N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 11, 2009, Pages 4224-4233

  Bhasin, Shalender ^a   He, E Jiaxiu ^c   Kawakubo, Miwa ^b   Schroeder, E Todd ^c   Yarasheski, Kevin ^e   Opiteck, Gregory J ^d   Reicin, Alise ^d   Chen, Fabian ^d   Lam, Raymond ^d   Tsou, Jeffrey A ^d   Castaneda Sceppa, Carmen ^f   Binder, Ellen F ^e   Azen, Stanley P ^b   Sattler, Fred R ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUPRORELIN; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; TESTOSTERONE;

AGE DISTRIBUTION; AGED; ANDROGEN THERAPY; ARTICLE; BODY MASS; BODY WEIGHT; COMMUNITY LIVING; CONTROLLED STUDY; DRUG DOSE COMPARISON; DUAL ENERGY X RAY ABSORPTIOMETRY; EVENING DOSAGE; HORMONAL THERAPY; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MUSCLE MASS; MUSCLE STRENGTH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SKELETAL MUSCLE; TESTOSTERONE BLOOD LEVEL;

EID: 70449090500     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1434     Document Type: Article

References (40)

1. Bhasin S, Calof OM, Storer TW, Lee ML, Mazer NA, Jasuja R, Montori VM, Gao W, Dalton JT 2006 Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nat Clin Pract 2:146-159
2. Niemelä O 1985 Radioimmunoassays for type III procollagen aminoterminal peptides in humans. Clin Chem 31:1301-1304 (Pubitemid 16041918)
3. Niemelä O, Risteli L, Parkkinen J, Risteli J 1985 Purification and characterization of the N-terminal propeptide of human type III procollagen. Biochem J 232:145-150 (Pubitemid 16198994)
4. Prockop DJ, Kivirikko KI, Tuderman L, Guzman NA 1979 The biosynthesis of collagen and its disorders (first of two parts). N Engl J Med 301:13-23 (Pubitemid 9226521)
5. Nguyen TV, Nelson AE, Howe CJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK 2008 Within-subject variability and analytic imprecision of insulinlike growth factor axis and collagen markers: implications for clinical diagnosis and doping tests. Clin Chem 54:1268-1276
6. Nelson AE, Howe CJ, Nguyen TV, Leung KC, Trout GJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK 2006 Influence of demographic factors and sport type on GH-responsive markers in elite athletes. J Clin Endocrinol Metab 91:4424-4432 (Pubitemid 44833418)
7. Danne T, Grüters A, Schuppan D, Quantas N, Enders I, Weber B 1989 Relationship of procollagen type III propeptide-related antigens in serum to somatic growth in healthy children and patients with growth disorders. J Pediatr 114:257-260 (Pubitemid 19059120)
8. Verde GG, Santi I, Chiodini P, Cozzi R, Dallabonzana D, Oppizzi G, Liuzzi A 1986 Serum type III procollagen propeptide levels in acromegalic patients. J Clin Endocrinol Metab 63:1406-1410 (Pubitemid 17206438)
9. Erotokritou-Mulligan I, Bassett EE, Bartlett C, Cowan D, McHugh C, Seah R, Curtis B, Wells V, Harrison K, Sönksen PH, Holt RI 2008 The effect of sports injury on insulin-like growth factor-I and type 3 procollagen: implications for detection of GH abuse in athletes. J Clin Endocrinol Metab 93:2760-2763 (Pubitemid 352008548)
10. Nelson AE, Meinhardt U, Hansen JL, Walker IH, Stone G, Howe CJ, Leung KC, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK 2008 Pharmacodynamics of GH abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. J Clin Endocrinol Metab 93:2213-2222 (Pubitemid 351831538)
11. Garma T, Kobayashi C, Haddad F, Adams GR, Bodell PW, Baldwin KM 2007 Similar acute molecular responses to equivalent volumes of isometric, lengthening, or shortening mode resistance exercise. J Appl Physiol 102:135-143 (Pubitemid 46089759)
12. Longobardi S, Keay N, Ehrnborg C, Cittadini A, Rosén T, Dall R, Boroujerdi MA, Bassett EE, Healy ML, Pentecost C, Wallace JD, Powrie J, Jørgensen JO, Saccà L 2000 GH (GH) effects on bone and collagen turnover in healthy adults and its potential as a marker of GH abuse in sports: a double blind, placebo-controlled study. The GH-2000 Study Group. J Clin Endocrinol Metab 85:1505-1512 (Pubitemid 32293560)
13. Erotokritou-Mulligan I, Bassett EE, Kniess A, Sönksen PH, Holt RI 2007 Validation of the GH (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets. Growth Horm IGF Res 17:416-423 (Pubitemid 47324307)
14. Wallace JD, Cuneo RC, Lundberg PA, Rosén T, Jørgensen JO, Longobardi S, Keay N, Sacca L, Christiansen JS, Bengtsson BA, Sönksen PH 2000 Responses of markers of bone and collagen turnover to exercise, GH (GH) administration, and GH withdrawal in trained adult males. J Clin Endocrinol Metab 85:124-133
15. Powrie JK, Bassett EE, Rosen T, Jørgensen JO, Napoli R, Sacca L, Christiansen JS, Bengtsson BA, Sönksen PH 2007 Detection of GH abuse in sport. Growth Horm IGF Res 17:220-226
16. McHugh CM, Park RT, Sönksen PH, Holt RI 2005 Challenges in detecting the abuse of GH in sport. Clin Chem 51:1587-1593
17. Erotokritou-Mulligan I, Bassett EE, Cowan DA, Bartlett C, McHugh C, Sönksen PH, Holt RI 2009 Influence of ethnicity on IGF-I and procollagen III peptide (P-III-P) in elite athletes and its effect on the ability to detect GH abuse. Clin Endocrinol (Oxf) 70:161-168
18. Sattler F, Castaneda-Sceppa C, Binder E, Schroeder E, Wang Y, Bhasin S, Kawakubo M, Stewart Y, Yarasheski K, Ulloor J, Colletti P, Roubenoff R, Azen S 2009 Testosterone and GH improve body composition and muscle performance in older men. J Clin Endocrinol Metab 94:1991-2001
19. Schroeder ET, Castaneda-Sceppa C, Wang Y, Binder EF, Kawakubo M, Stewart Y, Storer T, Roubenoff R, Bhasin S, Yarasheski KE, Sattler FR, Azen SP 2007 Hormonal Regulators of Muscle and Metabolism in Aging (HORMA): design and conduct of a complex, double masked multicenter trial. Clin Trials (London, England) 4:560-571
20. Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Longstreth J, Berman N 2000 Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 85:4500-4510 (Pubitemid 32157624)
21. Lucidi P, Lauteri M, Laureti S, Celleno R, Santoni S, Volpi E, Angeletti G, Santeusanio F, De Feo P 1998 A dose-response study of GH (GH) replacement on whole body protein and lipid kinetics in GH-deficient adults. J Clin Endocrinol Metab 83:353-357 (Pubitemid 28496505)
22. Toogood AA, Shalet SM 1999 GH replacement therapy in the elderly with hypothalamic-pituitary disease: a dose-finding study. J Clin Endocrinol Metab 84:131-136
23. Amato G, Mazziotti G, Di Somma C, Lalli E, De Felice G, Conte M, Rotondi M, Pietrosante M, Lombardi G, Bellastella A, Carella C, Colao A 2000 Recombinant GH (GH) therapy in GH-deficient adults: a long-term controlled study on daily versus thrice weekly injections. J Clin Endocrinol Metab 85:3720-3725 (Pubitemid 30828582)
24. Fleck S 1997 Designing resistance training programs. In: Human kinetics. 2nd ed. Human Kinetics Publishers: Champaign, IL; 98-100
25. Schroeder ET, Wang Y, Castaneda-Sceppa C, Cloutier G, Vallejo AF, Kawakubo M, Jensky NE, Coomber S, Azen SP, Sattler FR 2007 Reliability of maximal voluntary muscle strength and power testing in older men. J Gerontol 62:543-549 (Pubitemid 47065694)
26. Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S 2006 Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab 91:136-144 (Pubitemid 43069129)
27. Sir-Petermann T, Codner E, Pérez V, Echiburú B, Maliqueo M, Ladró n de Guevara A, Preisler J, Crisosto N, Sánchez F, Cassorla F, Bhasin S 2009 Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab 94:1923-1930
28. Risteli J, Niemi S, Trivedi P, Mäentausta O, Mowat AP, Risteli L 1988 Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type III procollagen. Clin Chem 34:715-718 (Pubitemid 18129776)
29. Deley G, Kervio G, Van Hoecke J, Verges B, Grassi B, Casillas JM 2007 Effects of a one-year exercise training program in adults over 70 years old: a study with a control group. Aging Clin Exp Res 19:310-315 (Pubitemid 47496892)
30. Yarasheski KE 1994 GH effects on metabolism, body composition, muscle mass, and strength. Exercise and sport sciences reviews 22:285-312
31. Giannoulis MG, Sonksen PH, Umpleby M, Breen L, Pentecost C, Whyte M, McMillan CV, Bradley C, Martin FC 2006 The effects of GH and/or testosterone in healthy elderly men: a randomized controlled trial. J Clin Endocrinol Metab 91:477-484 (Pubitemid 43236912)
32. Blackman MR, Sorkin JD, Münzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St. Clair C, Pabst KM, Harman SM 2002 GH and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288:2282-2292 (Pubitemid 35291758)
33. Haukipuro K, Risteli L, Kairaluoma MI, Risteli J 1990 Aminoterminal propeptide of type III procollagen in serum during wound healing in human beings. Surgery 107:381-388 (Pubitemid 20135395)
34. Kurdy NM, Bowles S, Marsh DR, Davies A, France M 1998 Serology of collagen types I and III in normal healing of tibial shaft fractures. J Orthop Trauma 12:122-126 (Pubitemid 128452800)
35. Veitch SW, Findlay SC, Hamer AJ, Blumsohn A, Eastell R, Ingle BM 2006 Changes in bone mass and bone turnover following tibial shaft fracture. Osteoporos Int 17:364-372
36. Giannoulis MG, Boroujerdi MA, Powrie J, Dall R, Napoli R, Ehrnborg C, Pentecost C, Cittadini A, Jørgensen JO, Sonksen PH 2005 Gender differences in GH response to exercise before and after rhGH administration and the effect of rhGH on the hormone profile of fit normal adults. Clin Endocrinol (Oxf) 62:315-322 (Pubitemid 40380412)
37. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA 1993 Testosterone administration increases insulin-like growth factor-I levels in normal men. J Clin Endocrinol Metab 77:776-779 (Pubitemid 23298665)
38. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW 2001 Testosterone dose-response relationships in healthy young men. Am J Physiol 281:E1172-E1181 (Pubitemid 33775060)
39. Baker 3rd GT, Sprott RL 1988 Biomarkers of aging. Exp Gerontol 23:223-239
40. Bhasin S, Jasuja R 2009 Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care 12:232-240