In-vitro contraction of the equine aortic valve

Journal of Heart Valve Disease

Volumn 13, Issue 4, 2004, Pages 593-599

  Bowen, I Mark ^a   Marr, Celia M ^a   Chester, Adrian H ^b   Wheeler Jones, Caroline P D ^a   Elliott, Jonathan ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b HAREFIELD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANGIOTENSIN II; ENDOTHELIN 1; HYDRAZINE DERIVATIVE; MEDETOMIDINE; NORADRENALIN; PHENYLEPHRINE; PROSTAGLANDIN ENDOPEROXIDE; SCAVENGER; SEROTONIN; THROMBOXANE RECEPTOR; VASOCONSTRICTOR AGENT;

ANIMAL; ANIMAL MODEL; AORTA VALVE; ARTICLE; BIOLOGICAL MODEL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HEART CONTRACTION; HORSE; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICS;

ADRENERGIC ALPHA-AGONISTS; ANGIOTENSIN II; ANIMALS; AORTIC VALVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; FREE RADICAL SCAVENGERS; HORSES; HYDRAZINES; MEDETOMIDINE; MODELS, ANIMAL; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; PHENYLEPHRINE; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; RECEPTORS, THROMBOXANE; SEROTONIN; STATISTICS; VASOCONSTRICTOR AGENTS;

EID: 7044269333     PISSN: 09668519     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Chester AH, Misfeld M, Yacoub MH. Receptormediated contraction of aortic valve leaflets. J Heart Valve Dis 2000;9:250-254; discussion 254-255
2. Chester AH, Misfeld M, Sievers HH, Yacoub MH. Influence of 5-hydroxytryptamine on aortic valve competence in vitro. J Heart Valve Dis 2001;10:822-825; discussion 825-826
3. Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337581
4. Hensrud DD, Connolly HM, Grogan M, et al. Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine. Mayo Clin Proc 1999;74:1191-1197
5. Else RW, Holmes JR. Cardiac pathology in the horse. 2. Microscopic pathology. Equine Vet J 1972;4:57-62
6. Else RW, Holmes JR. Cardiac pathology in the horse. 1. Gross pathology. Equine Vet J 1972;4:1-8
7. Blissitt KJ, Bonagura JD. Colour flow Doppler echocardiography in normal horses. Equine Vet J Suppl 1995:47-55
8. Kawano H, Do YS, Kawano Y, et al. Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts. Circulation 2000;101:1130-1137 (Pubitemid 30146614)
9. Webber KT, Swamynathan SK, Guntaka RV, Sun Y. Angiotensin II and extracellular matrix hemostasis. Int J Biochem Cell Biol 1999;31:395-403
10. Dostal DE, Rothblum KN, Chemin MI, Cooper GR, Baker KM. Intracardiac detection of angiotensinogen and renin: A localized renin-angiotensin system in neonatal rat heart. Am J Physiol 1992;263:C838-C850
11. Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992;267:16066-16068
12. .AIi AE, Barrett JC, Eling TE. Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. Prostaglandins 1980;20:667-688
13. Lin PJ, Chang CH, Pearson PJ, et al. Thromboxane A2: An endothelium-derived vasoconstrictor in human internal mammary arteries. Ann Thorac Surg 1993;56:97-100 (Pubitemid 23227242)
14. Fuse I, Ootsuka T, Hattori A, Mito M, Shibata A. Vascular thromboxane formation in hemostasis mechanism: Correlation between bleeding time and vascular TXB2 in a patient with congenital platelet cyclo-oxygenase deficiency. Int J Hematol 1996;63:317-324 (Pubitemid 26173934)
15. Marron K, Yacoub MH, Polak JM, et al. Innervation of human atrioventricular and arterial valves. Circulation 1996;94:368-375 (Pubitemid 26266121)
16. Messier RH, Jr., Bass BL, AIy HM, et al. Dual structural and functional phenotypes of the porcine aortic valve interstitial population: Characteristics of the leaflet myofibroblast. J Surg Res 1994;57:1-21
17. Russell FD, Davenport AP. Characterization of the binding of endothelin ETB selective ligands in human and rat heart. Br J Pharmacol 1996;119:631-636 (Pubitemid 26356574)
18. .Clozel M, Gray GA, Breu V, Loffler BM, Osterwalder R. The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo. Biochem Biophys Res Commun 1992;186:867-873
19. Misfeld M, Morrison K, Sievers H, Yacoub MH, Chester AH. Localization of immunoreactive endothelin and characterization of its receptors in aortic cusps. J Heart Valve Dis 2002;11:472-476; discussion
20. .Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988;150:9-14
21. Elliott J. Alpha-adrenoceptors in equine digital veins: Evidence for the presence of both alphal and alpha2-receptors mediating vasoconstriction. J Vet Pharmacol Ther 1997;20:308-317 (Pubitemid 27316656)
22. Bailey SR, Elliott J. Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: Implications for pathogenesis of acute laminitis. Equine Vet J 1998;30:124-130 (Pubitemid 128526304)