Do vascular endothelial growth factor and basic fibroblast growth factor promote phenytoin's wound healing effect in rat? An immunohistochemical and histopathologic study

Dermatologic Surgery

Volumn 30, Issue 10, 2004, Pages 1303-1309

  Turan, Mustafa ^a,b   Saraydyn, Serpil Ünver ^a   Bulut, H Eray ^a   Elagöz, Sahande ^a   Çetinkaya, Öge ^a   Karadayi, Kursat ^a   Canbay, Emel ^a   Sen, Metin ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b Faculty of Medicine ^*  (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGEN; DERMATOLOGICAL AGENT; PHENYTOIN; SODIUM CHLORIDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FIBROBLAST; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RAT STRAIN; SKIN CULTURE; SKIN INCISION; SKIN INJURY; STATISTICAL SIGNIFICANCE; WOUND CARE; WOUND HEALING;

ANIMALS; FIBROBLAST GROWTH FACTOR 2; IMMUNOHISTOCHEMISTRY; PHENYTOIN; RATS; RATS, WISTAR; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 7044251630     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2004.30404.x     Document Type: Article

References (35)

1. Woodbury DM. Effect of diphenylhydantoin on electrolytes and on sodium turnover in brain other tissue, of normal hypernatremic and postictal rats. Pharmacol Exp Ther 1955;115:74-95.
2. Woodbury DM, Swinyard EA. Diphenylhydantoin absorption, distribution and excretion. In: Woodbury DM, Penry JD, Schmidt E, eds. Antiepileptic Drugs. New York: Raven Press, 1972:113-23.
3. Yi SJ, Seitz PK, Copper CW. Inhibition of in vitro secretion of rat calcitonin by phenytoin. Fed Proc 1987;46:393-4.
4. Pace CS, Livingstone E. Ionic basis of phenytoin sodium inhibition of insulin secretion in pancreatic islets. Diabetes 1979;28:1077-82.
5. Pendse AK, Sharma A. Topical phenytoin in wound healing. Int J Dermatol 1993;32:214-7.
6. El Zayat SG. Preliminary experience with topical phenytoin in wound healing in a war zone. Mil Med 1989;154:178-80.
7. Modaghegh S, Salehian B, Tavasoli M. Use of phenytoin in healing of war and non-war wounds. Int J Dermatol 1989;28:347-50.
8. Lodha CS, Lohiya LM, Vyas RC. Role of phenytoin in healing of large abscess cavities. Br J Surg 1991;78:105-8.
9. Goebel RW Sodium diphenylhydantoin association with oral healing. J Oral Surg 1972;30:191-5.
10. DaCosta M, Regan M, Sader M, Leader M, Bouchier-Hayes D. Diphenylhydantoin sodium promotes early and marked angiogenesis and results in increased collagen deposition and tensile strength in healing wounds. Surgery 1998;123:287-93.
11. Shafer WG. Effect of dilantin sodium analogues on cell prolipheration in tissue culture. Proc Soc Exp Biol Med 1961;106:205-9.
12. Kolbert GS. Oral diphenylhydantoin in corneal wound healing in the rabbit. Am J Ophthalmol 1968;66:736-8.
13. Shapiro M. Acceleration of gingival wound healing in nonepileptic patients receiving diphenylhydantoin sodium. Exp Med Surg 1958;1:41-53.
14. Otto G, Ludewig R, Kotzschke HJ. Specific effect of phenytoin application on periodontal diseases. Stomatol DDR 1977;27:262-8.
15. Habibipour S, Oswald TM, Zhang F, et al. Effect of sodium diphenylhydantoin on skin wound healing in rats. Plast Reconstr Surg 2003;112:1620-7.
16. Nissen NN, Polverini PJ, Koch AE, et al. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 1998;152:1445-52.
17. Takamiya M, Saigusa K, Aoki Y. Immunohistochemical study of basic fibroblast growth factor and vascular endothelial growth factor expression for age determination of cutaneous wounds. Am J Forens Med Pathol 2002;23:264-7.
18. Peacock E, Von Winkle W. Wound Repair, 2nd ed. Philadelphia: Saunders, 1976:81-9.
19. Forrest L. Current concepts in soft connective tissue wound healing. Br J Surg 1983;70:133-40.
20. Hardy MA. The biology of scar formation. Phys Ther 1989;69:1014-24.
21. Robbins S, Cotron R, Vinay K. Healing and repair. In: Robbins S, Cotron R, eds. Pathologic Basis of Disease, 3rd ed. Philadelphia: Saunders, 1984:69-81.
22. Oxlund H, Christensen H, Seyer-Hansen M, Andreassen TT. Collagen deposition and mechanical strength of colon anastomoses and skin incisional wounds of rats. J Surg Res 1996;66:25-30.
23. Anstead M, Hart L. Phenytoin in wound healing. Ann Pharmacother 1996;30:68-75.
24. Muthukumarasamy MG, Sivakumar G. Topical phenytoin in diabetic foot ulcers. Diabetes Care 1991;14:909-11.
25. Rodriguez NE, Esparza AS, Andrade PJS, Espejo PI, Chapa AJR. Treatment of soft-tissue ulcerations with topical diphenylhydantoin. Invest Med Int 1983;10:184-6.
26. Vernillo AT, Schwartz NB. Stimulation of collagen and glycosaminoglycan production by phenytoin (5.5′-diphenylhydantoin) in monolayer cultures of mesenchymal cells derived from embryonic chick sternae. Arch Oral Biol 1986;31:819-22.
27. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989;161:851-8.
28. Kandel J, Bossy-Wetzel E, Radvanyi F, et al. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 1991;66:1095-104.
29. Grant M, Jerdan J, Merimee TJ. Insulin-like growth factor-I modulates endothelial cell chemotaxis. J Clin Endocrinol Metab 1987;65:370-1.
30. Dignass AU, Tsunekawa S, Podolsky DK. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 1994;106:1254-62.
31. Phillips PG, Birnby LM, Narendran A, Milonovich WL. Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface. Am J Physiol Lung Cell Mol Physiol 2001;281:278-90.
32. Morbidelli L, Chang CH, Douglas JG, et al. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 1996;270:411-5.
33. Grasselli F, Basini G, Bussolati S, Tamanini C. Effects of VEGF and bFGF on proliferation and production of steroids and nitric oxide in porcine granulosa cells. Reprod Domest Anim 2002;37:362-8.
34. Turan M, Saraydin SU, Canbay E, et al. Positive effects of phenytoin on experimental colonie anastomoses. Int J Colorectal Dis 2004;19:250-7.
35. Ehrlich HP, Tarver H, Hunt TK. Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis. Ann Surg 1973;177:222-7.