Pharmacokinetic and biodistribution studies of Amphotericin B microspheres

Journal of Microencapsulation

Volumn 26, Issue 7, 2009, Pages 627-634

  Angra, Pawan K ^a   Siddig, Aladin ^b   Nettey, Henry ^a   Desai, Nishil ^a   Oettinger, Carl ^c   D'Souza, Martin J ^a  

^a MERCER UNIVERSITY   (United States)

^b Robert C Byrd Center for Pharmacy Education   (United States)

^c Dialysis Clinic Inc   (United States)

Author keywords

Biodistribution; Bovine serum albumin; Polymers; Spray drying; Stealth microspheres

Indexed keywords

AMFOCAN; AMPHOTERICIN B; BOVINE SERUM ALBUMIN; CREATININE; MACROGOL 2000; MICROSPHERE; POTASSIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS LINKING; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; ELECTRON MICROSCOPY; ENCAPSULATION; LUNG; MALE; MYCOSIS; NONHUMAN; PARTICLE SIZE; POTASSIUM BLOOD LEVEL; RAT; ZETA POTENTIAL;

AMPHOTERICIN B; ANIMALS; ANTIFUNGAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LUNG; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; RATS; TISSUE DISTRIBUTION;

EID: 70449380799     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040802587173     Document Type: Article

References (16)

1. Absolom DR. 1986. Opsonins and dysopsonins: An overview. Methods Enzymol 132:281-381.
2. Absolom DR, Zingg W, Neumann AW. 1987. Protein adsorption to polymer particles: Role of surface properties. J Biomed Mater Res 21:161-171.
3. Boswell GW, Buell D, Bekersky I. 1998. AmBisome (liposomal amphotericin B): A comparative review. J Clin Pharmacol 38:583-592.
4. D'Souza MJ, Oettinger CW, Milton GV. 1999. Evaluation of microspheres containing cytokine neutralizing antibodies in endotoxemia. Drug Dev Ind Pharm 25:727-734.
5. Domb AJ, Linden G, Polacheck I, Benita S. 1996. Nystatin-dextran conjugates: Synthesis and characterization. J Polym Sci Part A Polym Chem 34:1229-1236.
6. Espada R, Josa JM, Valdespina S, Dea MA, Ballesteros MP, Alunda JM, et al. 2008. HPLC assay for determination of amphotericin B in biological samples. Biomed Chromatogr 22:402-407.
7. Harada S, Nakajima T, Komatsu T, Nakagawa T. 1978. Apparent molar volumes and adiabatic compressibilities of ethylene glycol derivatives in water at 5, 25, and 45-C. J Solut Chem 7:463-474.
8. Kiyosawa K. 1991. Volumetric properties of polyols (ethylene glycol, glycerol, meso-erythritol, xylitol and mannitol) in relation to their membrane permeability: Group additivity and estimation of the maximum radius of their molecules. Biochim Biophys Acta 1064:251-255.
9. Lincopan N, Mamizuka EM, Carmona-Ribeiro AM. 2005. Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments. J Antimicrob Chemother 55:727-734.
10. Moghimi SM, Patel HM. 1996. Altered tissue-specific opsonic activities and opsono-recognition of liposomes in tumour-bearing rats. Biochim Biophys Acta 1285:56-64.
11. Moghimi SM, Patel HM. 2002. Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition. J Contr Rel 78:55-65.
12. Murray L. Redbook 2006 Pharmacy's Fundamental Reference. Montvale, NJ: Thomson.
13. Ruiz-Arango A, Landolfo C. 2008. A novel approach to the diagnosis of left atrial appendage thrombus using contrast echocardiography and power Doppler imaging. Eur J Echocardiogr 9:329-333.
14. Sanchez-Brunete JA, Dea MA, Rama S, Bolas F, Alunda JM, Raposo R, et al. 2004. Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres. Antimicrob Agents Chemother 48:3246-3252.
15. Szebeni J. 1998. The interaction of liposomes with the complement system. Crit Rev Ther Drug Carrier Syst 15:57-88.
16. Tirosh O, Barenholz Y, Katzhendler J, Priev A. 1998. Hydration of polyethylene glycol-grafted liposomes. Biophys J 74:1371-1379.