Evaluation of Sentinel Lymph Nodes for Melanoma Metastases by Pathologists

Clinics in Plastic Surgery

Volumn 37, Issue 1, 2010, Pages 101-112

  Shidham, Vinod B ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CytoJournal ^*  (United States)

Author keywords

Benign capsular nevi; Immunocytochemistry; Intraoperative cytology; MCW melanoma cocktail; Melanoma; Micrometastasis; Sentinel lymph node; Tyrosinase

Indexed keywords

MELAN A; MONOCLONAL ANTIBODY HMB 45; MONOPHENOL MONOOXYGENASE; PARAFFIN; PROTEIN S 100; TUMOR MARKER;

CANCER SURVIVAL; CLINICAL PROTOCOL; CYTOLOGY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HISTOPATHOLOGY; HUMAN; IMMUNOCYTOCHEMISTRY; LYMPHADENECTOMY; MELANOMA; METASTASIS; MICROMETASTASIS; PEROPERATIVE CARE; REVIEW; SENTINEL LYMPH NODE BIOPSY; SURVIVAL RATE; SURVIVAL TIME;

HUMANS; IMMUNOHISTOCHEMISTRY; INTRAOPERATIVE PERIOD; LYMPH NODES; LYMPHATIC METASTASIS; MELANOMA; SENTINEL LYMPH NODE BIOPSY; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 70449337709     PISSN: 00941298     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cps.2009.08.002     Document Type: Review

References (48)

1. Salti G.I., and Das Gupta T.K. Predicting residual lymph node basin disease in melanoma patients with sentinel lymph node metastases. Am J Surg 186 (2003) 98-101
2. Nowecki Z.I., Rutkowski P., Nasierowska-Guttmejer A., et al. Sentinel lymph node biopsy in melanoma patients with clinically negative regional lymph nodes-one institution's experience. Melanoma Res 13 (2003) 35-43
3. Manca G., Facchetti F., Pizzocaro C., et al. Nodal staging in localized melanoma. The experience of the Brescia Melanoma Unit. Br J Plast Surg 56 (2003) 534-539
4. Rutkowski P., Nowecki Z.I., Nasierowska-Guttmejer A., et al. Lymph node status and survival in cutaneous malignant melanoma-sentinel lymph node biopsy impact. Eur J Surg Oncol 29 (2003) 611-618
5. Wagner J.D., Ranieri J., Evdokimow D.Z., et al. Patterns of initial recurrence and prognosis after sentinel lymph node biopsy and selective lymphadenectomy for melanoma. Plast Reconstr Surg 112 (2003) 486-497
6. Zapas J.L., Coley H.C., Beam S.L., et al. The risk of regional lymph node metastases in patients with melanoma less than 1.0 mm thick: recommendations for sentinel lymph node biopsy. J Am Coll Surg 197 (2003) 403-407
7. Pu L.L., Wells K.E., Cruse C.W., et al. Prevalence of additional positive lymph nodes in complete lymphadenectomy specimens after positive sentinel lymphadenectomy findings for early-stage melanoma of the head and neck. Plast Reconstr Surg 112 (2003) 43-49
8. Reintgen D.S., Cruse C.W., Glass F., et al. In support of sentinel node biopsy as a standard of care for patients with malignant melanoma. Dermatol Surg 26 (2000) 1070-1072
9. Shidham V.B., Chang C.C., and Komorowski R. 'MCW melanoma cocktail' for evaluation of metastases in sentinel lymph nodes of cutaneous melanoma (invited review article). Expert Rev Mol Diagn 5 3 (2005) 281-290
10. Riber-Hansen R, Sjoegren P, Hamilton-Dutoit SJ, et al. Extensive pathological analysis of selected melanoma sentinel lymph nodes: high metastasis detection rates at reduced workload. Ann Surg Oncol 15(5):1492-1501.
11. Morton D.L., Thompson J.F., Cochran A.J., et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 355 (2006) 1307-1317
12. Gershenwald J.E., Thompson W., Mansfield P.F., et al. Multiinstitutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 17 (1999) 976-983
13. Shidham V.B., Qi D., Rao R., et al. Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with MCW melanoma cocktail-a mixture of monoclonal antibodies to MART-1, Melan-A, and Tyrosinase. BMC Cancer 3 1 (2003) 15. http://www.biomedcentral.com/qc/1471-2407/3/15 1-9. Available at:
14. Qi D., Acker S., Kampalath B., et al. Detection of melanoma micrometastases in sentinel lymph nodes: evaluation of MART-1 and Melan-A in comparison to traditionally used immunomarkers. [abstract no. 8]. Am J Clin Pathol 114 (2000) 629-659
15. Shidham V.B., Qi D., Acker S., et al. Evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma: higher diagnostic accuracy with Melan-A and MART-1 compared to S-100 protein and HMB-45. Am J Surg Pathol 25 (2001) 1039-1046
16. Shidham V., Macias V., Neuberg M., et al. Rapid intraoperative immunocytochemical evaluation of cutaneous melanoma sentinel lymph nodes for melanoma metastases with 'MCW Melanoma Cocktail'. [abstract no. 191]. Acta Cytol 47 (2003) 938
17. Gietema H.A., Vuylsteke R.J., de Jonge I.A., et al. Sentinel lymph node investigation in melanoma: detailed analysis of the yield from step sectioning and immunohistochemistry. J Clin Pathol 57 6 (2004) 618-620
18. Shidham V.B., Komorowski R., Macias V., et al. Optimization of immunostaining protocol for rapid intraoperative evaluation of imprint smears of melanoma sentinel lymph nodes with 'MCW melanoma cocktail'. CytoJournal 1 (2004) 2. http://www.cytojournal.com/content/1/1/2 10.1186/1742-6413-1-2 Free full text is Available at:
19. Cochran A.J., Ohsie S.J., and Binder S.W. Pathobiology of the sentinel node. Curr Opin Oncol 20 (2008) 190-195
20. Thomas J.M. Prognostic false-positivity of the sentinel node in melanoma. Nat Clin Pract Oncol 5 (2008) 18-23
21. Ellipse & parabola formulas, ask Dr Math: FAQ, the math forum @ Drexel. Available at: http://mathforum.org/dr.math/faq/formulas/faq.ellipse.html. Accessed: January 1, 2009. Archived by WebCite at: http://www.webcitation.org/5dVtGAVxS.
22. Haigh P.I., Lucci A., Turner R.R., et al. Carbon dye histologically confirms the identity of sentinel lymph nodes in cutaneous melanoma. Cancer 92 (2001) 535-541
23. Cochran A.J. Surgical pathology remains pivotal in the evaluation of 'sentinel' lymph nodes. Am J Surg Pathol 23 (1999) 1169-1172
24. Cochran A.J., Wen D.R., Herschman H.R., et al. Detection of S-100 protein as an aid to the identification of melanocytic tumors. Int J Cancer 30 (1982) 295-297
25. Gibbs J.F., Huang P.P., Zhang P.J., et al. Accuracy of pathologic techniques for the diagnosis of metastatic melanoma in sentinel lymph nodes. Ann Surg Oncol 6 (1999) 699-704
26. Jungbluth A.A., Iverson K., Coplan K., et al. T311-an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues. Pathol Res Pract 196 4 (2000) 235-242
27. Miettinen M., Fernandez M., Franssila K., et al. Microphthalmia transcription factor in the immunoh istochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers. Am J Surg Pathol 25 (2001) 205-211
28. Eudy G.E., Carlson G.W., Murray D.R., et al. Rapid immunohistochemistry of sentinel lymph nodes for metastatic melanoma. Hum Pathol 34 (2003) 797-802
29. Shidham V.B., Susnik B., Rao R.N., et al. HMB45 immunoreactive single cells in sentinel lymph nodes negative for melanoma micrometastases are mast cells. [abstract no. 1528]. Mod Pathol 17 Suppl 1 (2004) 1a-388a
30. Mahmood M.N., Lee M.W., Linden M.D., et al. Diagnostic value of HMB-45 and anti-Melan A staining of sentinel lymph nodes with isolated positive cells. Mod Pathol 15 12 (2002) 1288-1293
31. Yu L.L., Flotte T.J., Tanabe K.K., et al. Detection of microscopic melanoma metastases in sentinel lymph nodes. Cancer 86 (1999) 617-627
32. Yan S., and Brennick J.B. False-positive rate of the immunoperoxidase stains for MART1/MelanA in lymph nodes. Am J Surg Pathol 28 (2004) 596-600
33. Blaheta H.J., Ellwanger U., Schittek B., et al. Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma. J Invest Dermatol 114 (2000) 637-642
34. Blaheta H.J., Paul T., Sotlar K., et al. Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness. Br J Dermatol 145 (2001) 195-202
35. Ghossein R., and Rosai J. Polymerase chain reaction in the detection of micrometastases and circulating tumor cells. Cancer 78 (1996) 10-16
36. Ribe A., and McNutt N.S. S100A6 protein expression is different in Spitz nevi and melanomas. Mod Pathol 16 5 (2003) 505-511
37. Shivers S.C., Wang X., Li W., et al. Molecular staging of malignant melanoma: correlation with clinical outcome. JAMA 280 (1998) 1410-1415
38. Sung J., Li W., Shivers S., et al. Molecular analysis in evaluating the sentinel node in malignant melanoma. Ann Surg Oncol 8 Suppl 9 (2001) 29S-30S
39. Rimoldi D., Lemoine R., Kurt A.M., et al. Groupe Mélanome Lémanique. Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods. Melanoma Res 13 (2003) 511-520
40. Soo V., Shen P., Pichardo R., et al. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol 14 (2007) 1612-1617
41. Clary B.M., Lewis J.J., Brady M.S., et al. Should frozen section analysis of the sentinel node be performed in patients with melanoma?. Eur J Nucl Med 26 (1999) S68
42. Tanis P.J., Boom R.P., Koops H.S., et al. Frozen section investigation of the sentinel node in malignant melanoma and breast cancer. Ann Surg Oncol 8 (2001) 222-226
43. Creager A.J., Shiver S.A., Shen P., et al. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Cancer 94 (2002) 3016-3022
44. Hocevat M., Bracko M., Pogacnik A., et al. Role of imprint cytology in the intraoperative evaluation of sentinel lymph nodes for malignant melanoma. Eur J Cancer 39 (2003) 2173-2178
45. Stojadinovic A., Allen P.J., Clary B.M., et al. Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. Ann Surg 235 (2002) 92-98
46. Shidham V.B., Chang C.C., Rao R.N., et al. Immunostaining of cytology smears: a comparative study to identify the most suitable method of smear preparation and fixation with reference to commonly used immunomarkers. Diagn Cytopathol 29 (2003) 217-221
47. Shidham V., Kampalath B., and England J. Routine air drying of all the smears prepared during fine needle aspiration and intraoperative cytology studies. An opportunity to practice a unified protocol, offering the flexibility of choosing variety of staining methods. Acta Cytol 45 (2001) 60-68
48. Abrahamsen H.N., Hamilton-Dutoit S.J., Larsen J., et al. Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision. Cancer 100 8 (2004) 1683-1691