A tunable continuous wave (CW) and short-pulse optical source for THz brain imaging applications

Measurement Science and Technology

Volumn 20, Issue 10, 2009, Pages

  Bakopoulos, P ^a   Karanasiou, I ^a   Pleros, N ^b   Zakynthinos, P ^a   Uzunoglu, N ^a   Avramopoulos, H ^a  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Brain imaging; Difference frequency generation; Supercontinuum generation; THz imaging

Indexed keywords

BRAIN MAPPING; FABRY-PEROT INTERFEROMETERS; IMAGING TECHNIQUES; NEUROIMAGING; NONLINEAR OPTICS; OPTICAL FIBERS; OPTICAL FREQUENCY CONVERSION; TERAHERTZ WAVES;

BRAIN IMAGING; BRAIN IMAGING TECHNIQUES; DIFFERENCE-FREQUENCY GENERATION; FIBER FABRY-PEROT FILTER; FREQUENCY TUNABILITY; NON-LINEAR OPTICAL FIBERS; OPTICAL WAVELENGTH; THZ IMAGING;

SUPERCONTINUUM GENERATION;

EID: 70350697844     PISSN: 09570233     EISSN: 13616501     Source Type: Journal    
DOI: 10.1088/0957-0233/20/10/104001     Document Type: Article

References (32)

1. Doria A et al 2004 THz radiation studies on biological systems at the ENEA FEL facility Infrared Phys. Technol. 45 339
2. Pickwell E et al 2004 Simulation of terahertz pulse propagation in biological systems Appl. Phys. Lett. 84 2190
3. Globus T et al 2003 Sub-millimetre wave absorption spectra of artificial RNA molecules J. Phys. D: Appl. Phys. 36 1314
4. Woolard D L et al 2002 Submillimeter-wave phonon modes in DNA macromolecules Phys. Rev. E 65 051903
5. Whitmire S E et al 2003 Protein flexibility and conformational state: a comparison of collective vibrational modes of wild-type and D96N bacteriorhodopsin Biophys. J. 85 1269
6. Woodward R M et al 2003 Terahertz pulsed imaging of skin cancer in the time and frequency domain J. Biol. Phys. 29 257
7. Fitzgerald A J et al 2003 Catalogue of human tissue optical properties at terahertz frequencies J. Biol. Phys. 129 123-8
8. Cole B E, Woodward R, Crawley D, Wallace V P, Arnone D D and Pepper M 2001 Terahertz imaging and spectroscopy of human skin, in vivo Proc. SPIE 4276 1-10
9. Woodward R M, Wallace V P, Cole B, Pye R J, Arnone D, Linfield E H and Pepper M 2002 Terahertz pulse imaging in reflection geometry of skin tissue using time domain analysis techniques Proc. SPIE 4625 160-9 (Pubitemid 35220557)
10. Brown E R 2007 THz photomixing Proc. Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (Lake Buena Vista, FL, 2007) p 790
11. Friedrich C S et al 2008 New two-color laser concepts for THz generation J. Sel. Top. Quantum Electron. 14 270-6
12. Yang T, Chan K T, Chen K J, Dong X Y and Tam H Y 2007 Generation of continuous THz wave by a compact dual-frequency semiconductor laser at room temperature Proc. Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (Lake Buena Vista, FL, 2007) p 866
13. Pelusi M D, Liu H F, Novak D and Ogawa Y 1997 THz optical beat frequency generation from a single mode locked semiconductor laser Appl. Phys. Lett. 71 449
14. Bakopoulos P, Karanasiou I, Zakynthinos P, Pleros N, Avramopoulos H and Uzunoglu N 2008 Towards brain imaging using THz technology IEEE Int. Workshop on Imaging Systems and Techniques (Chania, Crete, Greece) pp 7-10
15. Demers J R, Logan R T and Brown E R 2007 An optically integrated coherent frequency-domain THz spectrometer with signal-to-noise ratio up to 80 dB Proc. IEEE Int. Topical Meeting on Microwave Photonics pp 92-5
16. Schneider A, Neis M, Stillhart M, Ruiz B, Khan R U A and Günter P 2006 Generation of terahertz pulses through optical rectification in organic DAST crystals theory and experiment J. Opt. Soc. Am. B 23 1822
17. Siebert K J, Loffler T, Quast H, Thomson M, Bauer T, Leonhardt R, Czasch S and Roskos H G 2002 Phys. Med. Biol. 47 3743
18. Chen H T and Kersting R 2003 Appl. Phys. Lett. 83 3009
19. Plusquellic D F, Siegrist K, Heilweil E J and Esenturk O 2007 Applications of terahertz spectroscopy in biosystems Chemphyschem 8 2412-31
20. Ferguson B, Wang S, Gray D, Abbott D and Zhang X C 2002 Towards functional 3D T-ray imaging Phys. Med. Biol. 47 3735-42
21. Smye W, Chamberlain J M, Fitzgerald A J and Berry E 2001 The interaction between Terahertz radiation and biological tissue Phys. Med. Biol. 46 R101-12
22. Globus T R, Woolard D L, Khromova T, Crowe T W, Bykhovskaia M, Gelmont B L, Hesler J and Samuels A C 2003 THz-spectroscopy of biological molecules J. Biol. Phys. 29 89
23. Kikuchi N, Tanno T, Watanabe M and Kurubayashi T 2009 A membrane method for terahertz spectroscopy of amino acids Anal. Sci. 25 457
24. Opportunities in THz science Report of a DOE-NSF-NIH Workshop (Arlington, VA) ed M S Sherwin et al 2004
25. D'Esposito M 2000 Functional neuroimaging of cognition Semin. Neurol. 20 487-98
26. Villringer A and Dirnagl U 1995 Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging Cerebrovasc. Brain Metab. Rev. 7 240-76
27. Laufs H, Daunizeau J, Carmichael D W and Kleinschmidt A 2008 Recent advances in recording electrophysiological data simultaneously with magnetic resonance imaging Neuroimage 40 515-28
28. Hariri A R, Drabant E M and Weinberger D R 2006 Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing Biol. Psychiatry 59 888-97
29. Lan M J, McLoughlin G A, Griffin J L, Tsang T M, Huang J T, Yuan P, Manji H, Holme E and Bahn S 2008 Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder Mol. Psychiatry 14 269-79 doi:10.1038/sj.mp.4002130
30. ngür D, Jensen J E, Prescot A P, Stork C, Lundy M, Cohen B M and Renshaw P F 2008 Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania Biol. Psychiatry 64 718-26
31. Png G M, Flook R, Ng B W-H and Abbott D 2009 Mar 26 Terahertz spectroscopy of snap-frozen human brain tissue: an initial study Electron. Lett. 45 343-5
32. Png G M et al 2008 The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements Phys. Med. Biol. 53 3501-17