Effect of propofol on the levels of neurotransmitters in normal human brain: A magnetic resonance spectroscopy study

Neuroscience Letters

Volumn 467, Issue 3, 2009, Pages 247-251

  Zhang, Hui ^a   Wang, Wei ^a   Gao, Wei ^a   Ge, Yali ^b   Zhang, Jinsong ^b   Wu, Shengxi ^a   Xu, Lixian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anesthesia; Human brain; Magnetic resonance spectroscopy; Neurotransmitters; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID; CHOLINE; CREATINE; GLUTAMIC ACID; N ACETYLASPARTIC ACID; NEUROTRANSMITTER; PROPOFOL;

ADULT; ALERTNESS; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; INFUSION PUMP; MALE; NEUROTRANSMITTER RELEASE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBSERVER ASSESSMENT OF ALERTNESS SEDATION SCALE; PRIORITY JOURNAL; RATING SCALE; THALAMUS; UNCONSCIOUSNESS; UPREGULATION; WAKEFULNESS;

ACETYLCHOLINE; ADULT; ANESTHETICS, INTRAVENOUS; ASPARTIC ACID; BRAIN; BRAIN CHEMISTRY; CHOLINE; CONSCIOUSNESS; CREATINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEURAL INHIBITION; NEUROTRANSMITTER AGENTS; PROPOFOL; YOUNG ADULT;

EID: 70350752178     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.10.052     Document Type: Article

References (23)

1. Baars J.H., von Dincklage F., Reiche J., and Rehberg B. Propofol increases presynaptic inhibition of IA afferents in the intact human spinal cord. Anesthesiology 104 (2006) 798-804
2. Block W., Traber F., Flacke S., Jessen F., Pohl C., and Schild H. In vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration. Amino Acids 23 (2002) 317-323
3. Buggy D.J., Nicol B., Rowbotham D.J., and Lambert D.G. Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition. Anesthesiology 92 (2000) 1067-1073
4. Heerschap A., Kok R.D., and van den Berg P.P. Antenatal proton MR spectroscopy of the human brain in vivo. Childs Nerv. Syst. 19 (2003) 418-421
5. Hoymork S.C., and Raeder J. Why do women wake up faster than men from propofol anaesthesia?. Br. J. Anaesth. 95 (2005) 627-633
6. 31P magnetic resonance study. J. Neurochem. 90 (2004) 1321-1330
7. Inagawa G., Sato K., Kikuchi T., Nishihama M., Shioda M., Koyama Y., Yamada Y., and Andoh T. Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo. Br. J. Anaesth. 93 (2004) 737-739
8. Jin Y.H., Zhang Z., Mendelowitz D., and Andresen M.C. Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons. Brain Res. 1286 (2009) 75-83
9. Lingamaneni R., Birch M.L., and Hemmings Jr. H.C. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology 95 (2001) 1460-1466
10. Liu S.H., Wei W., Ding G.N., Ke J.D., Hong F.X., and Tian M. Relationship between depth of anesthesia and effect-site concentration of propofol during induction with the target-controlled infusion technique in elderly patients. Chin. Med. J. (Engl.) 122 (2009) 935-940
11. Lu C.W., Lin T.Y., Chiang H.S., and Wang S.J. Facilitation of glutamate release from rat cerebral cortex nerve terminal by subanesthetic concentration propofol. Synapse 63 (2009) 773-781
12. Marik P.E. Propofol: therapeutic indications and side-effects. Curr. Pharm. Des. 10 (2004) 3639-3649
13. McDougall S.J., Bailey T.W., Mendelowitz D., and Andresen M.C. Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS). Neuropharmacology 54 (2008) 552-563
14. Ogawa K., Uema T., Motohashi N., Nishikawa M., Takano H., Hiroki M., Imabayashi E., Ohnishi T., Inoue T., Takayama Y., Takeda M., Matsuda H., Andoh T., and Yamada Y. Neural mechanism of propofol anesthesia in severe depression: a positron emission tomographic study. Anesthesiology 98 (2003) 1101-1111
15. Pocock G., and Richards C.D. Excitatory and inhibitory synaptic mechanisms in anaesthesia. Br. J. Anaesth. 71 (1993) 134-147
16. Potter L.T., and Murphy W. Electrophoresis of acetylcholine, choline and related compounds. Biochem. Pharmacol. 16 (1967) 1386-1388
17. Shimizu M., Yamakura T., Tobita T., Okamoto M., Ataka T., Fujihara H., Taga K., Shimoji K., and Baba H. Propofol enhances GABA(A) receptor-mediated presynaptic inhibition in human spinal cord. Neuroreport 13 (2002) 357-360
18. Vanlersberghe C., and Camu F. Propofol. Handb. Exp. Pharmacol. (2008) 227-252
19. Wang X. Propofol and isoflurane enhancement of tonic gamma-aminobutyric acid type a current in cardiac vagal neurons in the nucleus ambiguous. Anesth. Analg. 108 (2009) 142-148
20. Wei H., Xiong W., Yang S., Zhou Q., Liang C., Zeng B.X., and Xu L. Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats. Neurosci. Lett. 324 (2002) 181-184
21. Westphalen R.I., and Hemmings Jr. H.C. Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals. Anesthesiology 98 (2003) 364-372
22. Westphalen R.I., and Hemmings Jr. H.C. Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release. J. Pharmacol. Exp. Ther. 316 (2006) 208-215
23. Ying S.W., and Goldstein P.A. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol. Pain 1 (2005) 2