One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-His cells

Biophysical Journal

Volumn 97, Issue 8, 2009, Pages 2117-2127

  Inada, S ^a   Hancox, J C ^b   Zhang, H ^a   Boyett, M R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM FIBRILLATION; HEART ATRIUM MUSCLE; HEART STIMULATION; MATHEMATICAL MODEL; NONHUMAN; PACEMAKER; RABBIT; REENTRY ARRHYTHMIA; SINUS NODE;

EID: 70449120456     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.06.056     Document Type: Article

References (43)

1. Meijler, F. L., and M. J. Janse. 1988. Morphology and electrophysiology of the mammalian atrioventricular node. Physiol. Rev. 68:608-647.
2. Petrecca, K., and A. Shrier. 2000. Spatial distribution of ion channels, receptors, and innervation. In Atrial-AV Nodal Electrophysiology: A View from the Millennium. T. N. Mazgalev and P. J. Tchou, editors. Futura Publishing, New York. 89-105.
3. Boyett, M. R., J. Li, S. Inada, H. Dobrzynski, J. E. Schneider, et al. 2005. Imaging the heart: computer 3-dimensional anatomic models of the heart. J. Electrocardiol. 38:113-120. (Pubitemid 41436498)
4. Liu, Y., W. Zeng, M. Delmar, and J. Jalife. 1993. Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes. Circulation. 88:1634-1646. (Pubitemid 23296910)
5. Hancox, J. C., K. H. Yuill, J. S. Mitcheson, and M. K. Convery. 2003. Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node. Int. J. Bifurcat. Chaos. 13:3675-3691.
6. de Carvalho, A., and D. de Almeida. 1960. Spread of activity through the atrioventricular node. Circ. Res. 8:801-809.
7. Munk, A. A., R. A. Adjemian, J. Zhao, A. Ogbaghebriel, and A. Shrier. 1996. Electrophysiological properties of morphologically distinct cells isolated from the rabbit atrioventricular node. J. Physiol. 493:801-818.
8. Ren, F. X., X. L. Niu, Y. Ou, Z. H. Han, F. D. Ling, et al. 2006. Morphological and electrophysiological properties of single myocardial cells from Koch triangle of rabbit heart. Chin. Med. J. 119:2075-2084.
9. Billette, J. 1987. Atrioventricular nodal activation during periodic premature stimulation of the atrium. Am. J. Physiol. 252:H163-H177.
10. Medkour, D., A. E. Becker, K. Khalife, and J. Billette. 1998. Anatomic and functional characteristics of a slow posterior AV nodal pathway: role in dual-pathway physiology and reentry. Circulation. 98:164-174. (Pubitemid 28317897)
11. Greener, I. D., J. Tellez, H. Dobrzynski, M. Yamamoto, G. M. Graham, et al. 2009. Ion channel transcript expression at the rabbit atrioventricular conduction axis. Circ. Arrhythmia Electrophysiol. 2:305-315.
12. Zhang, H., A. V. Holden, I. Kodama, H. Honjo, M. Lei, et al. 2000. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am. J. Physiol. 279:H397-H421.
13. Lindblad, D. S., C. R. Murphey, J. W. Clark, and W. R. Giles. 1996. A model of the action potential and underlying membrane currents in a rabbit atrial cell. Am. J. Physiol. 271:H1666-H1696.
14. de Carvalho, A. P., W. C. Mello, and B. F. Hoffman. 1959. Electrophysiological evidence for specialized fiber types in rabbit atrium. Am. J. Physiol. 196:483-488.
15. de Groot, J. R., T. Veenstra, A. O. Verkerk, R. Wilders, J. P. Smits, et al. 2003. Conduction slowing by the gap junctional uncoupler carbenoxolone. Cardiovasc. Res. 60:288-297.
16. Efimov, I. R., V. P. Nikolski, F. Rothenberg, I. D. Greener, J. Li, et al. 2004. Structure-function relationship in the AV junction. Anat. Rec. 280:952-965.
17. Goy, J. J., and M. Fromer. 1991. Antiarrhythmic treatment of atrioventricular tachycardias. J. Cardiovasc. Pharmacol. 17 (Suppl ):S36-S40.
18. Mazgalev, T. N., S. Garrigue, K. A. Mowrey, Y. Yamanouchi, and P. J. Tchou. 1999. Autonomic modification of the atrioventricular node during atrial fibrillation: role in the slowing of ventricular rate. Circulation. 99:2806-2814. (Pubitemid 29250028)
19. Zipes, D. P., and C. Mendez. 1973. Action of manganese ions and tetrodotoxin on atrioventricular nodal transmembrane potentials in isolated rabbit hearts. Circ. Res. 32:447-454.
20. Dobrzynski, H., V. P. Nikolski, A. T. Sambelashvili, I. D. Greener, M. Yamamoto, et al. 2003. Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ. Res. 93:1102-1110.
21. Zhang, Y., and T. N. Mazgalev. 2004. Ventricular rate control during atrial fibrillation and AV node modifications: past, present, and future. Pacing Clin. Electrophysiol. 27:382-393.
22. Nikolski, V. P., S. A. Jones, M. K. Lancaster, M. R. Boyett, and I. R. Efimov. 2003. Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry. Circ. Res. 92:469-475.
23. Kleber, A. G., and Y. Rudy. 2004. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol. Rev. 84:431-488.
24. Patterson, E., and B. J. Scherlag. 2002. Anatomic and functional fast atrioventricular conduction pathway. J. Cardiovasc. Electrophysiol. 13:945-949.
25. Reid, M. C., J. Billette, K. Khalife, and R. Tadros. 2003. Role of compact node and posterior extension in direction-dependent changes in atrioventricular nodal function in rabbit. J. Cardiovasc. Electrophysiol. 14:1342-1350.
26. Lin, L. J., J. Billette, D. Medkour, M. C. Reid, M. Tremblay, et al. 2001. Properties and substrate of slow pathway exposed with a compact node targeted fast pathway ablation in rabbit atrioventricular node. J. Cardiovasc. Electrophysiol. 12:479-486.
27. Haissaguerre, M., F. Gaita, B. Fischer, D. Commenges, P. Montserrat, et al. 1992. Elimination of atrioventricular nodal reentrant tachycardia using discrete slow potentials to guide application of radiofrequency energy. Circulation. 85:2162-2175.
28. Lundstrom, T., and L. Ryden. 1990. Ventricular rate control and exercise performance in chronic atrial fibrillation: effects of diltiazem and verapamil. J. Am. Coll. Cardiol. 16:86-90.
29. Philippon, F., V. J. Plumb, and G. N. Kay. 1994. Differential effect of esmolol on the fast and slow AV nodal pathways in patients with AV nodal reentrant tachycardia. J. Cardiovasc. Electrophysiol. 5:810-817.
30. Watanabe, Y., and L. S. Dreifus. 1968. Sites of impulse formation within the atrioventricular junction of the rabbit. Circ. Res. 22:717-727.
31. Kirchhof, C. J., F. I. Bonke, M. A. Allessie, and W. J. Lammers. 1987. The influence of the atrial myocardium on impulse formation in the rabbit sinus node. Pflugers Arch. 410:198-203.
32. Hucker, W. J., M. L. McCain, J. I. Laughner, P. A. Iaizzo, and I. R. Efimov. 2008. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anat. Rec. (Hoboken). 291:204-215.
33. Li, J., I. D. Greener, S. Inada, V. P. Nikolski, M. Yamamoto, et al. 2008. Computer three-dimensional reconstruction of the atrioventricular node. Circ. Res. 102:975-985.
34. Inada, S., J. Li, H. Dobrzynski, I. Greener, J. Hancox, et al. 2008. Simulation of atrioventricular nodal reentry using detailed anatomical and action potential models. Physiological Society Main Meeting Abstracts. 86P.
35. 2+-tolerant myocytes isolated from the rabbit atrioventricular node. Pflugers Arch. 438:68-78.
36. o indicating the existence of two inward currents in cells of the rabbit atrioventricular node. Circ. Res. 39:326-336.
37. Akiyama, T., and H. A. Fozzard. 1979. Ca and Na selectivity of the active membrane of rabbit AV nodal cells. Am. J. Physiol. 236:C1-C8.
38. Nakayama, T., Y. Kurachi, A. Noma, and H. Irisawa. 1984. Action potential and membrane currents of single pacemaker cells of the rabbit heart. Pflugers Arch. 402:248-257.
39. Hirata, A. 1990. Effect of hypoxia on electrical activity of atrioventricular nodal cells and atrial cells of the rabbit's heart. J. Electrocardiol. 23:69-76. (Pubitemid 20101623)
40. Hewett, K. W., C. H. Gaymes, C. I. Noh, B. A. Ross, R. P. Thompson, et al. 1991. Cellular electrophysiology of neonatal and adult rabbit atrioventricular node. Am. J. Physiol. 260:H1674-H1684.
41. Guo, J., and A. Noma. 1997. Existence of a low-threshold and sustained inward current in rabbit atrio-ventricular node cells. Jpn. J. Physiol. 47:355-359.
42. Yi, K. H., and H. S. Han. 2000. Cellular electrophysiology of fast pathway ablation of rabbit atrioventricular node. J. Korean Med. Sci. 15:494-500.
43. Mazgalev, T. N., and P. J. Tchou. 2000. Surface potentials from the region of the atrioventricular node and their relation to dual pathway electrophysiology. Circulation. 101:2110-2117.