C-reactive protein, severity of pneumonia and mortality in elderly, hospitalised patients with community-acquired pneumonia

Age and Ageing

Volumn 38, Issue 6, 2009, Pages 693-697

  Thiem, Ulrich ^a,b   Niklaus, David ^a   Sehlhoff, Bettina ^a   Stückle, Christoph ^a   Heppner, Hans Jürgen ^c   Endres, Heinz Gerd ^b   Pientka, Ludger ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

C reactive protein; Community acquired pneumonia; CURB score; Elderly; Mortality

Indexed keywords

C REACTIVE PROTEIN;

AGED; AGED HOSPITAL PATIENT; ARTICLE; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NURSING HOME PATIENT; PNEUMONIA SEVERITY INDEX; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD PRESSURE; C-REACTIVE PROTEIN; COMMUNITY-ACQUIRED INFECTIONS; CONFUSION; FEMALE; GERMANY; HOSPITALIZATION; HUMANS; INTENSIVE CARE UNITS; LEUKOCYTE COUNT; MALE; PNEUMONIA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RESPIRATION; SEVERITY OF ILLNESS INDEX; UREA;

EID: 70350697886     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afp164     Document Type: Article

References (29)

1. Fine MJ, Auble TE, Yealy DM et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997; 336: 243-50.
2. Ewig S, Torres A, Woodhead M. Assessment of pneumonia severity: A European perspective. Eur Respir J 2006; 27: 6-8.
3. Lim WS, Van Der Eerden MM, Laing R et al. Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study. Thorax 2003; 58: 377-82.
4. Naito T, Suda T, Yasuda K et al. A validation and potential modification of the pneumonia severity index in elderly patients with community-acquired pneumonia. J Am Geriatr Soc 2006; 54: 1212-9.
5. Mody L, Sun R, Bradley S. Community-acquired pneumonia in older veterans: Does the pneumonia prognosis index help? J Am Geriatr Soc 2002; 50: 434-8.
6. Buising KL, Thursky KA, Black JF et al. A prospective comparison of severity scores for identifying patients with severe community acquired pneumonia: Reconsidering what is meant by severe pneumonia. Thorax 2006; 61: 419-24.
7. Capelastegui A, Espana PP, Quintana JM et al. Validation of a predictive rule for the management of community-acquired pneumonia. Eur Respir J 2006; 27: 151-7.
8. Ewig S, de Roux A, Bauer T et al. Validation of predictive rules and indices of severity for community acquired pneumonia. Thorax 2004; 59: 421-7.
9. Aujesky D, Auble TE, Yealy DM et al. Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia. Am J Med 2005; 118: 384-92.
10. Myint PK, Kamath AV, Vowler SL et al. The CURB (confusion, urea, respiratory rate and blood pressure) criteria in community-acquired pneumonia (CAP) in hospitalised elderly patients aged 65 years and over: a prospective observational cohort study. Age Ageing 2005; 34: 75-7.
11. Committee BTSPG. BTS Guideline for the Management of Community Acquired Pneumonia in Adults - Update 2004. http://www.brit-thoracic.org.uk 2004; (29 July 2008 date last accessed).
12. Woodhead M, Blasi F, Ewig S et al. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J 2005; 26: 1138-80.
13. Mandell LA, Wunderink R, Anzueto A et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44: S27-72.
14. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Med 2008; 121: 219-25.
15. Kruger S, Ewig S, Marre R et al. Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. Eur Respir J 2008; 31: 349-55.
16. Muller B, Suess E, Schuetz P et al. Circulating levels of pro-atrial natriuretic peptide in lower respiratory tract infections. J Intern Med 2006; 260: 568-76.
17. Schaaf B, Kruse J, Rupp J et al. Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia. Eur Respir J 2007; 30: 517-24.
18. Almirall J, Bolibar I, Toran P et al. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest 2004; 125: 1335-42.
19. Brunkhorst FM, Al-Nawas B, Krummenauer F et al. Procalcitonin, C-reactive protein and APACHE II score for risk evaluation in patients with severe pneumonia. Clin Microbiol Infect 2002; 8: 93-100.
20. Hansson LO, Hedlund JU, Ortqvist AB. Sequential changes of inflammatory and nutritional markers in patients with community-acquired pneumonia. Scand J Clin Lab Invest 1997; 57: 111-8.
21. Hedlund J, Hansson LO. Procalcitonin and C-reactive protein levels in community-acquired pneumonia: Correlation with etiology and prognosis. Infection 2000; 28: 68-73.
22. Muller B, Harbarth S, Stolz D et al. Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia. BMC Infect Dis 2007; 7: 10.
23. Ortqvist A, Hedlund J, Wretlind B et al. Diagnostic and prognostic value of interleukin-6 and C-reactive protein in community-acquired pneumonia. Scand J Infect Dis 1995; 27: 457-62.
24. Smith RP, Lipworth BJ. C-reactive protein in simple community-acquired pneumonia. Chest 1995; 107: 1028-31.
25. Smith RP, Lipworth BJ, Cree IA et al. C-reactive protein. A clinical marker in community-acquired pneumonia. Chest 1995; 108: 1288-91.
26. Barlow G, Nathwani D, Davey P. The CURB65 pneumonia severity score outperforms generic sepsis and early warning scores in predicting mortality in community-acquired pneumonia. Thorax 2007; 62: 253-9.
27. Kamath AV, Myint PK, Vowler SL et al. Is it time to rethink the urea criterion in CURB-65? Eur Respir J 2006; 27: 1321-2.
28. Myint PK, Kamath AV, Vowler SL et al. Severity assessment criteria recommended by the British Thoracic Society (BTS) for community-acquired pneumonia (CAP) and older patients. Should SOAR (systolic blood pressure, oxygenation, age and respiratory rate) criteria be used in older people? A compilation study of two prospective cohorts. Age Ageing 2006; 35: 286-91.
29. Aujesky D, Stone RA, Obrosky DS et al. Using randomized controlled trial data, the agreement between retrospectively and prospectively collected data comprising the pneumonia severity index was substantial. J Clin Epidemiol 2005; 58: 357-63.