P.Asn176Lys and p.Met137Thr dimorphisms of the PRNP gene significantly decrease the susceptibility to classical scrapie in ARQ/ARQ sheep

Animal Genetics

Volumn 40, Issue 6, 2009, Pages 982-985

  Maestrale, C ^a   Carta, A ^b   Attene, S ^a   Galistu, A ^a   Santucciu, C ^a   Cancedda, M G ^a   Saba, M ^a   Sechi, S ^b   Patta, C ^a   Bandino, E ^a   Ligios, C ^a  

^a ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA SARDEGNA   (Italy)

^b AGRIS Sardinia ^*  (Italy)

Author keywords

PRNP gene; Scrapie; Sheep

Indexed keywords

ANIMAL; ARTICLE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; PRION; SCRAPIE; SHEEP;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; POLYMORPHISM, GENETIC; PRIONS; SCRAPIE; SHEEP;

OVIS ARIES; SARDA;

EID: 70449359762     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2009.01943.x     Document Type: Article

References (16)

1. Basler K., Oesch B., Scott M., Westaway D., Wälchli M., Groth D.F., McKinley M.P., Prusiner S.B. Weissmann C. (1986) Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell 46, 417 428.
2. Baylis M. Goldmann W. (2004) The Genetics of scrapie in sheep and goats. Current Molecular Medicine 4, 385 396.
3. Bossers A., Schreuder B.E.C., Muileman I.H., Belt P.B.G.M. Smits M.A. (1997) PrP genotype contributes to determining survival times of sheep with natural scrapie. The Journal of General Virology 77, 2669 2673.
4. Dawson M., Hoinville L.J., Hosie B.D. Hunter N. (1998) Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Information Group, Veterinary Record 142, 623 625.
5. Goldmann W., Baylis M., Chihota C., Stevenson E. Hunter N. (2005) Frequencies of PrP gene haplotypes in British sheep flocks and the implications from breeding programmes. Journal of Applied Microbiology 98, 1294 1302.
6. 171 increases resistance to experimental challenge with bovine spongiform encephalopathy agent. The Journal of General Virology 87, 3741 3745.
7. Hunter N. (1997) PrP genetics in sheep and the implications for scrapie and BSE. Trends in Microbiology 5, 331 334. (Pubitemid 27362297)
8. Hunter N., Foster J.D. Hope J. (1992) Natural scrapie in British sheep: breeds, ages and PrP gene polymorphisms. Veterinary Record 130, 389 392.
9. Hunter N., Goldmann W., Smith G. Hope J. (1994) The association of a codon 136 PrP gene variant with the occurrence of natural scrapie. Archives of Virology 137, 171 177.
10. Laegreid W.W., Clawson M.L., Heaton M.P., Green B.T., O'Rourke K.I. Knowles D.P. (2008) Scrapie Resistance in ARQ Sheep. Journal of Virology 82, 10318 10320.
11. Sc deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep pre-clinically affected with natural scrapie. Archives of Virology 15, 2007 2020.
12. Maestrale C., Vaccari G., Carcassola P., Melis P., Vargiu M.P., Saba M., Demontis F., Carta A. Ligios C. (2004) Standardizzazione di un metodo di discriminazione allelica TaqMan per la determinazione dei polimorfismi del gene della proteina prionica (PrP) ovina. Proceedings of the 16th National Meeting of Società Italiana di Patologia e di Allevamento degli Ovini e dei Caprini, Siena, Italy. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana, Rome.
13. Nonno R., Esposito E., Vaccari G., Conte M., Marcon S., Di Bari M., Ligios C., Di Guardo G. Agrimi U. (2003) Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep. Journal of Clinical Microbiology 41, 4127 4133.
14. SAS User's Guide (1999) Statistics, Version 8. SAS Inst Inc., Cary, NC, USA.
15. Thorgeirsdottir S., Sigurdarson S., Thorisson H.M., Georgsson G. Palsdottir A. (1999) PrP gene polymorphism and natural scrapie in Icelandic sheep. The Journal of General Virology 80, 2527 2534.
16. Vaccari G., D'Agostino C., Nonno R. et al. (2007) Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy. Journal of Virology 81, 7306 7309.