Determination and pharmacokinetic study of hydrocodone in human plasma by liquid chromatography coupled with tandem mass spectrometry

Artificial Cells, Blood Substitutes, and Biotechnology

Volumn 37, Issue 5, 2009, Pages 203-207

  Zhang, Rui ^a   Wang, Benjie ^a   Wei, Chunmin ^a   Yuan, Guiyan ^a   Guo, Ruichen ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bioequivalence; HPLC MS MS; Hydrocodone; Pharmacokinetic

Indexed keywords

BIOEQUIVALENCE; BIOEQUIVALENCE STUDY; CHROMATOGRAPHIC CONDITIONS; EXISTING METHOD; EXTRACTION METHOD; HIGHLY SENSITIVE; HPLC-MS-MS; HUMAN PLASMAS; HYDROCODONE; INTERNAL STANDARDS; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; MULTIPLE REACTIONS MONITORING; PHARMACOKINETIC STUDIES; SIMPLE LIQUIDS; TANDEM MASS SPECTROMETRY;

ACETONITRILE; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILE; CANRENONE; HYDROCODONE; HYDROCODONE BITARTRATE; PARACETAMOL;

ADULT; ANALGESIC ACTIVITY; ANALYTICAL EQUIPMENT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; HEPARINIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; ION MONITORING; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; PROCESS OPTIMIZATION; RANDOMIZED CONTROLLED TRIAL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANALGESICS, OPIOID; BLOOD CHEMICAL ANALYSIS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DRUG STABILITY; HUMANS; HYDROCODONE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 70350681107     PISSN: 10731199     EISSN: 15324184     Source Type: Journal    
DOI: 10.1080/10731190903198574     Document Type: Article

References (3)

1. Zheng, H. (2004). Medicinal Chemistry [M]. 5th, ed, People's Health Press, Beijing, pp 40-41.
2. Wu, J. (1997). Studies on the analysis of hydrocodone and its metabolite in human urine by GC/MS. Acta Pharmaceutica Sinica 32(4):305-309.
3. Chen, Yu-Luan, Hanson, Glenn D., Jiang, Xiangyu, et al. (2002). Simultaneous determination of hydrocodone and hydromorphone in human plasma by liquid chromatography with tandem mass spectrometric detection. Journal of Chromatography B, 769:55-64.