Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients

Diabetic Medicine

Volumn 26, Issue 11, 2009, Pages 1120-1126

  Thomsen, N O B ^a   Englund, E ^a   Thrainsdottir, S ^b   Rosen I ^a   Dahlin, L B ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Carpal tunnel syndrome; Diabetes; Intra epidermal nerve fibre density; Protein gene product 9.5; Skin biopsy

Indexed keywords

GENE PRODUCT; HEMOGLOBIN A1C;

ARTICLE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE DURATION; FEMALE; GLABROUS SKIN; HUMAN; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROSCOPY; NERVE FIBER; NEUROPHYSIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL NEUROPATHY; PUNCH BIOPSY;

ADULT; AGED; CARPAL TUNNEL SYNDROME; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; EPIDERMIS; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; NEURAL CONDUCTION; REFERENCE VALUES; SENSORY THRESHOLDS; WRIST JOINT;

EID: 70350786424     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2009.02823.x     Document Type: Article

References (30)

1. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003 60 : 108 111.
2. Loseth S, Stalberg E, Jorde R, Mellgren SI. Early diabetic neuropathy: thermal thresholds and intraepidermal nerve fibre density in patients with normal nerve conduction studies. J Neurol 2008 255 : 1197 1202.
3. Nebuchennykh M, Loseth S, Jorde R, Mellgren SI. Idiopathic polyneuropathy and impaired glucose metabolism in a Norwegian patient series. Eur J Neurol 2008 15 : 810 816.
4. Malik RA, Tesfaye S, Newrick PG, Walker D, Rajbhandari SM, Siddique I et al. Sural nerve pathology in diabetic patients with minimal but progressive neuropathy. Diabetologia 2005 48 : 578 585.
5. Lauria G, Cornblath DR, Johansson O, McArthur JC, Mellgren SI, Nolano M et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005 12 : 747 758.
6. Liang HW, Hsieh ST, Cheng TJ, Du CL, Wang JD, Chen MF et al. Reduced epidermal nerve density among hand-transmitted vibration-exposed workers. J Occup Environ Med 2006 48 : 549 555.
7. Chien HF, Tseng TJ, Lin WM, Yang CC, Chang YC, Chen RC et al. Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta Neuropathol (Berl) 2001 102 : 455 461.
8. Kelly EJ, Terenghi G, Hazari A, Wiberg M. Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand. Br J Plast Surg 2005 58 : 774 779.
9. Nolano M, Provitera V, Crisci C, Stancanelli A, Wendelschafer-Crabb G, Kennedy WR et al. Quantification of myelinated endings and mechanoreceptors in human digital skin. Ann Neurol 2003 54 : 197 205.
10. Pittenger GL, Ray M, Burcus NI, McNulty P, Basta B, Vinik AI. Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care 2004 27 : 1974 1979.
11. Thomsen NO, Mojaddidi M, Malik RA, Dahlin LB. Biopsy of the posterior interosseous nerve: a low morbidity method for assessment of peripheral nerve disorders. Diabet Med 2009 26 : 100 104.
12. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006 29 : S43 S48.
13. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT et al. Distal symmetric polyneuropathy: a definition for clinical research. Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2005 64 : 199 207.
14. Tankisi H, Pugdahl K, Fuglsang-Frederiksen A, Johnsen B, de Carvalho M, Fawcett PR et al. Pathophysiology inferred from electrodiagnostic nerve tests and classification of polyneuropathies. Suggested guidelines. Clin Neurophysiol 2005 116 : 1571 1580.
15. Koskinen M, Hietaharju A, Kylaniemi M, Peltola J, Rantala I, Udd B et al. A quantitative method for the assessment of intraepidermal nerve fibers in small-fiber neuropathy. J Neurol 2005 252 : 789 794.
16. Loseth S, Lindal S, Stalberg E, Mellgren SI. Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy. Eur J Neurol 2006 13 : 105 111.
17. Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 1996 47 : 1042 1048.
18. Sorensen L, Molyneaux L, Yue DK. The relationship among pain, sensory loss, and small nerve fibers in diabetes. Diabetes Care 2006 29 : 883 887.
19. Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 2007 56 : 2148 2154.
20. Agardh CD, Rosen I, Schersten B. Improvement of peripheral nerve function after institution of insulin treatment in diabetes mellitus. A case-control study. Acta Med Scand 1983 213 : 283 287.
21. Goransson LG, Mellgren SI, Lindal S, Omdal R. The effect of age and gender on epidermal nerve fiber density. Neurology 2004 62 : 774 777.
22. McArthur JC, Stocks EA, Hauer P, Cornblath DR, Griffin JW. Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol 1998 55 : 1513 1520.
23. Jacobs JM, Love S. Qualitative and quantitative morphology of human sural nerve at different ages. Brain 1985 108 : 897 924.
24. Verdu E, Ceballos D, Vilches JJ, Navarro X. Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst 2000 5 : 191 208.
25. Pastore C, Izura V, Geijo-Barrientos E, Dominguez JR. A comparison of electrophysiological tests for the early diagnosis of diabetic neuropathy. Muscle Nerve 1999 22 : 1667 1673.
26. Shun CT, Chang YC, Wu HP, Hsieh SC, Lin WM, Lin YH et al. Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004 127 : 1593 1605.
27. Dyck PJ, Karnes JL, Daube J, O'Brien P, Service FJ. Clinical and neuropathological criteria for the diagnosis and staging of diabetic polyneuropathy. Brain 1985 108 : 861 880.
28. Dahlin LB, Shyu BC, Danielsen N, Andersson SA. Effects of nerve compression or ischaemia on conduction properties of myelinated and non-myelinated nerve fibres. An experimental study in the rabbit common peroneal nerve. Acta Physiol Scand 1989 136 : 97 105.
29. Granovsky Y, Matre D, Sokolik A, Lorenz J, Casey KL. Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis. Pain 2005 115 : 238 247.
30. Meh D, Denislic M. Quantitative assessment of thermal and pain sensitivity. J Neurol Sci 1994 127 : 164 169.