Formation of nanoliter droplets in a confined microfluidic T-shaped junction: Formation time and droplet volume

Current Nanoscience

Volumn 5, Issue 4, 2009, Pages 519-526

  Zhang, Yuxiang ^a   Fan, Jing ^a   Wang, Liqiu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Droplet formation time; Droplet volume; Microchannel; Nanoliter droplet; T shaped junctions

Indexed keywords

CAPILLARY NUMBERS; CONTINUOUS PHASE; DISPERSE PHASE; DROPLET FORMATION; DROPLET FORMATION PROCESS; DROPLET FORMATION TIME; DROPLET VOLUME; EMPIRICAL EQUATIONS; EXPERIMENTAL VISUALIZATION; FLOWRATE RATIO; INTERFACIAL TENSIONS; MEAN VELOCITIES; NANOLITER DROPLET; NANOLITERS; SIMPLE MODEL; T-SHAPED JUNCTIONS;

CAPILLARITY; MICROCHANNELS; PHASE INTERFACES;

DROP FORMATION;

NANOMATERIAL;

ARTICLE; CAPILLARY FLOW; FLOW KINETICS; MATHEMATICAL ANALYSIS; MICROFLUIDICS; NANOENGINEERING; PRIORITY JOURNAL; TENSION; VISCOSITY;

EID: 70350755598     PISSN: 15734137     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341309789378023     Document Type: Article

References (33)

1. Clausell-Tormos, J.; Lieber, D.; Baret, J.C.; El-Harrak, A.; Miller, O.J.; Frenz, L.; Blouwolff, J.; Humphry, K.J.; Koster, S.; Duan, H.; Holtze, C.; Weitz, D.A.; Griffiths, A.D.; Merten, C.A. Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms. Chem. Biol., 2008, 15(5), 427-437.
2. Henares, T.G.; Mizutani, F.; Sekizawa, R.; Hisamoto, H. Single-drop analysis of various proteases in a cancer cell lysate using a capillary-assembled microchip. Anal. Bioanal. Chem., 2008, 391(7), 2507-2512.
3. Li, S.W.; Xu, H.H.; Wang, Y.J.; Luo, G.S. Controllable preparation of nanoparticles by drops and plugs flow in a microchannel device. Langmuir, 2008, 24(8), 4194-4199.
4. Song, Y.J.; Hormes, J.; Kumar, C. Microfluidic synthesis of nanomaterials. Small, 2008, 4(6), 698-711.
5. Chan, E.M.; Alivisatos, A.P.; Mathies, R.A. High-temperature microfluidic synthesis of cdse nanocrystals in nanoliter droplets. J. Am. Chem. Soc., 2005, 127(40), 13854-13861.
6. Hung, L.H.; Choi, K.M.; Tseng, W.Y.; Tan, Y.C.; Shea, K.J.; Lee, A.P. Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for cds nanoparticle synthesis. Lab Chip, 2006, 6(2), 174-178.
7. Shestopalov, I.; Tice, J.D.; Ismagilov, R.F. Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system. Lab Chip, 2004, 4(4), 316-321.
8. Song, H.; Chen, D.L.; Ismagilov, R.F. Reactions in droplets in microflulidic channels. Angew. Chem. Int. Ed., 2006, 45(44), 7336-7356.
9. Kobayashi, I.; Nakajima, M. Microchannel emulsification technology: Formulation and application of monodisperse emulsions. J. Jpn. Soc. Food Sci. Technol. Nippon Shokuhin Kagaku Kogaku Kaishi, 2006, 53(6), 317-326.
10. Kawakatsu, T.; Komori, H.; Nakajima, M.; Kikuchi, Y.; Yonemoto, T. Production of monodispersed oil-in-water emulsion using crossflow-type silicon microchannel plate. J. Chem. Eng. Jpn., 1999, 32(2), 241-244. (Pubitemid 29384739)
11. Kobayashi, I.; Lou, X.F.; Mukataka, S.; Nakajima, M. Preparation of monodisperse water-in-oil-in-water emulsions using microfluidization and straight-through microchannel emulsification. J. Am. Oil Chem. Soc., 2005, 82(1), 65-71. (Pubitemid 43026198)
12. Saito, M.; Yin, L.J.; Kobayashi, I.; Nakajima, M. Preparation characteristics of monodispersed oil-in-water emulsions with large particles stabilized by proteins in straight-through microchannel emulsification. Food Hydrocolloids, 2005, 19(4), 745-751. (Pubitemid 40292929)
13. Xu, Q.Y.; Nakajima, M.; Binks, B.P. Preparation of particle-stabilized oil-in-water emulsions with the microchannel emulsification method. Colloids Surf. A, 2005, 262(1-3), 94-100. (Pubitemid 40965721)
14. Anna, S.L.; Bontoux, N.; Stone, H.A. Formation of dispersions using "Flow focusing" In microchannels. Appl. Phys. Lett., 2003, 82(3), 364-366.
15. Ganan-Calvo, A.M. Perfectly monodisperse microbubbling by capillary flow focusing: An alternate physical description and universal scaling. Phys. Rev. E, 2004, 69(2), 027301.
16. Ganan-Calvo, A.M.; Gordillo, J.M. Perfectly monodisperse microbubbling by capillary flow focusing. Phys. Rev. Lett., 2001, 87(27), 274501.
17. Garstecki, P.; Gitlin, I.; DiLuzio, W.; Whitesides, G.M.; Kumacheva, E.; Stone, H.A. Formation of monodisperse bubbles in a microfluidic flow-focusing device. Appl. Phys. Lett., 2004, 85(13), 2649-2651.
18. Garstecki, P.; Stone, H.A.; Whitesides, G.M. Mechanism for flow-rate controlled breakup in confined geometries: a route to monodisperse emulsions. Phys. Rev. Lett., 2005, 94(16), 164501.
19. Chu, L.Y.; Utada, A.S.; Shah, R.K.; Kim, J.W.; Weitz, D.A. Controllable monodisperse multiple emulsions. Angew. Chem. Int. Ed., 2007, 46(47), 8970-8974.
20. Shah, R.K.; Shum, H.C.; Rowat, A.C.; Lee, D.; Agresti, J.J.; Utada, A.S.; Chu, L.Y.; Kim, J.W.; Fernandez-Nieves, A.; Martinez, C.J.; Weitz, D.A. Designer emulsions using microfluidics. Mater. Today, 2008, 11(4), 18-27.
21. Utada, A.S.; Lorenceau, E.; Link, D.R.; Kaplan, P.D.; Stone, H.A.; Weitz, D.A. Monodisperse double emulsions generated from a microcapillary device. Science, 2005, 308(5721), 537-541. (Pubitemid 40570581)
22. Xu, J.H.; Li, S.W.; Tan, J.; Wang, Y.J.; Luo, G.S. Controllable preparation of monodisperse o/w and w/o emulsions in the same microfluidic device. Langmuir, 2006, 22(19), 7943-7946.
23. van der Graaf, S.; Steegmans, M.L.J.; van der Sman, R.G.M.; Schroen, C.; Boom, R.M. Droplet formation in a t-shaped microchannel junction: A model system for membrane emulsification. Colloids Surf. A, 2005, 266(1-3), 106-116.
24. Thorsen, T.; Roberts, R.W.; Arnold, F.H.; Quake, S.R. Dynamic pattern formation in a vesicle-generating microfluidic device. Phys. Rev. Lett., 2001, 86(18), 4163-4166. (Pubitemid 32443957)
25. Husny, J.; Cooper-White, J.J. The effect of elasticity on drop creation in t-shaped microchannels. J. Non-Newtonian Fluid Mech., 2006, 137(1-3), 121-136.
26. Xu, J.H.; Luo, G.S.; Chen, G.G.; Wang, J.D. Experimental and theoretical approaches on droplet formation from a micrometer screen hole. J. Membr. Sci., 2005, 266(1-2), 121-131.
27. Garstecki, P.; Fuerstman, M.J.; Stone, H.A.; Whitesides, G.M. Formation of droplets and bubbles in a microfluidic t-junction - scaling and mechanism of break-up. Lab. Chip, 2006, 6(3), 437-446.
28. Xu, J.H.; Li, S.W.; Tan, J.; Wang, Y.J.; Luo, G.S. Preparation of highly monodisperse droplet in a t-junction microfluidic device. AIChEJ, 2006, 52(9), 3005-3010. (Pubitemid 44368684)
29. Christopher, G.F.; Anna, S.L. Microfluidic methods for generating continuous droplet streams. J. Phys. D Appl. Phys., 2007, 40(19), R319-R336.
30. De Luca, G.; Drioli, E. Force balance conditions for droplet formation in cross-flow membrane emulsifications. J. Colloid Interface Sci., 2006, 294(2), 436-448. (Pubitemid 41676810)
31. Peng, S.J.; Williams, R.A. Controlled production of emulsions using a crossflow membrane. Part Part. Syst. Char., 1998, 15(1), 21-25.
32. De Menech, M.; Garstecki, P.; Jousse, F.; Stone, H.A. Transition from squeezing to dripping in a microfluidic t-shaped junction. J. Fluid Mech., 2008, 595, 141-161.
33. van der Graaf, S.; Nisisako, T.; Schroen, C.; van der Sman, R.G.M.; Boom, R.M. Lattice boltzmann simulations of droplet formation in a t-shaped microchannel. Langmuir, 2006, 22(9), 4144-4152.