Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis

Journal of Vascular Surgery

Volumn 50, Issue 5, 2009, Pages 1127-1134

  Humphries, Julia ^a   Gossage, James A ^a   Modarai, Bijan ^a   Burnand, Kevin G ^a   Sisson, Thomas H ^b   Murdoch, Colin ^a   Smith, Alberto ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOCYTE ANTIGEN; RANTES; UROKINASE; UROKINASE RECEPTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL MIGRATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; FIBRINOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; THROMBUS; UPREGULATION; VEIN THROMBOSIS;

ADENOVIRIDAE; ANIMALS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; FIBRINOLYSIS; FLUORESCENT DYES; GENE THERAPY; GENETIC VECTORS; HLA ANTIGENS; HUMANS; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; MICE, SCID; ORGANIC CHEMICALS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; STAINING AND LABELING; TIME FACTORS; TRANSDUCTION, GENETIC; UP-REGULATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VENOUS THROMBOSIS;

EID: 70350751563     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.06.047     Document Type: Article

References (40)

1. Masuda E.M., Kessler D.M., Kistner R.L., Eklof B., and Sato D.T. The natural history of calf vein thrombosis: lysis of thrombi and development of reflux. J Vasc Surg 28 (1998) 67-73
2. Meissner M.H., Caps M.T., Zierler B.K., Polissar N., Bergelin R.O., Manzo R.A., et al. Determinants of chronic venous disease after acute deep venous thrombosis. J Vasc Surg 28 (1998) 826-833
3. Rectenwald J.E., and Wakefield T.W. The treatment of deep venous thrombosis, including the newer agents. Dis Mon 51 (2005) 104-111
4. Mewissen M.W. Catheter-directed thrombolysis for lower extremity deep vein thrombosis. Tech Vasc Interv Radiol 4 (2001) 111-114
5. Cox J.S.T. The maturation and canalisation of thrombi. Surg Gyn Obstet 116 (1963) 593-599
6. Northeast A.D., Soo K.S., Bobrow L.G., Gaffney P.J., and Burnand K.G. The tissue plasminogen activator and urokinase response in vivo during natural resolution of venous thrombus. J Vasc Surg 22 (1995) 573-579
7. McGuinness C.L., Humphries J., Waltham M., Burnand K.G., Collins M., and Smith A. Recruitment of labelled monocytes by experimental venous thrombi. Thromb Haemost 85 (2001) 1018-1024
8. Sappino A.P., Huarte J., Belin D., and Vassalli J.D. Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol 109 (1989) 2471-2479
9. Wohlwend A., Belin D., and Vassalli J.D. Plasminogen activator-specific inhibitors produced by human monocytes/macrophages. J Exp Med 165 (1987) 320-339
10. Singh I., Burnand K.G., Collins M., Luttun A., Collen D., Boelhouwer B., et al. Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells. Circulation 107 (2003) 869-875
11. Gossage J.A., Humphries J., Modarai B., Burnand K.G., and Smith A. Adenoviral urokinase-type plasminogen activator (uPA) gene transfer enhances venous thrombus resolution. J Vasc Surg 44 (2006) 1085-1090
12. Parker A.L., Nicklin S.A., and Baker A.H. Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications. Curr Opin Mol Ther 10 (2008) 439-448
13. Hattori N., Sisson T.H., Xu Y., Desai T.J., and Simon R.H. Participation of urokinase-type plasminogen activator receptor in the clearance of fibrin from the lung. Am J Physiol 277 (1999) L573-L579
14. Graziani-Bowering G.M., Graham J.M., and Filion L.G. A quick, easy and inexpensive method for the isolation of human peripheral blood monocytes. J Immunol Methods 207 (1997) 157-168
15. Foxwell B., Browne K., Bondeson J., Clarke C., de Martin R., Brennan F., et al. Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc Natl Acad Sci U S A 95 (1998) 8211-8215
16. Millar W.T., and Smith J.F. Comparative study of different urokinase preparations. Thromb Res 30 (1983) 425-429
17. Declerck P.J., Van Keer L., Verstreken M., and Collen D. An enzyme-linked immunosorbent assay for urokinase-type plasminogen activator (u-PA) and mutants and chimeras containing the serine protease domain of u-PA. Thromb Haemost 67 (1992) 95-100
18. Ngo T.H., and Declerck P.J. Immunological quantitation of rabbit plasminogen activator inhibitor-1 in biological samples: evidence that rabbit platelets do not contain PAI-1. Thromb Haemost 82 (1999) 1510-1515
19. Humphries J., Burnand K.G., Cunningham P., Brock A., Westwood N., and Smith A. Identification of potentially effective antisense oligodeoxyribonucleotide (ODN) sequences for inhibiting plasminogen activator inhibitor-2 (PAI-2) production by monocytes. Thromb Haemost 88 (2002) 131-136
20. Ellingsen T., Storgaard M., Moller B.K., Buus A., Andersen P.L., Obel N., et al. Migration of mononuclear cells in the modified Boyden chamber as evaluated by DNA quantification and flow cytometry. Scand J Immunol 52 (2000) 257-263
21. Waltham M., Burnand K.G., Collins M., McGuinness C.L., Singh I., and Smith A. Vascular endothelial growth factor enhances venous thrombus recanalisation and organisation. Thromb Haemost 89 (2003) 169-176
22. Horan P.K., Meryle J., Melnicoff M.J., Jensen B.D., and Slezak S. Fluorescent cell labelling for in vivo and in vitro cell tracking. Methods Cell Biol 42 (1990) 469-490
23. Modarai B., Humphries J., Gossage J.A., Waltham M., Burnand K.G., Kanaganayagam G.S., et al. Adenovirus-mediated VEGF gene therapy enhances venous thrombus recanalization and resolution. Arterioscler Thromb Vasc Biol 28 (2008) 1753-1759
24. Cunningham O., Andolfo A., Santovito M.L., Iuzzolino L., Blasi F., and Sidenius N. Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions. EMBO J 22 (2003) 5994-6003
25. Nykjaer A., Conese M., Christensen E.I., Olson D., Cremona O., Gliemann J., et al. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 16 (1997) 2610-2620
26. Schleef R.R., Olman M.A., Miles L.A., and Chuang J.L. Modulating the fibrinolytic system of peripheral blood mononuclear cells with adenovirus. Hum Gene Ther 12 (2001) 439-445
27. Higginbotham J.N., Seth P., Blaese R.M., and Ramsey W.J. The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid. Hum Gene Ther 13 (2002) 129-141
28. Varma M.R., Varga A.J., Knipp B.S., Sukheepod P., Upchurch G.R., Kunkel S.L., et al. Neutropenia impairs venous thrombosis resolution in the rat. J Vasc Surg 38 (2003) 1090-1098
29. Fontaine V., Jacob M.P., Houard X., Rossignol P., Plissonnier D., Angles-Cano E., et al. Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. Am J Pathol 161 (2002) 1701-1710
30. Moir E., Robbie L.A., Bennett B., and Booth N.A. Polymorphonuclear leucocytes have two opposing roles in fibrinolysis. Thromb Haemost 87 (2002) 1006-1010
31. Ali T., Humphries J., Burnand K., Sawyer B., Bursill C., Channon K., et al. Monocyte recruitment in venous thrombus resolution. J Vasc Surg 43 (2006) 601-608
32. Humphries J., McGuinness C.L., Smith A., Waltham M., Poston R., and Burnand K.G. Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi. J Vasc Surg 30 (1999) 894-899
33. Gyetko M.R., Todd III R.F., Wilkinson C.C., and Sitrin R.G. The urokinase receptor is required for human monocyte chemotaxis in vitro. J Clin Invest 93 (1994) 1380-1387
34. Blasi F. Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system. Thromb Haemost 82 (1999) 298-304
35. Myohanen H., and Vaheri A. Regulation and interactions in the activation of cell-associated plasminogen. Cell Mol Life Sci 61 (2004) 2840-2858
36. Andreesen R., Scheibenbogen C., Brugger W., Krause S., Meerpohl H.G., Leser H.G., et al. Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy. Cancer Res 50 (1990) 7450-7456
37. Pearce O.M., Fisher K.D., Humphries J., Seymour L.W., Smith A., and Davis B.G. Glycoviruses: chemical glycosylation retargets adenoviral gene transfer. Angew Chem Int Ed Engl 44 (2005) 1057-1061
38. Cozen A.E., Moriwaki H., Kremen M., DeYoung M.B., Dichek H.L., Slezicki K.I., et al. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109 (2004) 2129-2135
39. Gordon S. Macrophage heterogeneity and tissue lipids. J Clin Invest 117 (2007) 89-93
40. Martinez F.O., Gordon S., Locati M., and Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 177 (2006) 7303-7311