acta 1990; 192 : 115-120.
19. Oshrine BR, Malinin AI, Pokov AN, et al. Changes of pH are critical for accurate fluorometric measurements of dipyridamole levels in biological fluids. Meth Find Exp Clin Pharm 2005; 27: 95-100. (Pubitemid 40502783)
20. Mahony C, Cox JL, Bjornsson TD. Plasma dipyridamole concentrations after two different dosage regimens in patients. J Clin Pharmacol 1983; 23: 123-126.
21. Bjornsson TD, Mahony C. Clinical pharmacokinetics of dipyridamole. Thromb Res (Suppl) 1983; 4: 93-104.
22. Tyce GM, Fuster V, Owen CA Jr. Dipyridamole levels in plasma of man and other species. Res Commun Chem Pathol Pharmacol 1979; 26: 495-508. (Pubitemid 10164729)
23. Müller TH, Su CA, Weisenberger H, et al. Dipyridamole alone or combined with low-dose acetylsalicylic acid inhibits platelet aggregation in human whole blood ex vivo. Br J Clin Pharmacol 1990; 30: 179-186. (Pubitemid 20237889)
24. Casper ES, Baselga J, Smart TB, et al. A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma. Cancer Chemother Pharmacol 1991; 28: 51-54.
25. Serebruany VL, Malinin AI, Hanley DF. Magnitude and time course of platelet inhibition with extended release dipyridamole with or without aspirin in healthy Japanese volunteers. The AGgrenox versus Aspirin Therapy Evaluation (AGATE-Japan). Thromb Haemost 2008; 99: 116-120.
26. Stafford NP, Pink AE, White AE, et al. Mechanisms involved in adenosine triphosphate-induced platelet aggregation in whole blood. Arterioscler Thromb Vasc Biol 2003; 23: 1928-1933. (Pubitemid 37254886)
27. Besselink GA, van Engelenburg FA, Ebbing IG, et al. Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment. Vox Sang 2003; 85: 25-30.
28. Vargas F, Cheng AT, Velutini G, et al. In vitro antioxidant and photo-oxidant properties of dipyridamole. Int J Toxicol 2001; 20: 363-368.
29. Ruggiero AC, Nepomuceno MF, Jacob RF, et al. Antioxidant effect of dipyridamole (DIP) and its derivative RA 25 upon lipid peroxidation and hemolysis in red blood cells. Physiol Chem Phys Med NMR 2000; 32: 35-48.
30. Bozzo J, Hernández MR, Ordinas A. Reduced red cell deformability associated with blood flow and platelet activation: improved by dipyridamole alone or combined with aspirin. Cardiovasc Res 1995; 30: 725-730.
31. Coccia R, Spadaccio C, Foppoli C, et al. The effect of simvastatin on erythrocyte membrane fluidity during oxidative stress induced by cardiopulmonary bypass: a randomized controlled study. Clin Ther 2007; 29: 1706-1717. (Pubitemid 47494546)
32. Hallevi H, Hazan-Halevy I, Paran E. Modification of neutrophil adhesion to human endothelial cell line in acute ischemic stroke by dipyridamole and candesartan. Eur J Neurol 2007; 14: 1002-1007. (Pubitemid 47300773)
33. Al-Bahrani A, Taha S, Shaath H, et al. TNF-alpha and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents. Curr Neurovasc Res 2007; 4: 31-37. (Pubitemid 46280289)
34. Weyrich AS, Kraiss LW, Prescott SM, Zimmerman GA. New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates. Trends Cardiovasc Med 2006; 16: 75-80.
35. Kim HH, Liao JK. Translational therapeutics of dipyridamole. Arterioscler Thromb Vasc Biol 2008; 28: s39-42.
36. Aktas B, Utz A, Hoenig-Liedl P, et al. Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke 2003; 34: 764-769. (Pubitemid 36307408)