In vitro permeation characterization of repellent picaridin and sunscreen oxybenzone

Pharmaceutical Development and Technology

Volumn 14, Issue 3, 2009, Pages 332-340

  Gu, Xiaochen ^a   Chen, Ting ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Concurrent use; In vitro diffusion; Insect repellent picaridin; Permeability; Sunscreen oxybenzone

Indexed keywords

DIETHYLTOLUAMIDE; DIMETICONE; INSECT REPELLENT; OXYBENZONE; PICARIDIN; SUNSCREEN; UNCLASSIFIED DRUG; ARTIFICIAL MEMBRANE; BAYSILON; BENZOPHENONE DERIVATIVE; ICARIDIN; PIPERIDINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG PENETRATION; EPIDERMIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEMBRANE TRANSPORT; PRIORITY JOURNAL; SKIN PERMEABILITY; ARTIFICIAL MEMBRANE; METABOLISM; PERMEABILITY; SKIN ABSORPTION;

BENZOPHENONES; DIFFUSION; DIMETHYLPOLYSILOXANES; EPIDERMIS; HUMANS; INSECT REPELLENTS; MEMBRANES, ARTIFICIAL; PERMEABILITY; PIPERIDINES; SKIN ABSORPTION; SUNSCREENING AGENTS;

EID: 70350662642     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802647318     Document Type: Article

References (27)

1. Katz TM, Miller JH, Hebert AA. Insect repellents: historical perspectives and new developments. J Am Acad Dermatol. 2008;58:865-871.
2. Fradin MS. Mosquitoes and mosquito repellents: a clinician's guide. Ann Int Med. 1998;128:931-940.
3. Staub D, Debrunner M, Amsler L, Steffen R. Effectiveness of a repellent containing DEET and EBAAP for preventing tick bites. Wilderness Environ Med. 2002;13:12-20.
4. Koren G, Matsui D, Bailey B. DEET-based insect repellents: safety implications for children and pregnant and lactating women. Can Med Assoc J. 2003;169:209-212.
5. Qiu H, Jun HW, Tao J. Pharmacokinetics of insect repellent N,N-diethyl-m-toluamide in beagle dogs following intravenous and topical routes of administration. J Pharm Sci. 1997;86:514-516.
6. Robbins PJ, Cherniak MG. Review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET). J Toxicol Environ Health. 1986;18:503-525.
7. Abdel-Rahman A, Abou-Donia SM, El-Masry EM, Shetty AK, Abou-Donia MB. Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. J Toxicol Environ Health A. 2004;67:163-192.
8. Abdel-Rahman A, Dechkovskaia AM, Goldstein LB, Bullman SH, Khan W, El-Masry EM, Abou-Donia MB. Neurologivcal deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. J Toxicol Environ Health A. 2004;67:331-356.
9. Naucke TJ, Kröpke R, Benner G, Schulz J, Wittern KP, Rose A, Kröckel U, Grünewald HW. Field evaluation of the efficacy of proprietary repellent formulations with IR3535 and picaridin against Aedes aegypti. Parastol Res. 2007;101:169-177.
10. Zhu J, Zeng X, O'Neal M, Schultz G, Tucker B, Coats J, Bartholomay L, Xue RD. Mosquito larvicidal activity of botanical- based mosquito repellents. J Am Mosq Control Assoc. 2008;24:161-168.
11. Chatelain E, Gabard B, Surber C. Skin penetration and sun protection factor of five UV filters: effect of the vehicle. Skin Pharmacol Appl Skin Physiol. 2003;16:28-35.
12. Felton LA, Wiley CJ, Godwin DA. Influence of cyclodextrin complexation on the in vivo photoprotective effects of oxybenzone. Drug Dev Ind Pharm. 2004;30:95-102.
13. Hayden CJ, Roberts MS, Benson HAE. Systemic absorption of sunscreen after topical application. Lancet. 1997;350:863-864.
14. Pont AR, Charron AR, Brand RM. Active ingredients act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol. 2004;195:348-354.
15. Montemarano AD, Gupta RK, Burge JR, Klein K. Insect repellents and the efficacy of sunscreen. Lancet. 1997;349:1670-1671.
16. Murphy ME, Montemarano AD, Debboun M, Gupta R. The effect of sunscreen on the efficacy of insect repellent: a clinical trial. J Am Acad Dermatol. 2000;43:219-222.
17. Gu X, Kasichayanula S, Fediuk DJ, Burczynski FJ. In-vitro permeation of the insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone. J Pharm Pharmacol. 2004;56:621-628.
18. Gu X, Wang T, Collins DM, Kasichayanula S, Burczynski FJ. In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations. Br J Dermatol. 2005;152:1263-1267.
19. Wang T, Gu X. Permeation of repellent DEET and sunscreen oxybenzone across human skin. J Pharm Pharm Sci. 2007;10:17-25.
20. Kasichayanula S, House JD, Wang T, Gu X. Percutaneous characterization of the insect repellent DEET and the sunscreen oxybenzone from topical skin application. Toxicol App Pharmacol. 2007;223:187-194. (Pubitemid 47348062)
21. Crank J. The mathematics of diffusion. 2nd ed. New York: Oxford University Press; 1975.
22. Feldmann RJ, Maibach HI. Regional variation in percutaneous penetration of 14C cortisol in man. J Invest Dermatol. 1967;48:181-183.
23. Scheuplein RJ. The physiology and pathophysiology of the skin. In: ed. Jarrett A. Site variations in diffusion and permeability. New York: Academic Press; 1978:1731-1752.
24. Stamatialis DF, Rolevink HHM Koops GH. Controlled transport of timolol maleate through artificial membranes under passive and iontophoretic conditions. J Control Release. 2002;81:335-345.
25. Dias M, Farinha A, Faustino E, Hadgraft J, Pais J, Toscano C. Topical delivery of caffeine from some commercial formulations. Int J Pharm .1999;182:41-47.
26. Jiang R, Benson HA, Cross SE, Roberts MS. In vitro human epidermal and polyethylene membrane penetration and retention of the sunscreen benzophenone-3 from a range of solvents. Pharm Res. 1998;15:1863-1868.
27. Wissing SA, Müller RH. Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration. J Control Release. 2002;81:225-233.