Anti-ulcerogenic activity of two extracts of Parquetina nigrescens and their effects on mucosal antioxidants defense system on ethanol-induced ulcer in rats

Research Journal of Medicinal Plant

Volumn 3, Issue 3, 2009, Pages 102-108

  Kayode, A A A ^a   Kayode, O T ^b   Odetola, A A ^b  

^a BELLS UNIVERSITY OF TECHNOLOGY   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Antioxidant enzymes; Antiulcer activity; Free radicals; Mucosa; Parquentina nigrescens

Indexed keywords

ALCOHOL; ANTIULCER AGENT; CATALASE; CHLOROFORM; CIMETIDINE; GLUTATHIONE; HEXANE; OLIVE OIL; PARQUETINA NIGRESCENS EXTRACT; PLANT EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; LIVER HOMOGENATE; MALE; NONHUMAN; PARQUETINA NIGRESCENS; PLANT; RAT; STOMACH INJURY; STOMACH MUCOSA; STOMACH ULCER;

PARQUETINA NIGRESCENS; RATTUS;

EID: 70350661996     PISSN: 18193455     EISSN: None     Source Type: Journal    
DOI: 10.3923/rjmp.2009.102.108     Document Type: Article

References (29)

1. Adeyemi, S.O., 1994. Ethnobotanical study of the antirrheumatic plants in part of Oyo, Ogun and Lagos States. University of Ibadan.
2. Agnihotri, N., H. Kaur, N. Kaur and P. Sarotra, 2007. Role of oxidative stress in lansoprasole-mediated gastric and hepatic protection in Wistar rat. Indian J. Gastroenterol., 26: 118-121.
3. Bamgboye, E.A., 20Q2. A Companion of Medical Statistics. Fobam Pblishers, Ibadan, ISBN: 9780566619.
4. Brock, W.D., H.J. Trochimowicz, R.J.H. Millischer, C. Farr, T. Kawano and G.M. Rusch, 1995. Acute and subchronic toxicity of 1, 1-dichloro-1-fluroethane (HCFC-141b). Food Chem. Toxicol., 33: 483-490.
5. Clairborne, A., 1989. Catalase Activity. In: Handbook of Methods for Oxygen Radical Research, Greenwald, A.R. (Ed.). CRC Press, Florida, pp: 237-242.
6. Coskun, O., M. Kanter, F. Armutcu, K. Cetin, B. Kaybolmaz and O. Yazgan, 2004. Protective effect of quercetin, a flavonoid antioxidant, in absolute ethanol-induced acute gastric ulcer. Eur. J. Gen. Med., 1: 37-42.
7. Datte, J.Y., A. Ziegler and J.P. Tillement, 1999. Sympathomimetic effects of Parquetina nigresens (Periplocaceae) extract in isolated portal vein smooth muscle. Gen. Pharmacol., 32, 551-556.
8. Gill, L.S., 1992. Ethnomedical Uses of Plants in Nigeria. 1st Edn., Uniben Press, Benin City, ISBN: 978-2027-20-0, pp: 180-181.
9. Halliwell, B., 1999. Antioxidants defense mechanisms: From the beginning to the end. Free Radic. Res., 31: 261-272.
10. Hayes, A.W., 1987. Guidelines of Acute Oral Toxicity Testing. 2nd Edn., Raven Press Ltd., New York, pp: 185.
11. Irvine, F.R., 1961. Woody Plants of Ghana, Special Reference to their Uses. Oxford University Press, London.
12. Iwu, M.M., 1993. Handbook of African Medicinal Plants. 1st Edn., CRC Press, Boca Raton, FL., ISBN-10: 084934266X.
13. Jollow, D.J., J.R. Mitchell, N. Zampaghonic and J.R. Gillette, 1974. Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzeneoxide as the hepatotoxic metabolite. Pharmacology, 11: 151-169.
14. Kokwaro, J.O., 1976. Medicinal Plants of East Africa. 1st Edn., East Africa Literature Bureau, Nairobi, pp: 58-59.
15. Kokwaro, J.O., 1993. Medicinal Plants of East Africa. 2nd Edn., Kenya Literature Bureau, Nairobi.
16. Lee, E.B., O.J. Kim, S.S. Kang and C. Jeong, 2005. Araloside A, an antiulcer constituent from the root bark of Aralia elata. Biol. Pharm. Bull., 28: 523-426.
17. Lowry, O.H., N. J. Rosebrough, AL. Farr and R. J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
18. Lutomski, J., C. Nieman and G.R. Fenwick, 1991. Liquonce, glycyrrhiza Glabra L. Biological Herba Polonica Tom, 37: 163-178.
19. Mabberly, D.J., 1987. The Plant-Book. A Portable Dictionary of the Higher Plants. Cambridge University Press, Cambridge.
20. Magwere, T., Y.S. Naik and J.A. Hasler, 1997. Effect of choloquine treatment on antioxidant enzymes in rats liver and kidney. Free Radic. Biol. Med., 22: 321-327.
21. Misra, H.P. and I. Fridovich, 1972.. The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem., 247: 3170-3175.
22. Nwafor, A., F. Paul, K. Okwasaba and L. G. Binda, 2000. Antidiarrhoeal and antoulcerogenic effect of methanolic extract of Asparagus pubescens root in rats. J. Ethnopharmacol., 72: 421-427.
23. Oliver, B., 1960. Medicinal Plants in Nigeria. University of Ibadan Press, Ibadan, Nigeria,
24. Priscilla, C.M. and S.T. Heather, 2000. Antioxidants: What role do they play in physical activity and health? Am. J. Clin. Nutr., 72: 637s-646s.
25. Repetto, M.G. and S.F. Llesuy, 2002. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res., 35: 523-534.
26. Rodriguez, Z.B.Z., R.G. Alvarez, D. Guanche, N. Merino and F.H. Rosales et al., 2007. Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcer in rats. Mediators Inflammat., 2007: 65873-65873.
27. Sandhir, R. and K.D. Grill, 1999. Hepatoprotective effects of Liv-52 on ethanol-induced liver damage in rats. Ind. J. Exp. Biol., 37: 762-766.
28. Shah, J.S., M.B. Shah, S.S. Goswami and D.D. Santani, 2006. Mechanism of action of antiulcer activity of bark extracts of Manikara hexandra against experimentally induced gastric ulcers in rats. Phcog. Mag., 2: 40-45.
29. Sheth, U.K., N.K. Dadkar and U.G. Kamat, 1972. Selected Topics in Experimental Pharmacology. The Kothari Book Depot, Bombay, India.