Autism: The Ups and Downs of Neuroligin

Biological Psychiatry

Volumn 66, Issue 10, 2009, Pages 904-905

  Geschwind, Daniel H ^a  

^a Department of Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; NEUROLIGIN; NEUROLIGIN 3; NEUROLIGIN 4; NEUROLIGIN 4X; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTISM; CHROMOSOME DISORDER; CHROMOSOME SUBSTITUTION; CHROMOSOME VARIANT; COHORT ANALYSIS; COPY NUMBER VARIATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOME ANALYSIS; HAPLOTYPE; HUMAN; IDIOPATHIC DISEASE; IN VITRO STUDY; LYMPHOBLAST; MENTAL DEFICIENCY; MICROARRAY ANALYSIS; PATHOGENICITY; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; STOP CODON; TERATOLOGY; X CHROMOSOME;

EID: 70350774308     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.09.022     Document Type: Note

References (14)

1. Gillberg C., and Coleman M. The Biology of the Autistic Syndromes (2000), Mac Keith Press, London 340
2. Wang K., Zhang H., Ma D., Bucan M., Glessner J.T., Abrahams B.S., et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 459 (2009) 528-533
3. Strom S.P., Stone J.L., Ten Bosch J.R., Merriman B., Cantor R.M., Geschwind D.H., and Nelson S.F. High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. [published online ahead of print May 19]. Mol Psychiatry (2009)
4. Alarcón M., Abrahams B.S., Stone J.L., Duvall J.A., Perederiy J.V., Bomar J.M., et al. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet 82 (2008) 150-159
5. Sebat J., Lakshmi B., Malhotra D., Troge J., Lese-Martin C., Walsh T., et al. Strong association of de novo copy number mutations with autism. Science 316 (2007) 445-449
6. Bucan M., Abrahams B.S., Wang K., Glessner J.T., Herman E.I., Sonnenblick L.I., et al. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet 5 (2009) e1000536
7. Cook Jr. E.H., and Scherer S.W. Copy-number variations associated with neuropsychiatric conditions. Nature 455 (2008) 919-923
8. Cook Jr. E.H., Lindgren V., Leventhal B.L., Courchesne R., Lincoln A., Shulman C., et al. Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. Am J Hum Genet 60 (1997) 928-934
9. Abrahams B.S., and Geschwind D.H. Advances in autism genetics: On the threshold of a new neurobiology. Nat Rev Genet 9 (2008) 341-355
10. Weiss L.A., Shen Y., Korn J.M., Arking D.E., Miller D.T., Fossdal R., et al. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 358 (2008) 667-675
11. Jamain S., Quach H., Betancur C., Råstam M., Colineaux C., Gillberg I.C., et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 34 (2003) 27-29
12. Laumonnier F., Bonnet-Brilhault F., Gomot M., Blanc R., David A., Moizard M.P., et al. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am J Hum Genet 74 (2004) 552-557
13. Daoud H., Bonnet-Brilhault F., Védrine S., Demattéi M.V., Vourc'h P., Bayou N., et al. Autism and nonsyndromic mental retardation associated with a de novo mutation in the NLGN4X gene promoter causing an increased expression level. Biol Psychiatry 66 (2009) 906-910
14. Bakkaloglu B., O'Roak B.J., Louvi A., Gupta A.R., Abelson J.F., Morgan T.M., et al. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet 82 (2008) 165-173