Myosin VI is a modulator of androgen-dependent gene expression

Oncology Reports

Volumn 22, Issue 5, 2009, Pages 991-995

  Loikkanen, Ildikó ^a   Toljamo, Katja ^a   Hirvikoski, Pasi ^b   Väisänen, Timo ^a,b   Paavonen, Timo K ^c   Vaarala, Markku H ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Androgen receptor; Gene expression regulation; Myosin VI; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; LUCIFERASE; MYOSIN VI; SMALL INTERFERING RNA; TESTOSTERONE; UVOMORULIN;

ARTICLE; CELL STRAIN LNCAP; DOWN REGULATION; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HORMONAL REGULATION; HORMONE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RNA INTERFERENCE;

ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LUCIFERASES; MALE; MAMMARY TUMOR VIRUS, MOUSE; MICE; MYOSIN HEAVY CHAINS; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; TESTOSTERONE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 70449381178     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000526     Document Type: Article

References (19)

1. Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA and Sweeney HL: Myosin VI is an actin-based motor that moves backwards. Nature 401: 505-508, 1999.
2. Aschenbrenner L, Naccache SN and Hasson T: Uncoated endocytic vesicles require the unconventional myosin, Myo6, for rapid transport through actin barriers. Mol Biol Cell 15: 2253-2263, 2004.
3. Yoshida H, Cheng W, Hung J, Montell D, Geisbrecht E, Rosen D, Liu J and Naora H: Lessons from border cell migration in the drosophila ovary: a role for myosin VI in dissemination of human ovarian cancer. Proc Natl Acad Sci USA 101: 8144-8149, 2004.
4. Millo H, Leaper K, Lazou V and Bownes M: Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis. Mech Dev 121: 1335-1351, 2004.
5. Vreugde S, Ferrai C, Miluzio A, Hauben E, Marchisio PC, Crippa MP, Bussi M and Biffo S: Nuclear myosin VI enhances RNA polymerase II-dependent transcription. Mol Cell 23: 749-755, 2006.
6. Dunn TA, Chen S, Faith DA, Hicks JL, Platz EA, Chen Y, Ewing CM, Sauvageot J, Isaacs WB, De Marzo AM and Luo J: A novel role of myosin VI in human prostate cancer. Am J Pathol 169: 1843-1854, 2006.
7. Demichelis F, Setlur SR, Beroukhim R, Perner S, Korbel JO, Lafargue CJ, Pflueger D, Pina C, Hofer MD, Sboner A, Svensson MA, Rickman DS, Urban A, Snyder M, Meyerson M, Lee C, Gerstein MB, Kuefer R and Rubin MA: Distinct genomic aberrations associated with ERG rearranged prostate cancer. Genes Chromosomes Cancer 48: 366-380, 2009.
8. Vaarala MH, Porvari K, Kyllonen A and Vihko P: Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression. Lab Invest 80: 1259-1268, 2000.
9. Takeda H, Nakamoto T, Kokontis J, Chodak GW and Chang C: Autoregulation of androgen receptor expression in rodent prostate: Immunohistochemical and in situ hybridization analysis. Biochem Biophys Res Commun 177: 488-496, 1991.
10. Wolf DA, Herzinger T, Hermeking H, Blaschke D and Horz W: Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. Mol Endocrinol 7: 924-936, 1993.
11. Geisbrecht ER and Montell DJ: Myosin VI is required for E-cadherin-mediated border cell migration. Nat Cell Biol 4: 616-620, 2002.
12. Buss F, Arden SD, Lindsay M, Luzio JP and Kendrick-Jones J: Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis. EMBO J 20: 3676-3684, 2001.
13. Hammes A, Andreassen TK, Spoelgen R, Raila J, Hubner N, Schulz H, Metzger J, Schweigert FJ, Luppa PB, Nykjaer A and Willnow TE: Role of endocytosis in cellular uptake of sex steroids. Cell 122: 751-762, 2005.
14. Ozanne DM, Brady ME, Cook S, Gaughan L, Neal DE and Robson CN: Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin. Mol Endocrinol 14: 1618-1626, 2000.
15. Velasco AM, Gillis KA, Li Y, Brown EL, Sadler TM, Achilleos M, Greenberger LM, Frost P, Bai W and Zhang Y: Identification and validation of novel androgen-regulated genes in prostate cancer. Endocrinology 145: 3913-3924, 2004.
16. Holzbeierlein J, Lal P, LaTulippe E, Smith A, Satagopan J, Zhang L, Ryan C, Smith S, Scher H, Scardino P, Reuter V and Gerald WL: Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol 164: 217-227, 2004.
17. Shang Y, Myers M and Brown M: Formation of the androgen receptor transcription complex. Mol Cell 9: 601-610, 2002.
18. Wang Q, Carroll JS and Brown M: Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell 19: 631-642, 2005.
19. Feldman BJ and Feldman D: The development of androgen-independent prostate cancer. Nat Rev Cancer 1: 34-45, 2001.