Lower phenytoin serum levels in persons switched from brand to generic phenytoin

Neurology

Volumn 63, Issue 8, 2004, Pages 1494-1496

  Burkhardt, R T ^b   Leppik, Ilo E ^a,b   Blesi, K ^a   Scott, S ^a   Gapany, S R ^a   Cloyd, J C ^b  

^a MINCEP Epilepsy Care   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENERIC DRUG; PHENYTOIN;

ADULT; ARTICLE; BIOEQUIVALENCE; CLINICAL ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MARKETING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; SEIZURE;

EID: 7044264394     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000142091.47698.A2     Document Type: Article

References (10)

1. Nuwer MR, Browne TR, Dodson WE, et al. Generic substitutions for antiepileptic drugs. Neurology 1990;40:1647-1651.
2. Carter BL, Garnett WR, Pellock JM, Stratton MA, Howell JR. Effect of antacids on phenytoin bioavailability. Ther Drug Monit 1981;3:333-340.
3. Cloyd JC, Gumnit RJ, Lesar TS. Reduced seizure control due to spoiled phenytoin capsules. Ann Neurol 1979;7:191-192.
4. rd ed. Vancouver, WA: Applied Therapeutics, 1992;25:25-44.
5. Cacek AT. Review of alterations in oral phenytoin bioavailability associated with formulation, antacids, and food. Ther Drug Monit 1986;8:166-171.
6. Soryal I, Richens A. Bioavailability and dissolution of proprietary and generic formulations of phenytoin. J Neurol Neurosurg Psychiatry 1992;55:688-691.
7. Nitsche V, Mascher H, Schutz H. Comparative bioavailability of several phenytoin preparations marked in Austria. Int J Clin Pharmacol Ther 1984;22:104-107.
8. Melikiau AP, Straughn AB, Slywka GWA, Wyatt PL, Meyer MC. Bioavailability of 11 phenytoin products. J Pharmacokinet Biopharm 1977;5:133-146.
9. Wilder BJ, Leppik IE, Hietpas TJ, Cloyd JC, Randinitis EJ, Cook J. Effect of food on absorption of Dilantin Kapseals and Mylan extended phenytoin sodium capsules. Neurology 2001;57:582-589.
10. Leppik IE, Cloyd JC, Sawchuk RJ, Pepin SM. Compliance and variability of plasma phenytoin levels in epileptic patients. Ther Drug Monit 1979;1:474-483.