Expression of heterologous antigens in commensal Neisseria spp.: Preservation of conformational epitopes with vaccine potential

Infection and Immunity

Volumn 72, Issue 11, 2004, Pages 6511-6518

  O'Dwyer, Clíona A ^a   Reddin, Karen ^b   Martin, Denis ^c   Taylor, Stephen C ^b   Gorringe, Andrew R ^b   Hudson, Michael J ^b   Brodeur, Bernard R ^c   Langford, Paul R ^a   Kroll, J Simon ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; PORIN; VACCINE;

ANTIGEN EXPRESSION; ARTICLE; BACTERIAL MEMBRANE; COMMENSALISM; CONFORMATIONAL TRANSITION; IMMUNE RESPONSE; MEMBRANE VESICLE; NEISSERIA; NEISSERIA MENINGITIDIS; NONHUMAN; OPSONIZATION; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRAIN DIFFERENCE; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE; CONJUGATION, GENETIC; CYTOPLASMIC VESICLES; EPITOPES; FLOW CYTOMETRY; HUMANS; IMMUNIZATION, PASSIVE; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; MICE; NEISSERIA; NEISSERIA MENINGITIDIS, SEROGROUP B; OPSONIN PROTEINS; PHAGOCYTOSIS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 7044224568     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.11.6511-6518.2004     Document Type: Article

References (30)

1. Bjune, G., E. A. Hoiby, J. K. Gronnesby, O. Arnesen, J. H. Fredriksen, A. Halstensen, E. Holten, A. K. Lindbak, H. Nokleby, E. Rosenqvist, et al. 1991. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet 338:1093-1096.
2. Blakebrough, I. S., B. M. Greenwood, H. C. Whittle, A. K. Bradley, and H. M. Gilles. 1982. The epidemiology of infections due to Neisseria meningitidis and Neisseria lactamica in a northern Nigerian community. J Infect. Dis. 146:626-637.
3. Brodeur, B. R., D. Martin, S. Rioux, N. Charland, and J. Hamel. 2003. Universal proteins as an alternative bacterial vaccine strategy, p. 12-29. In R. W. Ellis and B. R. Brodeur (ed.), New bacterial vaccines. Kluwer Academic/ Plenum Publishers, Amsterdam, The Netherlands.
4. Cadieux, N., M. Plante, C. R. Rioux, J. Hamel, B. R. Brodeur, and D. Martin. 1999. Bactericidal and cross-protective activities of a monoclonal antibody directed against Neisseria meningitidis NspA outer membrane protein. Infect Immun. 67:4955-4959.
5. Gold, R., I. Goldschneider, M. L. Lepow, T. F. Draper, and M. Randolph. 1978. Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. J Infect. Dis. 137:112-121.
6. Hou, V. C., G. R. Moe, Z. Raad, T. Wuorimaa, and D. M. Granoff. 2003. Conformational epitopes recognized by protective antineisserial surface protein A antibodies. Infect. Immun. 71:6844-6849.
7. Jones, D. M., and E. B. Kaczmarski. 1995. Meningococcal infections in England and Wales: 1994. Commun. Dis. Rep. CDR Rev. 5:R125-R130.
8. Lehmann, A. K., A. Halstensen, and C. F. Bassoe. 1998. Flow cytometric quantitation of human opsonin-dependent phagocytosis and oxidative burst responses to meningococcal antigens. Cytometry 33:406-413.
9. Lehmann, A. K., A. Halstensen, J. Hoist, and C. F. Bassoe. 1997. Functional assays for evaluation of serogroup B meningococcal structures as mediators of human opsonophagocytosis. J. Immunol Methods 200:55-68.
10. Martin, D., N. Cadieux, J. Hamel, and B. R. Brodeur. 1997. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. J. Exp. Med. 185:1173-1183.
11. Martin, D., C. R. Rioux, E. Cloutier, G. Leblanc, J. Carbonneau, J. Hamel, and B. R. Brodeur. 2002. Presented at the 13th International Pathogenic Neisseria Conference, Oslo, Norway.
12. Martin, D., C. R. Rioux, A. Villeneuve, J. Hamel, and B. R. Brodeur. 1998. Presented at the 11th International Pathogenic Neisseria Conference.
13. Moe, G. R., S. Tan, and D. M. Granoff. 1999. Differences in surface expression of NspA among Neisseria meningitidis group B strains. Infect. Immun. 67:5664-5675.
14. Moe, G. R., P. Zuno-Mitchell, S. N. Hammond, and D. M. Granoff. 2002. Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains. Infect. Immun. 70:6021-6031.
15. Morley, S. L., M. J. Cole, C. A. Ison, M. A. Camaraza, F. Sotolongo, N. Anwar, I. Cuevas, M. Carbonero, H. C. Campa, G. Sierra, and M. Levin. 2001. Immunogenicity of a serogroup B meningococcal vaccine against multiple Neisseria meningitidis strains in infants. Pediatr. Infect.. Dis. J. 20:1054-1061.
16. Morley, S. L., and A. J. Pollard. 2001. Vaccine prevention of meningococcal disease, coming soon? Vaccine 20:666-687.
17. O' Dwyer, C. A. 2003. Expression and vaccine formulation of heterologous antigens using commensal Neisseria. Ph.D. thesis. Imperial College, London, England.
18. Oliver, K. J., K. M. Reddin, P. Bracegirdle, M. J. Hudson, R. Borrow, I. M. Feavers, A. Robinson, K. Cartwright, and A. R. Gorringe. 2002. Neisseria lactamica protects against experimental meningococcal infection. Infect. Immun. 70:3621-3626.
19. Plante, M., N. Cadieux, C. R. Rioux, J. Hamel, B. R. Brodeur, and D. Martin. 1999. Antigenic and molecular conservation of the gonococcal NspA protein. Infect. Immun. 67:2855-2861.
20. Poolman, J. T., C. Feron, G. Dequesne, P. A. Denoel, S. Dessoy, K. K. Goraj, D. E. Janssens, S. Kummert, Y. Lobet, E. Mertens, D. Y. Monnom, P. Momin, N. Pepin, J. L. Ruelle, J. J. Thonnard, V. G. Verlant, P. Voet, and F. X. Berthet. 2002. Outer membrane vesicles and other options for a meningococcal B vaccine., p. 135-149. In C. Ferreiros, M. T. Criado, and J. Vazquez (ed.), Emerging strategies in the fight against meningitis: molecular and cellular aspects. Horizon Scientific Press, Wymondham, United Kingdom.
21. Rioux, S., D. Martin, H. W. Ackermann, J. Dumont, J. Hamel, and B. R. Brodeur. 2001. Localization of surface immunogenic protein on group B streptococcus. Infect. Immun. 69:5162-5165.
22. Rosenqvist, E., K. Bryn, K. Harbak, J. Hoist, E. A. Hoiby, P. Kristiansen, H. Lange, D. Martin, K. Moyner, E. Namork, K. Nord, L. M. Naess, A. G. Skryten, I. Aaberge, A. Aase, and H. Nokleby. 2002. Presented at the 13th International Pathogenic Neisseria Conference, Oslo, Norway.
23. Rosenqvist, E., E. A. Hoiby, E. Wedege, K. Bryn, J. Kolberg, A. Klem, E. Ronnild, G. Bjune, and H. Nokleby. 1995. Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine. Infect. Immun. 63:4642-4652.
24. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
25. Saunders, N. B., D. R. Shoemaker, B. L. Brandt, E. E. Moran, T. Larsen, and W. D. Zollinger. 1999. Immunogenicity of intranasally administered meningococcal native outer membrane vesicles in mice. Infect. Immun. 67:113-119.
26. Sierra, G. V., H. C. Campa, N. M. Varcacel, I. L. Garcia, P. L. Izquierdo, P. F. Sotolongo, G. V. Casanueva, C. O. Rico, C. R. Rodriguez, and M. H. Terry. 1991. Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba. NIPH Annu. 14:195-207.
27. Tappero, J. W., R. Lagos, A. M. Ballesteros, B. Plikaytis, D. Williams, J. Dykes, L. L. Gheesling, G. M. Carlone, E. A. Hoiby, J. Holst, H. Nokleby, E. Rosenqvist, G. Sierra, C. Campa, F. Sotolongo, J. Vega, J. Garcia, P. Herrera, J. T. Poolman, and B. A. Perkins. 1999. Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile. JAMA 281:1520-1527.
28. Tondella, M. L., T. Popovic, N. E. Rosenstein, D. B. Lake, G. M. Carlone, L. W. Mayer, and B. A. Perkins. 2000. Distribution of Neisseria meningitidis serogroup B serosubtypes and serotypes circulating in the United States. The Active Bacterial Core Surveillance Team. J. Clin. Microbiol. 38:3323-3328.
29. Webb, S. A., P. R. Langford, and J. S. Kroll. 2001. A promoter probe plasmid based on green fluorescent protein. A strategy for studying meningococcal gene expression. Methods Mol. Med. 67:663-678.
30. Wyle, F. A., M. S. Artenstein, B. L. Brandt, E. C. Trament, D. L. Kasper, P. L. Altieri, S. L. Herman, and J. P. Lowenthal. 1972. Immunologic response of man to group B meningococcal polysaccharide vaccines. J. Infect. Dis. 126:514-521.