Metabolomics: A new tool for the neonatologist

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 22, Issue SUPPL. 3, 2009, Pages 50-53

  Atzori, Luigi ^a,b   Antonucci, Roberto ^a   Barberini, Luigi ^a   Griffin, Julian L ^b   Fanos, Vassilios ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Diagnostics; Metabolomics; Newborn; Therapeutics

Indexed keywords

BIOLOGICAL MARKER;

ANALYTIC METHOD; HUMAN; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; NEONATOLOGY; NEWBORN DISEASE; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OUTCOME ASSESSMENT; PARTIAL LEAST SQUARES REGRESSION; PLASMA; POSTNATAL DEVELOPMENT; PREMATURITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; URINALYSIS;

HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; METABOLOMICS; NEONATOLOGY; URINALYSIS;

EID: 70449377323     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.1080/14767050903181500     Document Type: Review

References (8)

1. Nicholson JK, Lindon JC, Holmes E. ''Metabonomics'': Understanding the metabolic response of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999;29: 1181-1189.
2. Oliver SG, Functional genomics: Lessons from yeast. Philos Trans R Soc Lond B Biol Sci 2002;357:17-23.
3. Ellis DI, Dunn WB, Griffin JL, Allwood JW, Goodacre R. Metabolic fingerprinting as a diagnostic tool. Pharmacogenomics 2007;8:1243-1266.
4. Kristal BS, Shurubor YI, Kaddurah-Daouk R, Matson WR. High-performance liquid chromatography separations coupled with coulorimetric electrode array detectors: A unique approach to metabolomics. Methods Mol Biol 2007;358:159-174.
5. Lindon JC, Keun HC, Ebbels TM, Pearce JM, Holmes E, Nicholson JK. The Consortium for Metabonomic Toxicology (COMET): Aims, activities and achievements. Pharmacogenomics 2005;6:691-699.
6. Coen M, Holmes E, Lindon JC, Nicholson JK. NMRbased metabolic profiling and metabonomic approaches to problems in molecular toxicology. Chem Res Toxicol 2008;21: 9-27.
7. Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: A global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol 2008;48:653-683.
8. Atzori L. Antonucci R, Barberini L, Locci E, Cesare Marincola F, Scano P, Cortesi P, Agostiniani R, Weljie A, Lai A, et al. A 1H-NMR-based metabonomics profiling of urine in children affected by nephrouropathies. Front Biosci (accepted).