Vardenafil-induced relaxation and cyclic nucleotide levels in normal and obstructed rat urinary bladder

BJU International

Volumn 104, Issue 11, 2009, Pages 1740-1745

  Werkström, Viktoria ^a   Hedlund, Petter ^a,b   Lee, Tack ^c   Andersson, Karl Erik ^d  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c Inha University Hospital   (South Korea)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

CAMP; CGMP; Detrusor; Nerve function; Outflow obstruction; Smooth muscle; Urothelium

Indexed keywords

CARBACHOL; CYCLIC AMP; CYCLIC GMP; VARDENAFIL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER MUCOSA; BLADDER OBSTRUCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFECT; DRUG INHIBITION; ELECTROSTIMULATION; FEMALE; IC 50; ISOLATED ORGAN; LAMINA PROPRIA; NERVE POTENTIAL; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RADIOIMMUNOASSAY; RAT; SHAM PROCEDURE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SPRAGUE DAWLEY RAT; TISSUE PREPARATION; URETHRA; URETHRA OBSTRUCTION; UROTHELIUM;

ANIMALS; CYCLIC AMP; CYCLIC GMP; FEMALE; IMIDAZOLES; MUSCLE RELAXATION; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; TRIAZINES; URETHRAL OBSTRUCTION; URINARY BLADDER;

EID: 70449368561     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2009.08651.x     Document Type: Article

References (27)

1. Uckert S, Hedlund P, Andersson KE et al. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol 2006 50 : 1194 1207
2. Andersson KE. Neurotransmission and drug effects in urethral smooth muscle. Scand J Urol Nephrol Suppl 2001 207 : 26 34
3. Andersson KE, Wein AJ. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 2004 56 : 581 631
4. Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev 2006 58 : 488 520
5. Truss MC, Uckert S, Stief CG et al. Porcine detrusor cyclic nucleotide phosphodiesterase isoenzymes: characterization and functional effects of various phosphodiesterase inhibitors in vitro. Urology 1995 45 : 893 901
6. Truss MC, Uckert S, Stief CG, Kuczyk M, Jonas U. Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. I. Identification and characterization. Urol Res 1996 24 : 123 128
7. Tinel H, Stelte-Ludwig B, Hütter J, Sandner P. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. BJU Int 2006 98 : 1259 1263
8. Filippi S, Morelli A, Sandner P et al. Characterization and functional role of androgen-dependent PDE5 activity in the bladder. Endocrinology 2007 148 : 1019 1029
9. Truss MC, Stief CG, Uckert S et al. Phosphodiesterase 1 inhibition in the treatment of lower urinary tract dysfunction: from bench to bedside. World J Urol 2001 19 : 344 350
10. Werkström V, Svensson A, Andersson K-E et al. Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects. BJU Int 2006 98 : 414 423
11. Stief CG, Porst H, Neuser D, Beneke M, Ulbrich E. A randomised, placebo-controlled study to assess the efficacy of twice-daily vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol 2008 53 : 1236 1244
12. Lee T, Andersson KE, Streng T, Hedlund P. Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats - effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn 2008 27 : 88 95
13. McVary KT, Monnig W, Camps JL et al. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial. J Urol 2007 177 : 1071 1077
14. McVary KT, Roehrborn CG, Kaminetsky JC et al. Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 2007 177 : 1401 1407
15. Charlton RG, Morley AR, Chambers P, Gillespie JI. Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder. BJU Int 1999 84 : 953 960
16. Drake MJ, Hedlund P, Mills IW et al. Structural and functional denervation of human detrusor after spinal cord injury. Lab Invest 2000 80 : 1491 1499
17. Smet PJ, Jonavicius J, Marshall VR, de Vente J. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996 71 : 337 348
18. Gillespie JI, Markerink-van Ittersum M, De Vente J. Endogenous nitric oxide/cGMP signalling in the guinea pig bladder: evidence for distinct populations of sub-urothelial interstitial cells. Cell Tissue Res 2006 325 : 325 332
19. de Jongh R, van Koeveringe GA, van Kerrebroeck PE et al. Alterations to network of NO/cGMP-responsive interstitial cells induced by outlet obstruction in guinea-pig bladder. Cell Tissue Res 2007 330 : 147 160
20. Birder L. Role of the urothelium in bladder function. Scand J Urol Nephrol Suppl 2004 215 : 48 53
21. Masuda H, Okuno T, Suzuki M et al. Different distribution of nitric oxide synthase and soluble guanylyl cyclase activities in the detrusor and proximal urethra of the rabbit. J Urol 2002 168 : 2286 2290
22. Persson K, Pandita RK, Aszòdi A et al. Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I. Am J Physiol Regul Integr Comp Physiol 2000 279 : R1112 20
23. Uckert S, Stief CG, Lietz B et al. Possible role of bioactive peptides in the regulation of human detrusor smooth muscle - functional effects in vitro and immunohistochemical presence. World J Urol 2002 20 : 244 249
24. Gupta M, Kovar A, Meibohm B. The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction. J Clin Pharmacol 2005 45 : 987 1003
25. Lucas KA, Pitari GM, Kazerounian S et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000 52 : 375 414
26. Lau LC, Adaikan PG. Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum. Eur J Pharmacol 2006 541 : 184 190
27. Medina P, Segarra G, Torondel B et al. Inhibition of neuroeffector transmission in human vas deferens by sildenafil. Br J Pharmacol 2000 131 : 871 874