PCTK proteins: The forgotten brain kinases?

NeuroSignals

Volumn 17, Issue 4, 2009, Pages 288-297

  Cole, Adam R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Brain; Kinase; Neuron; PCTAIRE; PCTK; Phosphorylation

Indexed keywords

FLUOXETINE; PROTEIN PCTK1; PROTEIN PCTK2; PROTEIN PCTK3; PROTEIN PCTK3B; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VENLAFAXINE;

CELL CYCLE; DEPRESSION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; NERVE FIBER GROWTH; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ANIMALS; BRAIN; CELL CYCLE; HUMANS; NERVOUS SYSTEM DISEASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 70350782350     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000231895     Document Type: Review

References (37)

1. Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, et al: X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Hum Mol Genet 1996; 5: 391-401.
2. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, et al: A family of human cdc2-related protein kinases. EMBO J 1992; 11: 2909-2917.
3. Herskovits AZ, Davies P: Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. Gene 2004; 328: 59-67.
4. Besset V, Rhee K, Wolgemuth DJ: The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation. Cell Growth Differ 1999; 10: 173-181.
5. Liu Y, Cheng K, Gong K, Fu AK, Ip NY: Pctaire1 phosphorylates N-ethylmaleimidesensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. J Biol Chem 2006; 281: 9852-9858.
6. Hirose T, Tamaru T, Okumura N, Nagai K, Okada M: PCTAIRE 2, a Cdc2-related serine/ threonine kinase, is predominantly expressed in terminally differentiated neurons. Eur J Biochem 1997; 249: 481-488.
7. Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M: Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Eur J Biochem 2000; 267: 2113-2121.
8. Herskovits AZ, Davies P: The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiol Dis 2006; 23: 398-408.
9. Charrasse S, Carena I, Hagmann J, Woods-Cook K, Ferrari S: PCTAIRE-1: characterization, subcellular distribution, and cell cycle-dependent kinase activity. Cell Growth Differ 1999; 10: 611-620.
10. Palmer KJ, Konkel JE, Stephens DJ: PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J Cell Sci 2005; 118: 3839-3847.
11. Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F: Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins. Eur J Biochem 1998; 257: 112-120.
12. Le Bouffant F, Le Minter P, Traiffort E, Ruat M, Sladeczek F: Multiple subcellular localizations of PCTAIRE-1 in brain. Mol Cell Neurosci 2000; 16: 388-395.
13. Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T: Regulation of the CDKrelated protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. J Cell Sci 2002; 115: 3479-3490.
14. Malumbres M, Barbacid M: Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 2009; 9: 153-166.
15. Naumann U, Huang H, Wolburg H, Wischhusen J, Weit S, Ohgaki H, et al: PCTAIRE3: A putative mediator of growth arrest and death induced by CTS-1, a dominant-positive p53-derived synthetic tumor suppressor, in human malignant glioma cells. Cancer Gene Ther 2006; 13: 469-478.
16. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, et al: Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 2002; 13: 1977-2000.
17. Yamochi T, Nishimoto I, Okuda T, Matsuoka M: ik3-1/Cables is associated with Trap and Pctaire2. Biochem Biophys Res Commun 2001; 286: 1045-1050.
18. Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY: Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. J Biol Chem 2002; 277: 31988-31993.
19. Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, et al: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 1995; 376: 313-320.
20. McGrath CF, Pattabiraman N, Kellogg GE, Lemcke T, Kunick C, Sausville EA, et al: Homology model of the CDK1/cyclin B complex. J Biomol Struct Dyn 2005; 22: 493-502.
21. Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 1994; 371: 419-423.
22. Sutherland C, Cohen P: The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro. FEBS Lett 1994; 338: 37-42.
23. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789.
24. Frame S, Cohen P, Biondi RM: A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell 2001; 7: 1321-1327.
25. Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A: Structure and regulation of the CDK5-p25(nck5a) complex. Mol Cell 2001; 8: 657-669.
26. Wissing J, Jansch L, Nimtz M, Dieterich G, Hornberger R, Keri G, et al: Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics 2007; 6: 537-547.
27. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, et al: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 2008; 31: 438-448.
28. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, et al: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci USA 2008; 105: 10762-10767.
29. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007; 131: 1190-1203.
30. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006; 127: 635-648.
31. Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, et al: A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol 1996; 16: 6486-6493.
32. Tang X, Guilherme A, Chakladar A, Powelka AM, Konda S, Virbasius JV, et al: An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci USA 2006; 103: 2087-2092.
33. Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F: The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. Mol Gen Genet 1997; 254: 571-577.
34. Hosokawa M, Shoji M, Kitamura K, Tanaka T, Noce T, Chuma S, et al: Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/ TRAP: Domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol 2007; 301: 38-52.
35. Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, Lanier LM, et al: Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 2000; 26: 633-646.
36. Svenningsson P, Greengard P: p11 (S100A10) -an inducible adaptor protein that modulates neuronal functions. Curr Opin Pharmacol 2007; 7: 27-32.
37. Khawaja X, Xu J, Liang JJ, Barrett JE: Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: implications for depressive disorders and future therapies. J Neurosci Res 2004; 75: 451-460.