The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity

Immunology and Cell Biology

Volumn 82, Issue 5, 2004, Pages 462-470

  Xu, Dongmei ^a,d   Regner, Matthias ^a   Smith, Danny ^b   Ruby, Janet ^b   Johnstone, Ricky ^c   Müllbacher, Arno ^a  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d SHANDONG UNIVERSITY   (China)

Author keywords

Ectromelia; Immunity; Multi drug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBODY; CYTOKINE; GLYCOPROTEIN P; TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ECTROMELIA VIRUS; FEMALE; GENE; IMMUNITY; IN VITRO STUDY; INFECTION RESISTANCE; INFECTION SENSITIVITY; ION TRANSPORT; KNOCKOUT MOUSE; LIVER; LYMPH NODE; MACROPHAGE; MDR1A GENE; MORBIDITY; MORTALITY; MOUSE; MULTIDRUG RESISTANCE; NATURAL KILLER CELL; NONHUMAN; SPLEEN CELL; VIRUS TITRATION;

ANIMALIA; ECTROMELIA VIRUS;

EID: 7044235977     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0818-9641.2004.01274.x     Document Type: Article

References (33)

1. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993; 62: 385-427.
2. Klimecki WT, Futscher BW, Grogan TM, Dalton WS. P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 1994; 83: 2451-8.
3. Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full-length cDNA for the human 'MDR1 ' gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl Acad. Sci. USA 1987; 84: 3004-8.
4. Gros P, Croop J, Roninson I, Varshavsky A, Housman DE. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc. Natl Acad. Sci. USA 1986; 83: 337-41.
5. Devault A, Gros P. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol. CellBiol. 1990; 10: 1652-63.
6. Roninson IB, Chin JE, Choi KG et al. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc. Natl Acad. Sci. USA 1986; 83: 4538-42.
7. Gros P, Raymond M, Bell J, Housman D. Cloning and characterization of a second member of the mouse mdr gene family. Mol. Cell Biol. 1988; 8: 2770-8.
8. Smit JJ, Schinkel AH, Oude Elferink RP et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993; 75: 451-62.
9. van Helvoort A, Smith AJ, Sprang H et al. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996; 87: 507-17.
10. Crawford AR, Smith AJ, Hatch VC, Oude Elferink RP, Borst P, Crawford JM. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy, J. Clin. Invest. 1997; 100: 2562-7.
11. Schinkel AH, Smit JJ, van Tellingen O et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994; 77: 491-502.
12. Eisenbraun MD, Miller RA. mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice. J. Immunol. 1999; 163: 2621-7.
13. Croop JM, Raymond M, Haber D et al. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol. Cell Biol. 1989; 9: 1346-50.
14. Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J. Immunol. 1998; 161: 5733-44.
15. Seiden MV, Swenerton KD, Matulonis U et al. A phase II study of the MDR inhibitor biricodar (INCEL, VX-710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy. Gynecol. Oncol. 2002; 86: 302-10.
16. Solary E, Drenou B, Campos L et al. Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia. Blood 2003; 102: 1202-10.
17. Gruber A, Bjorkholm M, Brinch L et al. A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia. Leuk. Res. 2003; 27: 323-8.
18. Lee CG, Ramachandra M, Jeang KT, Martin MA, Pastan I, Gottesman MM. Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter. FASEB J. 2000; 14: 516-22.
19. Lucia MB, Cauda R, Landay AL, Malorni W, Donelli G, Ortona L. Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function. AIDS Res. Hum. Retroviruses 1995; 11: 893-901.
20. Raviv Y, Puri A, Blumenthal R. P-glycoprotein-overexpressing multidrug-resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane. FASEB J. 2000; 14: 511-5.
21. Drach J, Gsur A, Hamilton G et al. Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes. Blood 1996; 88: 1747-54.
22. Raghu G, Park SW, Roninson IB, Mechetner EB. Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes. Exp. Hematol. 1996; 24: 1258-64.
23. Randolph GJ, Beaulieu S, Pope M et al. A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels. Proc. Natl Acad. Sci. USA 1998; 95: 6924-9.
24. Mullbacher A, Hill AB, Blanden RV, Cowden WB, King NJ, Hla RT. Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity. J. Immunol. 1991; 147: 1765-72.
25. Fenner F. Mouse-Pox (infectious ectromelia of mice): a review. J. Immunol. 1949; 63: 341-73.
26. Callahan GN, Ferrone S, Poulik MD, Reisfeld RA, Klein J. Characterization of Ia antigens in mouse serum. J. Immunol. 1976; 117: 1351-5.
27. Mullbacher A, Ebnet K, Blanden RV et al. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc. Natl Acad. Sci. USA 1996; 93: 5783-7.
28. Zinkernagel RM, Haenseler E, Leist T, Cerny A, Hengartner H, Althage A, T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J. Exp. Med. 1986; 164: 1075-92.
29. Blanden RV. Mechanisms of cell-mediated immunity in viral infection. In: Brent, L, Holborow, J (eds). Progress in Immunology II. Clinical Aspects. I. Amsterdam: North Holland, 1974; p. 117-25.
30. Mullbacher A. Cell-mediated cytotoxicity in recovery from poxvirus infections. Rev. Med. Virol. 2003; 13: 223-32.
31. Karupiah G, Coupar BE, Andrew ME et al. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2. J. Immunol. 1990; 144: 290-8.
32. Blanden RV, Deak BD, McDevitt HO. Strategies in virus-host interactions. In: Blanden RV (ed.) Immunology of Virus Diseases. Curtin: Brolga Press, 1989; p. 125-38.
33. Moss B. Poxvirdae: The viruses and their replication. In: Fields BN, Knipe DM, Howley PM et al. (eds). Fields Virology, 3rd edn. Philadelphia: Lippincott-Raven, 1996; p. 2849-83.