Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection

Immunopharmacology and Immunotoxicology

Volumn 31, Issue 2, 2009, Pages 238-245

  Chen, Rui ^a,b   Moriya, Junji ^a   Luo, Xianwen ^c   Yamakawa, Jun Ichi ^a   Takahashi, Takashi ^a   Sasaki, Kenroh ^d   Yoshizaki, Fumihiko ^d  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

B cell lymphoma 2 (Bcl 2); Brain derived neurotrophic factor (BDNF); Chronic fatigue syndrome; Hochu ekki to (TJ 41); Interferon gamma; Natural killer cell activity

Indexed keywords

BACTERIAL ANTIGEN; BRAIN DERIVED NEUROTROPHIC FACTOR; BU ZHONG YI QI TANG; GAMMA INTERFERON; MESSENGER RNA; PROTEIN BCL 2; BU-ZHONG-YI-QI-TANG; HERBACEOUS AGENT; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN ATROPHY; BRAIN PROTECTION; BRAIN WEIGHT; BRUCELLA ABORTUS; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOSTIMULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; ORGAN WEIGHT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RUNNING; SPLEEN WEIGHT; THYMUS; ANIMAL; BAGG ALBINO MOUSE; DAILY LIFE ACTIVITY; DRUG EFFECTS; FATIGUE SYNDROME, CHRONIC; IMMUNOLOGY; MOTOR ACTIVITY; ORGAN SIZE; PATHOLOGY; PROTO ONCOGENE; SPLEEN;

BRUCELLA MELITENSIS BIOVAR ABORTUS; MUS;

ACTIVITIES OF DAILY LIVING; ANIMALS; ANTIGENS, BACTERIAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; BRUCELLA ABORTUS; DRUGS, CHINESE HERBAL; FATIGUE SYNDROME, CHRONIC; FEMALE; GENES, BCL-2; HIPPOCAMPUS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; ORGAN SIZE; SPLEEN; THYMUS GLAND;

EID: 70350648448     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970802391525     Document Type: Article

References (32)

1. Fukuda, K.; Straus, S.E.; Hickie, I.; Sharpe, M.C.; Dobbins, J.G.; Komaroff, A. The chronic fatigue syndrome. A comprehensive approach to its definition and study. Ann Intern Med. 1994, 121 (12):953-959.
2. Katafuchi, T.; Kondo, T.; Take, S.; Yoshimura, M. Brain cytokines and the 5-HT system during poly I:C-induced fatigue. Ann N Y Acad Sci. 2006, 1088:230-237.
3. Rook, G.A.; Zumla, A. Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? Lancet. 1997, 349 (9068):1831-1833.
4. de Lange, F.P.; Kalkman, J.S.; Bleijenberg, G.; Hagoort, P.; van der Meer, J.W.; Toni, I. Gray matter volume reduction in the chronic fatigue syndrome. Neuroimage. 2005, 26 (3):777-781.
5. Brooks, J.C.; Roberts, N.; Whitehouse, G.; Majeed, T. Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome. Br J Radiol. 2000, 73 (875):1206-1208.
6. Wang, X.Q.; Takahashi, T.; Zhu, S.J.; Moriya, J.; Saegusa, S.; Yamakawa, J.; Kusaka, K.; Itoh, T.; Kanda, T. Effect of Hochuekki- to (TJ-41), a Japanese herbal medicine, on daily activity in a murine model of chronic fatigue syndrome. Evid Based Complement Alternat Med. 2004, 1 (2):203-206.
7. Moriya, J. Establishment of murine model for chronic fatigue syndrome and efficacy of kampo medicine on daily activity. J Kanazawa Med Univ. 2006, 31:1-6.
8. Chen, R.; Moriya, J.; Yamakawa, J.I.; Takahashi, T.; Li, Q.; Morimoto, S.; Iwai, K.; Sumino, H.; Yamaguchi, N.; Kanda, T. Brain Atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochem Res. Mar 4., 2008, [Epub ahead of print].
9. Carlo-Stella, N.; Badulli, C.; De Silvestri, A.; Bazzichi, L.; Martinetti, M.; Lorusso, L.; Bombardieri, S.; Salvaneschi, L.; Cuccia, M. A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles. Clin Exp Rheumatol. 2006, 24 (2):179-182.
10. Lee, J.; Kim, S.J.; Son, T.G.; Chan, S.L.; Mattson, M.P. Interferongamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity. J Neurosci Res. 2006, 83 (8):1552-1557.
11. Ottenweller, J.E.; Natelson, B.H.; Gause, W.C.; Carroll, K.K.; Beldowicz, D.; Zhou, X.D.; LaManca, J.J. Mouse running activity is lowered by Brucella abortus treatment: A potential model to study chronic fatigue. Physiol Behav. 1998, 63 (5):795-801.
12. Kanda, T.; McManus, J.E.; Nagai, R.; Imai, S.; Suzuki, T.; Yang, D.; McManus, B.M.; Kobayashi, I. Modification of viral myocarditis in mice by interleukin-6. Circ Res. 1996, 78 (5):848-856.
13. Becker, P.D.; McGregor, N.; Meirleir, K.D. Possible triggers and mode of onset of chronic fatigue syndrome. J Chronic Fatigue Syndr. 2002, 10:3-18.
14. Prins, J.B.; van der Meer, J.W.; Bleijenberg, G. Chronic fatigue syndrome. Lancet. 2006, 367 (9507):346-355.
15. Parker, N.R.; Barralet, J.H.; Bell, A.M. Q fever. Lancet. 2006, 367 (9511):679-688.
16. Tarello, W. Chronic fatigue syndrome (CFS) associated with Staphylococcus spp. bacteremia, responsive to potassium arsenite 0.5 % in a veterinary surgeon and his coworking wife, handling with CFS animal cases. Comp Immunol Microbiol Infect Dis. 2001, 24 (4):233-246.
17. Hickie, I.; Davenport, T.; Wakefield, D.; Vollmer-Conna, U.; Cameron, B.; Vernon, S.D.; Reeves, W.C.; Lloyd, A. (Dubbo Infection Outcomes Study Group.) Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ 2006, 333 (7568):575-580.
18. Sacks, N.; Van Rensburg, A.J. Clinical aspects of chronic brucellosis. S Afr Med J. 1976, 50 (19):725-728.
19. Natelson, B.H.; LaManca, J.J.; Denny, T.N.; Vladutiu, A.; Oleske, J.; Hill, N.; Bergen, M.T.; Korn, L.; Hay, J. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis. Am J Med. 1998, 105 (3A):43S-49S.
20. Chao, C.C.; Janoff, E.N.; Hu, S.X.; Thomas, K.; Gallagher, M.; Tsang, M.; Peterson, P.K. Altered cytokine release in peripheral blood mononuclear cell (PBMC) cultures from patients with the chronic fatigue syndrome (CFS). Cytokine. 1991, 3 (4):292-298.
21. Tirelli, V.; Pinto, A.; Marotta, G.; Crovato, M.; Quaia, M.; De Paoli, P.; Galligioni, E.; Santini, G. Clinical and immunologic study of 205 patients with chronic fatigue syndrome: A case series from Italy. Arch Intern Med. 1993, 153 (1): 116-117, 120.
22. Strowig, T.; Brilot, F.; Münz, C. Noncytotoxic functions of NK cells: Direct pathogen restriction and assistance to adaptive immunity. J Immunol. 2008, 180 (12):7785-7791.
23. Kato, Y.; Morikawa, A.; Sugiyama, T.; Koide, N.; Jiang, G.Z.; Lwin, T.; Yoshida, T.; Yokochi, T. Augmentation of lipopolysaccharide- induced thymocyte apoptosis by interferon-gamma. Cell Immunol. 1997, 177 (2):103-108.
24. Cook, D.B.; O'Connor, P.J.; Lange, G. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage. 2007, 36 (1):108-122.
25. Beck, T.; Lindholm, D.; Castrén, E.; Wree, A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J Cereb Blood Flow Metab. 1994, 14 (4):689-692.
26. Martinowich, K.; Manji, H.; Lu, B. New insights into BDNF function in depression and anxiety. Nat Neurosci. 2007, 10 (9):1089-1093.
27. Sasaki, T.; Kitagawa, K.; Yagita, Y.; Sugiura, S.; Omura- Matsuoka, E.; Tanaka, S.; Matsushita, K.; Okano, H.; Tsujimoto, Y.; Hori, M. 2006. Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus. J Neurosci Res. 84 (6):1187-1196.
28. Zhong, L.T.; Sarafian, T.; Kane, D.J.; Charles, A.C.; Mah, S.P.; Edwards, R.H.; Bredesen, D.E. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA. 1993, 90 (10):4533-4537.
29. Vaynman, S.; Ying, Z.; Gomez-Pinilla, F. The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience. 2007, 144 (3):825-833.
30. Wang, X.J.; Ichikawa, H.; Konishi, T. Antioxidant potential of qizhu tang, a chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia reperfusion in rats. Biol Pharm Bull. 2001, 24 (5):558-563.
31. Shih, H.C.; Chang, K.H.; Chen, F.L.; Chen, C.M.; Chen, S.C.; Lin, Y.T.; Shibuya, A. Anti-aging effects of the traditional Chinese medicine bu-zhong-yi-qi-tang in mice. Am J Chin Med. 2000, 28 (1):77-86.
32. Geiger, K.D.; Nash, T.C.; Sawyer, S.; Krahl, T.; Patstone, G.; Reed, J.C.; Krajewski, S.; Dalton, D.; Buchmeier, M.J.; Sarvetnick, N. Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death. Virology. 1997, 238 (2):189-197.