A rapid, sensitive and validated method for the determination of ondansetron in human plasma by reversed-phase high-pressure liquid chromatography

Arzneimittel-Forschung/Drug Research

Volumn 54, Issue 10, 2004, Pages 655-659

  Chandrasekar, Durairaj ^a   Ramakrishna, Sistla ^a   Diwan, Prakash V ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

CAS 116002 70 1; Ondansetron, determination in human plasma, pharmacokinetics, reversed phase HPLC

Indexed keywords

ONDANSETRON;

ACCURACY; ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; HUMAN; PLASMA; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STANDARD; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 7044227451     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1297017     Document Type: Article

References (7)

1. Gregory, R. E., Ettinger, D. S., 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs 55, 173 (1998)
2. Hesketh, P. J., Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting. Cancer Invest. 18, 163 (2000)
3. Dixon, C. M., Colthup, P. V. Serabjit Singh, C. J. et al., Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metab. Dispos. 23, 1225 (1995)
4. Colthup, P. V., Felgate, C. C., Palmer, J. L. et al., Determination of ondansetron in plasma and its pharmacokinetics in the young and elderly. J. Pharm. Sc. 80, 868 (1991)
5. Liu, J., Stewart, J. T., High performance liquid chromatographic analysis of ondansetron enantiomers in human serum using a reversed-phase cellulose-based chiral stationary phase and solid-phase extraction. J. Chromatogr. B Biomed. Sci. Appl. 694, 179 (1997)
6. Wring, S. A., Rooney, R. M., Goddard, C. P. et al., A sensitive radioimmunoassay, combined with solid-phase extraction, for the sub-nanogram per ml determination of ondansetron in human plasma. J. Pharm. Biomed. Anal. 12, 361 (1994)
7. Kelly, J. W., He, L., Stewart, J.J., High performance liquid chromatographic separation of ondansetron enantiomers in serum using a cellulose-derivatized stationary phase and solid-phase extraction. J. Chromatogr. 622, 291 (1993)