Management of conjunctival melanoma

Expert Review of Anticancer Therapy

Volumn 9, Issue 9, 2009, Pages 1227-1239

  Damato, Bertil ^a   Coupland, Sarah E ^b  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Brachytherapy; Conjunctiva; Conjunctival melanocytic intra epithelial neoplasia; Cryotherapy; Grading; Melanoma; Melanoma in situ; Melanosis; Mitomycin C; Primary acquired melanosis; Staging; Treatment

Indexed keywords

MITOMYCIN C;

BRACHYTHERAPY; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER INVASION; CANCER RADIOTHERAPY; CANCER STAGING; CARCINOMA IN SITU; CLINICAL FEATURE; CLINICAL TRIAL; CONJUNCTIVA MELANOMA; CRYOTHERAPY; EVISCERATION; HISTOPATHOLOGY; HUMAN; MELANOCYTE; MELANOMA; MELANOSIS; METASTASIS; NEVUS; REVIEW; SCORING SYSTEM; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADMINISTRATION, TOPICAL; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; CONJUNCTIVAL NEOPLASMS; CRYOTHERAPY; HUMANS; MELANOMA; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; TREATMENT OUTCOME;

EID: 70350627357     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/ERA.09.85     Document Type: Review

References (35)

1. Damato B, Coupland SE. Clinical mapping of conjunctival melanomas. Br. J. Ophthalmol. 92(11), 1545-1549 (2007) • Novel method of describing the size and extent of conjunctival melanomas.
2. Damato B, Coupland SE. Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging. Clin. Experiment. Ophthalmol. 36(8), 786-795 (2008). •• Overview of the subject, including a novel method of grading conjunctival melanocytic intra-epithelial neoplasia (C-MIN).
3. Reese AB. Precancerous and cancerous melanosis. Am. J. Ophthalmol. 61(5), 1272-1277 (1966).
4. Paridaens AD, McCartney AC, Minassian DC, Hungerford JL. Orbital exenteration in 95 cases of primary conjunctival malignant melanoma. Br. J. Ophthalmol. 78(7), 520-528 (1994).
5. Jakobiec FA, Rini FJ, Fraunfelder FT, Brownstein S. Cryotherapy for conjunctival primary acquired melanosis and malignant melanoma: experience with 62 cases. Ophthalmology 95(8), 1058-1070 (1988). (Pubitemid 18194895)
6. Shields JA, Shields CL, De Potter P. Surgical management of circumscribed conjunctival melanomas. Ophthal. Plast. Reconstr. Surg. 14(3), 208-215 (1998). • Description of the most widely-used method of treating conjunctival melanoma. (Pubitemid 28244041)
7. Finger PT, Milner MS, McCormick SA. Topical chemotherapy for conjunctival melanoma. Br. J. Ophthalmol. 77(11), 751-753 (1993).
8. Frucht-Pery J, Peer J. Use of Mitomycin C in the treatment of conjunctival primary acquired melanosis with atypia. Arch. Ophthalmol. 114, 1261-1264 (1996). (Pubitemid 26338859)
9. Treacher Collins E. Case of epibulbar sarcoma cured by its removal and the application of radium. Trans. Ophthal. Soc. UK 38, 125-127 (1918).
10. Lederman M, Wybar K, Busby E. Malignant epibulbar melanoma: natural history and treatment by radiotherapy. Br. J. Ophthalmol. 68, 605-617 (1984). (Pubitemid 15136073)
11. Missotten GS, Keijser S, de Keizer RJ, Wolff-Rouendaal D. Conjunctival melanoma in the Netherlands: a nationwide study. Invest. Ophthalmol. Vis. Sci. 46(1), 75-82 (2005). • Report on outcomes after treatment of conjunctival melanoma. (Pubitemid 40041181)
12. Anastassiou G, Heiligenhaus A, Bechrakis N, Bader E, Bornfeld N, Steuhl KP. Prognostic value of clinical and histopathological parameters in conjunctival melanomas: a retrospective study. Br. J. Ophthalmol. 86(2), 163-167 (2002). • Report on outcomes after treatment of conjunctival melanoma. (Pubitemid 38867452)
13. Shields CL. Conjunctival melanoma: risk factors for recurrence, exenteration, metastasis, and death in 150 consecutive patients. Trans. Am. Ophthalmol. Soc. 98, 471-492 (2000). • Large study reporting outcomes after treatment of conjunctival melanoma.
14. Desjardins L, Poncet P, Levy C, Schlienger P, Asselain B, Validire P. Prognostic factors in malignant melanoma of the conjunctiva: an anatomo-clinical study of 56 patients. J. Fr. Ophtalmol. 22(3), 315-321 (1999). (Pubitemid 29206942)
15. Werschnik C , Lommatzsch PK. Long-term follow-up of patients with conjunctival melanoma. Am. J. Clin. Oncol. 25(3), 248-255 (2002). (Pubitemid 34602545)
16. Damato B, Coupland SE. An audit of conjunctival melanoma treatment in Liverpool. Eye 23(4), 801-809 (2008). •• Study of outcomes after treatment of conjunctival melanoma, with patients treated primarily at an oncology center being distinguished from those referred after treatment elsewhere.
17. TNM Staging Of Malignant Tumours (7th Edition). Sobin LH, Wittekind C (Eds.). Springer (2009).
18. Tuomaala S, Kivela T. Metastatic pattern and survival in disseminated conjunctival melanoma: implications for sentinel lymph node biopsy. Ophthalmology 111(4), 816-821 (2004). •• Informative study on metastatic spread. (Pubitemid 38429682)
19. Paridaens AD, Minassian DC, McCartney AC, Hungerford JL. Prognostic factors in primary malignant melanoma of the conjunctiva: a clinicopathological study of 256 cases. Br. J Ophthalmol 78(4), 252-259 (1994). •• Large study on risk factors.
20. Keijser S, Missotten GS, Bonfrer JM, Wolff-Rouendaal D, Jager MJ, de Keizer RJ. Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Br. J. Ophthalmol. 90(2), 213-217 (2006). (Pubitemid 43163854)
21. Shields CL, Shields JA, Armstrong T. Management of conjunctival and corneal melanoma with surgical excision, amniotic membrane allograft, and topical chemotherapy. Am. J. Ophthalmol. 132(4), 576-578 (2001). (Pubitemid 32904587)
22. Zehetmayer M, Menapace R, Kulnig W. Combined local excision and brachytherapy with ruthenium-106 in the treatment of epibulbar malignancies. Ophthalmologica 207(3), 133-139 (1993). (Pubitemid 24001981)
23. Wuestemeyer H, Sauerwein W, Meller D et al. Proton radiotherapy as an alternative to exenteration in the management of extended conjunctival melanoma. Graefes Arch. Clin. Exp. Ophthalmol. 244(4), 438-446 (2006).
24. Zografos L, Uffer S, Bercher L, Gailloud C. Combined surgery, cryocoagulation and radiotherapy for treatment of melanoma of the conjunctiva. Klin. Monatsbl. Augenheilkd. 204(5), 385-390 (1994). (Pubitemid 24199373)
25. Stannard CE, Sealy GR, Hering ER, Pereira SB, Knowles R, Hill JC. Malignant melanoma of the eyelid and palpebral conjunctiva treated with iodine-125 brachytherapy. Ophthalmology 107(5), 951-958 (2000). (Pubitemid 30728007)
26. Tuomaala S, Kivela T. Sentinel lymph node biopsy guidelines for conjunctival melanoma. Melanoma Res. 18(3), 235 (2008). (Pubitemid 351684671)
27. Esmaeli B. Regional lymph node assessment for conjunctival melanoma: sentinel lymph node biopsy and positron emission tomography. Br. J. Ophthalmol. 92(4), 443-445 (2008).
28. Folberg R , McLean IW. Primary acquired melanosis and melanoma of the conjunctiva: terminology, classification, and biologic behavior. Hum. Pathol. 17, 652-654 (1986). •• An early study correlating histological features of C-MIN with subsequent development of invasive melanoma. (Pubitemid 16070406)
29. Shields JA, Shields CL, Mashayekhi A et al. Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture. Ophthalmology 115(3), 511-519 (2008). •• A large study on C-MIN, correlating histological features with development of invasive melanoma.
30. Folberg R, McLean IW, Zimmerman LE. Primary acquired melanosis of the conjunctiva. Hum. Pathol. 16(2), 129-135 (1985).
31. Sugiura M, Colby KA, Mihm MC Jr, Zembowicz A. Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: clinicopathologic analysis of 29 cases. Am. J. Surg. Pathol. 31(2), 185-192 (2007). • Recent study correlating histological features of C-MIN with risk of invasive melanoma. (Pubitemid 46175018)
32. Chalasani R, Giblin M, Conway RM. Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment. Clin. Experiment. Ophthalmol. 34(7), 708-714 (2006). (Pubitemid 44363625)
33. Ackerman AB, Sood R, Koenig M. Primary acquired melanosis of the conjunctiva is melanoma in situ. Mod. Pathol. 4(2), 253-263 (1991). • An argument in favor of considering C-MIN to be regarded as melanoma in situ.
34. TNM Classification of Malignant Tumours (6th Edition). Sobin LH, Wittekind C (Eds). Wiley-Liss, NY, USA (2002).
35. Damato BE, Dopierala J, Klaasen A, van Dijk M, Sibbring J, Coupland SE. Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death. Invest. Ophthalmol. Vis. Sci. 50(7), 3048-3055 (2009).