Thrombosis during infancy and childhood: What we know and what we do not know

Hematology/Oncology Clinics of North America

Volumn 18, Issue 6 SPEC.ISS., 2004, Pages 1315-1338

  Journeycake, Janna M ^a,b   Manco Johnson, Marilyn J ^c,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Dallas   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ARGATROBAN; BLOOD CLOTTING FACTOR 8; ENOXAPARIN; ESTROGEN; HEPARIN; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; TISSUE PLASMINOGEN ACTIVATOR; WARFARIN;

BLEEDING; CANCER; CHILDHOOD; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL HEART DISEASE; DEEP VEIN THROMBOSIS; FIBRINOLYTIC THERAPY; GENE MUTATION; GENETIC POLYMORPHISM; GENETICS; HEMOSTASIS; HUMAN; INCIDENCE; INDWELLING CATHETER; INFANCY; INFECTION; LABORATORY DIAGNOSIS; LABORATORY TEST; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOPOROSIS; PATIENT MONITORING; PHLEBOGRAPHY; POSTTHROMBOSIS SYNDROME; PREVALENCE; PRIORITY JOURNAL; RADIODIAGNOSIS; REVIEW; REYE SYNDROME; RISK FACTOR; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; STROKE; THROMBOCYTOPENIA; THROMBOEMBOLISM; THROMBOPHILIA; THROMBOSIS;

EID: 7044224583     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2004.07.001     Document Type: Review

References (126)

1. M.W. Richardson, G.A. Allen, and P.E. Monahan Thrombosis in children: current perspectives and distinct challenges Thromb Haemost 88 2002 900 911
2. U. Nowak-Gottl, A. Kosch, and N. Schlegel Thromboembolism in newborns, infants and children Thromb Haemost 86 2001 464 474
3. M. Andrew Developmental hemostasis: relevance to hemostatic problems during childhood Semin Thromb Hemost 21 1995 341 354
4. F.R. Rosendaal Thrombosis in the young: epidemiology and risk factors. A focus on venous thrombosis Thromb Haemost 78 1997 1 6
5. R. Nuss, and M. Manco-Johnson Childhood thrombosis Pediatrics 96 1995 291 294
6. S. Ehrenforth, R. Junker, H.-G. Koch, W. Kreuz, N. Munchow, I. Scharrer for the Children Thrombophilia Study Group Multicenter evaluation of combined prothrombotic defects associated with thrombophilia in childhood Eur J Pediatr 158 Suppl 3 1999 S97 S104
7. G. Young, M. Manco-Johnson, J.C. Gill, D.M. DiMichele, M.D. Tarantino, and T. Abshire Clinical manifestations of the prothrombin G20210A mutation in children: a pediatric coagulation consortium study J Thromb Haemost 1 2003 958 962
8. M.J. Manco-Johnson Disorders of hemostasis in childhood: risk factors for venous thromboembolism Thromb Haemost 78 1997 710 714
9. M.P. Massicotte, D. Dix, P. Monagle, M. Adams, and M. Andrew Central venous catheter related thrombosis in children: analysis of the Canadian Registry of Venous Thromboembolic Complications J Pediatr 133 1998 770 776
10. M. David, and M. Andrew Venous thromboembolic complications in children J Pediatr 123 1993 337 346
11. J. Hirsh, and A.Y.Y. Lee How we diagnose and treat deep vein thrombosis Blood 99 2002 3102 3110
12. C. Male, P. Chait, J.S. Ginsberg, K. Hanna, M. Andrew, and J. Halton Comparison of venography and ultrasound for the diagnosis of deep vein thrombosis in the upper body in children Thromb Haemost 87 2002 593 597
13. F. Lordick, M. Hentrich, T. Decker, M. Hennig, H. Pohlmann, and R. Hartenstein Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study Br J Haematol 120 6 2003 1073 1078
14. V.E. Price, M. Carcao, B. Connolly, P. Chait, A. Daneman, and M. Temple A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia J Thromb Haemost 2 5 2004 737 742
15. G.G. Hartnell, L.A. Hughes, J.P. Finn, and H.E. Longmaid Magnetic resonance angiography of the central chest veins Chest 107 1995 1053 1057
16. S.C. Kaste, S.A. Gronemeyer, F.A. Hoffer, B.N. Mandrell, and J.A. Wilimas Pilot study of noninvasive detection of venous occlusions from central venous access devices in children treated for acute lymphoblastic leukemia Pediatr Radiol 29 1999 570 574
17. G. Palareti, C. Legnani, B. Cosmi, L. Valdre, B. Lunghi, and F. Bernardi Predictive value of d-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia Circulation 108 2003 313 318
18. N. Goldenberg, R. Knapp-Clevenger, and M.J. Manco-Johnson Elevated plasma factor VIII and D-dimer levels and poor outcomes of thrombosis in children N Engl J Med 351 2004 1081 1088
19. P. Monagle, A.D. Michelson, E. Bovill, and M. Andrew Antithrombotic therapy in children Chest 119 1 Suppl 2001 344S 370S
20. M. Freed, J. Keane, and A. Rosenthal The use of heparinization to prevent arterial thrombosis after percutaneous cardiac catheterization in children Circulation 50 1974 565 569
21. M.M. Bern, J.J. Lockich, S.R. Wallach, A. Bothe, P.N. Benotti, and C.F. Arkin Very low doses of warfarin can prevent thrombosis in central venous catheters Ann Intern Med 112 1990 423 428
22. M. Monreal, A. Alastrue, M. Rull, and X. Mira Upper extremity deep venous thrombosis in cancer patients with venous access devices-prophylaxis with a low molecular weight heparin (Fragmin) Thromb Haemost 75 1996 251 253
23. F. Newall, C. Barnes, H. Savoie, J. Campbell, and P. Monagle Warfarin therapy in children who require long-term total parenteral nutrition Pediatr 112 2003 e386 e388
24. P. Massicotte, J.A. Julian, M. Gent, K. Shields, V. Marzinotto, and B. Szechtman An open label randomized controlled trial of low molecular weight heparin for the prevention of central venous line-related thrombotic complications in children: the PROTEKT trial Thromb Res 109 2003 101 108
25. F. Streif, M. Andrew, V. Marzinotto, P. Massicotte, A.K.C. Chan, and J.A. Julian Analysis of warfarin therapy in pediatric patients: a prospective cohort study of 319 patients Blood 94 1999 3007 3014
26. G. Masci, M. Magagnoli, P.A. Zucali, L. Castagna, C. Carnaghi, and B. Sarina Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients: can it be safely associated with fluorouracil-based chemotherapy? J Clin Oncol 21 2003 736 739
27. D. Tormene, P. Simioni, P. Prandoni, F. Franz, P. Zerbinalli, and G. Tognin The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study Blood 100 2002 2403 2405
28. S. Middeldorp, J.R. Meinardi, M.M.W. Koopman, E.C.M. van Pampus, K. Hamulyak, and J. van der Meer A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism Ann Intern Med 135 2001 322 327
29. P. Monagle, M. Adams, M. Mahoney, K. Ali, D. Barnard, and M. Bernstein Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry Pediatr Res 47 2000 763 766
30. J.M. Journeycake, and G.R. Buchanan Thrombotic complications of central venous catheters in children Curr Opin Hematol 10 2003 369 374
31. D.Z. Xiang, E.K. Verbeken, V. Lommel, and I. De Wever Sleeve-related thrombosis: a new form of catheter-related thrombosis Thromb Res 104 2001 7 14
32. B. Tolar, and J.R. Gould The timing and sequence of multiple device-related complications in patients with long term indwelling Groshong catheters Cancer 78 1996 1308 1313
33. M. Choi, M.P. Massicotte, V. Marzinotto, A.K.C. Chan, J.L. Holmes, and M. Andrew The use of alteplase to restore patency of central venous lines in pediatric patients: a cohort study J Pediatr 139 2001 152 156
34. J.P. Timoney, D.M. Malkin, J.S. Leane, M.L. Groeger, D.L. Heaney, and M. Keefe Safe and cost effective use of alteplase for the clearance of occluded central venous access devices J Clin Oncol 20 2002 1918 1922
35. C. Male, P. Chait, M. Andrew, K. Hanna, J. Julian, and L. Mitchell Central venous line-related thrombosis in children: association with central venous line location and insertion technique Blood 101 2003 4273 4278
36. J.M. Journeycake, C.T. Quinn, K.L. Miller, J.L. Zajac, and G.R. Buchanan Catheter-related deep venous thrombosis in children with hemophilia Blood 98 2001 1727 1731
37. D. Glaser, D. Medeiros, N. Rollins, and G.R. Buchanan Catheter-related thrombosis in children with cancer J Pediatr 138 2001 255 259
38. M. Andrew, V. Marzinotto, P. Pencharz, and S. Zlotkin A cross-sectional study of catheter-related thrombosis in children receiving total parenteral nutrition at home J Pediatr 126 1995 358 363
39. I.I. Raad, M. Luna, S.M. Khalil, J.W. Costerton, C. Lam, and G.P. Bodey The relationship between the thrombotic and infectious complications of central venous catheters JAMA 271 1994 1014 1016
40. F. Lordick, M. Hentrich, T. Decker, M. Hennig, H. Pohlmann, and R. Hartenstein Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study Br J Haematol 120 6 2003 1073 1078
41. C.M. Pierce, A. Wade, and Q. Mok Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children Intensive Care Med 26 2000 967 972
42. K.J. Henrickson, R.A. Axtell, S.M. Hoover, S.M. Kuhn, J. Pritchett, and S.C. Kehl Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: a randomized, multicenter, double-blind trial J Clin Oncol 18 2000 1269 1278
43. J. Ingram, S. Weitzman, M.L. Greenberg, P. Parkin, and R. Filler Complications of indwelling venous access lines in the pediatric hematology patient: a prospective comparison of external venous catheters and subcutaneous ports Am J Pediatr Hematol Oncol 13 1991 130 136
44. V. Puel, and M. Caudry Superior vena cava thrombosis related to catheter malposition in cancer chemotherapy given through implanted ports Cancer 72 1993 2248 2252
45. P. Wacker, and I. Oberhansli Right atrial thrombosis associated with central venous catheters in children with cancer Med Pediatr Oncol 22 1994 53 57
46. C.M. Kowalski, and J.A. Kaufman Migration of central venous catheters: implications for initial catheter tip positioning J Vasc Interv Radiol 8 1997 443 447
47. S. Fuchs, and A. Pollak Central venous catheter mechanical irritation of the right atrial free wall: a cause for thrombus formation Cardiology 91 1999 169 172
48. S.T. Mokrohisky, R.L. Levine, J.D. Blumhagen, and R.L. Wesenberg Low positioning of umbilical-artery catheters increases associated complications in newborn infants N Engl J Med 299 1978 561 564
49. R. Bambauer, and R. Inniger Complications and side effects associated with large-bore catheters in the subclavian and internal jugular veins Artif Organs 18 1994 318 321
50. O. Egeberg Thrombophilia caused by inheritable deficiency of blood antithrombin Scand J Clin Lab Invest 17 1965 92
51. J.H. Griffin, B. Evatt, and T.S. Zimmerman Deficiency of protein C in congenital thrombotic disease J Clin Invest 68 1981 1370 1373
52. H.P. Schwarz, M. Fischer, P. Hopmeier, M.A. Batard, and J.H. Griffin Plasma protein S deficiency in familial thrombotic disease Blood 64 1984 1297 1300
53. B. Bjarke, P. Herin, and M. Blomback Neonatal aortic thrombosis. A possible clinical manifestation of congenital antithrombin deficiency Acta Paediatr Scand 63 1974 297 301
54. H.E. Branson, R. Marble, and J. Katz Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant Lancet 105 1983 409 413
55. V. DeStefano, G. Leone, R. Ferrelli, G. Marietti, G. Tortorolo, and B. Bizzi Severe deep vein thrombosis in a 2-year-old child with protein S deficiency Thromb Haemost 58 1987 1089
56. U. Nowak-Gottl, A. Dubbers, D. Kececioglu, H.G. Koch, S. Kotthoff, and J. Runde Factor V Leiden, protein C, and lipoprotein (a) in catheter-related thrombosis in childhood: a prospective study J Pediatr 131 1997 608 612
57. M.T. Sifontes, R. Nuss, S.P. Hunger, J. Waters, L.J. Jacobson, and M. Manco-Johnson Activated protein C resistance and the factor V Leiden mutation in children with thrombosis Am J Hematol 57 1998 29 32
58. R. Koster, A.D. Blann, E. Briet, J.P. Vandenbroucke, and F.R. Rosendaal Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis Lancet 345 1995 152 155
59. J. O'Donnell, A.D. Mumford, R.A. Manning, and M. Laffan Elevation of factor VIII: C in venous thromboembolism is persistent and independent of the acute phase response Thromb Haemost 83 2000 10 13
60. J.S. Levine, W. Branch, and J. Rauch The antiphospholipid antibody syndrome N Engl J Med 346 2002 752 763
61. M.J. Manco- Johnson, and R. Nuss Lupus anticoagulant in children with thrombosis Am J Hematol 48 1995 240 243
62. R. Nuss, T. Hays, U. Chudgar, and M. Manco-Johnson Antiphospholipid antibodies and coagulation regulatory protein abnormalities in children with pulmonary emboli J Pediatr Hematol/Oncol 19 1997 202 207
63. C. Burk, L. Miller, S. Handler, and A. Cohen Preoperative history and coagulation screening in children undergoing tonsillectomy Pediatr 89 1992 691 695
64. P. Mathew, M. Manco-Johnson, J.J. Hutter, J. Hanrahan, R. Knapp-Clevenger, and B. Miller Early clot recurrence or progression is not increased in children with genetic thrombophilia-preliminary results from the Regional Thrombophilia Registry Eight and Ten (the ReTREAT Study) Blood 102 2003 548a
65. A. van Hylckama Vlieg, I.K. van der Linder, R.M. Bertina, and F.R. Rosendaal High levels of factor IX increase the risk of venous thrombosis Blood 95 2000 3678 3682
66. J.C. Meijers, W.L. Tekelenburg, B.N. Bouma, R.M. Bertina, and F.R. Rosendaal High levels of coagulation factor XI as a risk factor for venous thrombosis N Engl J Med 342 2000 696 701
67. D.A. Lane, and P.J. Grant Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease Blood 95 2000 1517 1532
68. W.E. Hathaway, and J. Bonnar Hemostatic disorders of the pregnant woman and newborn infant 1987 Elsevier Science Publishing Company New York
69. M.J. Manco- Johnson, and R. Nuss Thrombophilia in the infant and child Adv Pediatr 48 2001 363 384
70. L.G. Mitchell, A.H. Sutor, and M. Andrew Hemostasis in childhood acute lymphoblastic leukemia: coagulopathy induced by disease and treatment Semin Thromb Hemost 21 1995 390 400
71. K.A. Bauer The thrombophilias: well-defined risk factors with uncertain therapeutic implications Ann Intern Med 135 2001 367 373
72. J. Zimbelman, J. Lefkowitz, C. Schaeffer, T. Hays, M. Manco-Johnson, and C. Manhalter Unusual complications of warfarin therapy: skin necrosis and priapism J Pediatr 137 2000 266 268
73. M.M. McDonald, L.J. Jacobson, W.W. Hay Jr, and W.E. Hathaway Heparin clearance in the newborn Pediatr Res 15 1981 1015 1018
74. M.M. McDonald, and W.E. Hathaway Anticoagulant therapy by continuous heparinization in newborn and older infants J Pediatr 101 1982 451 457
75. D. Menache, J.P. O'Malley, J.B. Schorr, B. Wagner Williams C and the Cooperative Study Group Evaluation of the safety, recovery, half-life and clinical efficacy of antithrombin III (human) in patients with hereditary antithrombin deficiency Blood 75 1990 33 39
76. R.A. Marlar, R.R. Montgomery, and A.W. Broekmans Diagnosis and treatment of homozygous protein C deficiency J Pediatr 114 1989 528 534
77. E. Melissari, and V.V. Kakkar Congenital severe protein C deficiency in adults Br J Haematol 72 1989 222 228
78. M. Dreyfus, M. Masterson, M. David, G.E. Rivard, F.M. Muller, and W. Kreuz Replacement therapy with a monoclonal antibody purified protein C concentrate in newborns with severe congenital protein C deficiency Semin Thromb Hemost 21 1995 371 381
79. A. Antovic, M. Blomback, K. Bremme, M. ven Rooijen, and S. He Increased hemostasis potential persists in women with previous thromboembolism with or without APC resistance J Thromb Haemost 1 2003 2531 2535
80. M.F. Hockin, K.C. Jones, S.J. Everse, and K.G. Mann A model for the stoichiometric regulation of blood coagulation JBC 277 2002 18322 18333
81. K.A. Bauer, F.R. Rosendaal, and J.A. Heit Hypercoagulability: too many tests, too much conflicting data Hematology (Am Soc Hematol Educ Prog) 2002 353 368
82. I.D. Walker Factor V Leiden: should all women be screened prior to commencing the contraceptive pill? Blood Rev 13 1999 8 13
83. F.R. Rosendaal, M. Vessey, A. Rumley, E. Daly, M. Woodward, and F.M. Helmerhorst Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis Br J Haematol 116 4 2002 851 854
84. L.M. Reich, M. Bower, and N.S. Key Role of the geneticist in testing and counseling for inherited thrombophilia Genet Med 5 2003 133 143
85. D. Green Genetic hypercoagulability: screening should be an informed choice Blood 98 2001 20
86. M. Makris, F.R. Rosendaal, and F.E. Preston Familial thrombophilia: genetic risk factors and management J Intern Med Suppl 740 1997 9 15
87. M. Mannucci Genetic hypercoagulability: prevention suggests testing family members Blood 98 2001 21 22
88. M. Andrew, A.D. Michelson, E. Bovill, M. Leaker, and M.P. Massicotte Guidelines for antithrombotic therapy in pediatric patients J Pediatr 132 1998 575 588
89. D. Dix, M. Andrew, V. Marzinotto, K. Charpentier, S. Bridge, and P. Monagle The use of low molecular weight heparin in pediatric patients: a prospective cohort study J Pediatr 136 2000 439 445
90. M. Wang, T. Hays, V. Balasa, R. Bagatell, R. Gruppo, E.F. Grabowski for the Pediatric Coagulation Consortium Low-dose tissue plasminogen activator thrombolysis in children J Pediatr Hematol/Oncol 25 2003 379 386
91. R. Zwerdling, and J. Borwn Pulmonary embolism in children: risks and prevention JAMA 265 1991 2888
92. M.T. Derish, D.W. Smith, and L.R. Frankel Venous catheter thrombus formation and pulmonary embolism in children Pediatr Pulmonol 20 1995 349 354
93. M. Arima, T. Kanoh, A. Takagi, K. Tanimoto, T. Oigawa, and S. Matsuda Clinical features of acute pulmonary embolism in younger patients Circ J 67 2003 330 333
94. S.R. Kahn, and J.S. Ginsberg The post-thrombotic syndrome: current knowledge, controversies and directions for future research Blood Rev 16 2002 155 165
95. R.B. Rutherford Pathogenesis and pathophysiology of the post-thrombotic syndrome: clinical implications Semin Vasc Surg 9 1996 21 25
96. U.K. Franzeck, I. Schalch, and A. Bollinger On the relationship between changes in the deep veins evaluated by duplex sonography and the postthrombotic syndrome 12 years after deep vein thrombosis Thromb Haemost 77 1999 1109 1112
97. P. Prandoni, A.W.A. Lensing, M.H. Prins, E. Bernardi, A. Marchiori, and P. Bagatella Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism Ann Intern Med 137 2002 955 960
98. H.J. Welch, C.M. Young, A.B. Semegran, M.D. Iafrati, W.C. Mackey, and T.F. O'Donnell Jr Duplex assessment of venous reflux and chronic venous insufficiency: the significance of deep venous reflux J Vasc Surg 24 1996 755 762
99. M.H. Meissner, R.A. Manzo, R.O. Befgelin, A. Markel, and D.E. Strandness Deep venous insufficiency: the relationship between lysis and subsequent reflux J Vasc Surg 18 1993 596 608
100. T.F. O'Donnell, D.A. Rosenthal, A.D. Callow, and B.L. Ledig Effect of elastic compression on venous hemodynamics in postphlebitic limbs JAMA 242 1979 2766 2768
101. M.J. Manco-Johnson, R. Knapp-Clevenger, B. Miller, and T. Hays Post-thrombotic syndrome (PTS) in children: validation of a new pediatric outcome instrument and results in a comprehensive cohort of children with extremity deep vein thrombosis (DVT) Blood 102 2003 553a
102. M.J. Manco-Johnson, R. Nuss, T. Hays, W. Krupski, J. Drose, and M.L. Manco-Johnson Combined thrombolytic and anticoagulant therapy for venous thrombosis in children J Pediatr 136 2000 446 453
103. M. Hausler, D. Hubner, T. Delhaas, and E.G. Muhler Longterm complications of inferior vena cava thrombosis Arch Dis Child 85 2001 228 233
104. S. Kuhle, B. Koloshuk, V. Marzinotto, M. Bauman, P. Massicotte, and M. Andrew A cross-sectional study evaluating post-thrombotic syndrome in children Thromb Res 111 2003 227 233
105. J.M. Journeycake, D.A. Eshelman, and G.R. Buchanan Post-thrombotic syndrome following central venous catheter use in childhood cancer survivors [abstract] Blood 102 2003 2031
106. G. de Veber Arterial ischemic strokes in infants and children: an overview of current approaches Semin Thromb Haemost 29 2003 567 573
107. K. Kurnik, A. Kosch, R. Strater, R. Schobess, C. Heller Nowak-Gottl U for the Childhood Stroke Study Group Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study Stroke 34 2003 2887 2893
108. G. de Veber, M. Andrew, C. Adams, B. Bjornson, F. Booth, and D.J. Buckley Cerebral sinovenous thrombosis in children N Engl J Med 345 2001 417 423
109. A.K.C. Chan, and G. de Veber Prothrombotic and ischemic stroke in children Semin Pediatr Neurol 7 2000 301 308
110. F.J. Kirkham Is there a genetic basis for pediatric stroke? Curr Opin Pediatr 15 2003 547 558
111. G. de Veber, P. Monagle, A. Chan, D. MacGregor, R. Curtis, and S. Lee Prothrombotic disorders in infants and children with cerebral thromboembolism Arch Neurol 55 1998 1539 1543
112. S. Chabrier, B. Husson, P. Lasjaunias, P. Landrieu, and M. Tardieu Stroke in childhood: outcome and recurrence risk by mechanism in 59 patients J Child Neurol 15 2000 290 294
113. R. Strater, S. Becker, A. von Eckardsteini, A. Heinecke, S. Gutsche, and R. Junker Prospective assessment of risk factors for recurrent stroke during childhood-a 5-year follow-up study Lancet 360 2002 1540 1545
114. V. Ganesen, W.K. Chong, T.C. Cox, S.J. Chawda, M. Prengler, and F.J. Kirkham Posterior circulation stroke in childhood: risk factors and recurrence Neurology 59 2002 1552 1556
115. E. Mercuri, A. Barnett, M. Rutherford, A. Guzzetta, L. Haataja, and G. Cioni Neonatal cerebral infarction and neuromotor outcome at school age Pediatrics 113 2004 95 100
116. M. Steinlin, K. Roellin, and G. Schroth Long-term follow-up after stroke in childhood Eur J Pediatr 163 2004 245 250
117. G. de Veber, D. MacGregor, R. Curtis, and S. Mayank Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis J Child Neurol 15 2000 316 324
118. A.M. Hogan, F.J. Kirkham, and E.B. Isaacs Intelligence after stroke in childhood: review of the literature and suggestions for future research J Child Neurol 15 2000 325 332
119. ATLANTIS, ECASS, and NINDS rt-PA Study Group Investigators Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS and NINDS rt-PA stroke trials Lancet 363 2004 768 774
120. R. Kay, K.S. Wong, Y.L. Yu, Y.W. Chan, T.H. Tsoi, and A.T. Ahuja Low molecular-weight heparin for the treatment of acute ischemic stroke N Engl J Med 333 1995 1588 1593
121. B.H. Chong Heparin-induced thrombocytopenia J Thromb Haemost 1 2003 1471 1478
122. T.E. Warkentin Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban Thromb Res 110 2003 73 82
123. A.F. Klenner, N. Lubenow, R. Raschke, and A. Greinacher Heparin-induced thrombocytopenia in children: 12 new cases and a review of the literature Thromb Haemost 91 2004 719 724
124. F. Cetta, L.C. Graham, L.L. Wrona, M.J. Arruda, and J. Walenga Argatroban use during pediatric interventional cardiac catheterization Catheter Cardiovasc Interv 61 2004 147 149
125. S.R. Deitcher, A.P. Topoulos, J.R. Bartholomew, and M.R. Kichuk-Chrisant Lepirudin anticoagulation for heparin-induced thrombocytopenia J Pediatr 140 2002 264 266
126. J.E. Dalen Pulmonary embolism: what have we learned since Virchow?: treatment and prevention Chest 122 2002 1801 1817