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Journal of Sulfur Chemistry
Volumn 30, Issue 6, 2009, Pages 578-580
A simple, economical, and catalyst-free oxidation of thiols to disulfides
Author keywords

Catalyst free; Disulfides; N bromosuccinimide; Oxidation; Thiols
Indexed keywords

DICHLOROMETHANE; SULFUR COMPOUNDS;
EID: 70449119065     PISSN: 17415993     EISSN: 17416000     Source Type: Journal    
DOI: 10.1080/17415990903148075     Document Type: Article
Times cited : (23)
References (22)
  • 22
    • 85194971989 scopus 로고    scopus 로고
    • General procedure for the preparation of disulfides: To the stirred solution of thiols (1 mmol) in dichloromethane (5 ml), NBS (0.5 mmol) was added. The resulting mixture was stirred at room temperature by the time indicated in Table 1. The progress of the reaction was monitored by TLC. After the completion of the reaction, CH2Cl2 (10 ml) was added and the mixture was washed successively with water (2 × 20 mL). The organic layer was separated and dried (Na2SO4). Evaporation of the solvent under reduced pressure gave almost pure product. Further purification was achieved by column chromatography on silica gel or recrystallization from EtOAc-hexane to give pure product in good to excellent yield (Table 1). The products were characterized by comparison of spectral data with those of authentic samples
    • General procedure for the preparation of disulfides: To the stirred solution of thiols (1 mmol) in dichloromethane (5 ml), NBS (0.5 mmol) was added. The resulting mixture was stirred at room temperature by the time indicated in Table 1. The progress of the reaction was monitored by TLC. After the completion of the reaction, CH2Cl2 (10 ml) was added and the mixture was washed successively with water (2 × 20 mL). The organic layer was separated and dried (Na2SO4). Evaporation of the solvent under reduced pressure gave almost pure product. Further purification was achieved by column chromatography on silica gel or recrystallization from EtOAc-hexane to give pure product in good to excellent yield (Table 1). The products were characterized by comparison of spectral data with those of authentic samples.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.