Optimization by factorial design of a capillary electrophoresis method for the chiral resolution and determination of zopiclone and its synthesis precursor

Journal of Liquid Chromatography and Related Technologies

Volumn 32, Issue 18, 2009, Pages 2654-2668

  Gomis, Domingo Blanco ^a   Velasco, Cristina Botas ^a   Sanchez, Ignacio Herrero ^b   Alvarez, M Dolores Gutierrez ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Asturpharma SA   (Spain)

Author keywords

Capillary electrophoresis; Chiral; Cyclodextrin; Experimental design; Zopiclone

Indexed keywords

CAPILLARY ELECTROPHORETIC METHODS; CHIRAL; CHIRAL INTERMEDIATES; CHIRAL RESOLUTIONS; DETECTION LIMITS; EFFECTIVE LENGTH; ENANTIOMERIC PURITY; EXPERIMENTAL DESIGN; FACTORIAL DESIGN; FUSED-SILICA CAPILLARIES; INNER DIAMETERS; INTERNAL STANDARDS; INTERNATIONAL CONFERENCE ON HARMONIZATIONS; PHOSPHATE BUFFERS; UV DETECTION; ZOPICLONE;

CAPILLARY ELECTROPHORESIS; COMPLEXATION; DESIGN; ELECTROCHEMISTRY; SILICA; STATISTICS; UREA;

FUSED SILICA;

BETA CYCLODEXTRIN; DIAZEPAM; HYPNOTIC AGENT; UNCLASSIFIED DRUG; UREA; ZOPICLONE; ZOPICLONE 2;

ACCURACY; ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PURIFICATION; DRUG SOLUBILITY; DRUG STRUCTURE; ENANTIOMER; FACTORIAL DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; PH; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; ULTRAVIOLET RADIATION; VALIDITY;

EID: 70350676005     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070903245672     Document Type: Article

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