-
1
-
-
45549085992
-
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase
-
Wei C.C., Wang Z.Q., Tejero J., Yang Y.P., Hemann C., Hille R., et al. Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. J. Biol. Chem. 283 (2008) 11734-11742
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11734-11742
-
-
Wei, C.C.1
Wang, Z.Q.2
Tejero, J.3
Yang, Y.P.4
Hemann, C.5
Hille, R.6
-
2
-
-
0032482975
-
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors
-
Vasquez-Vivar J., Kalyanaraman B., Martasek P., Hogg N., Masters B.S., Karoui H., et al. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 9220-9225
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 9220-9225
-
-
Vasquez-Vivar, J.1
Kalyanaraman, B.2
Martasek, P.3
Hogg, N.4
Masters, B.S.5
Karoui, H.6
-
3
-
-
85047690420
-
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
-
Alp N.J., Mussa S., Khoo J., Guzik T.J., Cai S., Jefferson A., et al. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J. Clin. Invest. 112 (2003) 725-735
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 725-735
-
-
Alp, N.J.1
Mussa, S.2
Khoo, J.3
Guzik, T.J.4
Cai, S.5
Jefferson, A.6
-
4
-
-
0033512422
-
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta
-
Shinozaki K., Kashiwagi A., Nishio Y., Okamura T., Yoshida Y., Masada M., et al. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta. Diabetes 48 (1999) 2437-2445
-
(1999)
Diabetes
, vol.48
, pp. 2437-2445
-
-
Shinozaki, K.1
Kashiwagi, A.2
Nishio, Y.3
Okamura, T.4
Yoshida, Y.5
Masada, M.6
-
5
-
-
17744386526
-
A pivotal role for tetrahydrobiopterin in pulmonary hypertension
-
Khoo J.P., Zhao L., Alp N.J., Bendall J.K., Nicoli T., Rockett K., et al. A pivotal role for tetrahydrobiopterin in pulmonary hypertension. Circulation 111 (2005) 2126-2133
-
(2005)
Circulation
, vol.111
, pp. 2126-2133
-
-
Khoo, J.P.1
Zhao, L.2
Alp, N.J.3
Bendall, J.K.4
Nicoli, T.5
Rockett, K.6
-
6
-
-
35448929005
-
Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4
-
Dumitrescu C., Biondi R., Xia Y., Cardounel A.J., Druhan L.J., Ambrosio G., et al. Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 15081-15086
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 15081-15086
-
-
Dumitrescu, C.1
Biondi, R.2
Xia, Y.3
Cardounel, A.J.4
Druhan, L.J.5
Ambrosio, G.6
-
7
-
-
67649405068
-
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression
-
Tatham A.L., Crabtree M.J., Warrick N., Cai S., Alp N.J., and Channon K.M. GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. J. Biol. Chem. 284 (2009) 13660-13668
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13660-13668
-
-
Tatham, A.L.1
Crabtree, M.J.2
Warrick, N.3
Cai, S.4
Alp, N.J.5
Channon, K.M.6
-
8
-
-
0037399439
-
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
-
Landmesser U., Dikalov S., Price S.R., McCann L., Fukai T., Holland S.M., et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J. Clin. Invest. 111 (2003) 1201-1209
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1201-1209
-
-
Landmesser, U.1
Dikalov, S.2
Price, S.R.3
McCann, L.4
Fukai, T.5
Holland, S.M.6
-
9
-
-
0035887885
-
Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
-
Vasquez-Vivar J., Whitsett J., Martasek P., Hogg N., and Kalyanaraman B. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic. Biol. Med. 31 (2001) 975-985
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 975-985
-
-
Vasquez-Vivar, J.1
Whitsett, J.2
Martasek, P.3
Hogg, N.4
Kalyanaraman, B.5
-
10
-
-
0035814951
-
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
-
Laursen J.B., Somers M., Kurz S., McCann L., Warnholtz A., Freeman B.A., et al. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103 (2001) 1282-1288
-
(2001)
Circulation
, vol.103
, pp. 1282-1288
-
-
Laursen, J.B.1
Somers, M.2
Kurz, S.3
McCann, L.4
Warnholtz, A.5
Freeman, B.A.6
-
11
-
-
0033527413
-
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function
-
Milstien S., and Katusic Z. Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochem. Biophys. Res. Commun. 263 (1999) 681-684
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 681-684
-
-
Milstien, S.1
Katusic, Z.2
-
12
-
-
0038604446
-
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
-
Kuzkaya N., Weissmann N., Harrison D.G., and Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J. Biol. Chem. 278 (2003) 22546-22554
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22546-22554
-
-
Kuzkaya, N.1
Weissmann, N.2
Harrison, D.G.3
Dikalov, S.4
-
13
-
-
41849144894
-
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
-
Crabtree M.J., Smith C.L., Lam G., Goligorsky M.S., and Gross S.S. Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. Am. J. Physiol. Heart Circ. Physiol. 294 (2008) H1530-H1540
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.294
-
-
Crabtree, M.J.1
Smith, C.L.2
Lam, G.3
Goligorsky, M.S.4
Gross, S.S.5
-
14
-
-
59449086328
-
Quantitative regulation of intracellular endothelial nitric oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression
-
Crabtree M.J., Tatham A.L., Al-Wakeel Y., Warrick N., Hale A.B., Cai S., et al. Quantitative regulation of intracellular endothelial nitric oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression. J. Biol. Chem. 284 (2009) 1136-1144
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1136-1144
-
-
Crabtree, M.J.1
Tatham, A.L.2
Al-Wakeel, Y.3
Warrick, N.4
Hale, A.B.5
Cai, S.6
-
15
-
-
0034602878
-
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase
-
Heitzer T., Brockhoff C., Mayer B., Warnholtz A., Mollnau H., Henne S., et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ. Res. 86 (2000) E36-E41
-
(2000)
Circ. Res.
, vol.86
-
-
Heitzer, T.1
Brockhoff, C.2
Mayer, B.3
Warnholtz, A.4
Mollnau, H.5
Henne, S.6
-
16
-
-
0033752910
-
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
-
Heitzer T., Krohn K., Albers S., and Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 43 (2000) 1435-1438
-
(2000)
Diabetologia
, vol.43
, pp. 1435-1438
-
-
Heitzer, T.1
Krohn, K.2
Albers, S.3
Meinertz, T.4
-
17
-
-
0031018510
-
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
-
Stroes E., Kastelein J., Cosentino F., Erkelens W., Wever R., Koomans H., et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J. Clin. Invest. 99 (1997) 41-46
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 41-46
-
-
Stroes, E.1
Kastelein, J.2
Cosentino, F.3
Erkelens, W.4
Wever, R.5
Koomans, H.6
-
18
-
-
0242648530
-
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo
-
Nichol C.A., Lee C.L., Edelstein M.P., Chao J.Y., and Duch D.S. Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 1546-1550
-
(1983)
Proc. Natl. Acad. Sci. U. S. A.
, vol.80
, pp. 1546-1550
-
-
Nichol, C.A.1
Lee, C.L.2
Edelstein, M.P.3
Chao, J.Y.4
Duch, D.S.5
-
19
-
-
21144435142
-
Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
-
Chalupsky K., and Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 9056-9061
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 9056-9061
-
-
Chalupsky, K.1
Cai, H.2
-
20
-
-
70350496588
-
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: Relative importance of the de novo biopterin synthesis versus salvage pathways
-
Oct 9;
-
Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. J Biol Chem 2009 Oct 9;284:28128-36.
-
(2009)
J Biol Chem
, vol.284
, pp. 28128-28136
-
-
Crabtree, M.J.1
Tatham, A.L.2
Hale, A.B.3
Alp, N.J.4
Channon, K.M.5
-
21
-
-
67649781721
-
Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells
-
Sugiyama T., Levy B.D., and Michel T. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. J. Biol. Chem. 284 (2009) 12691-12700
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12691-12700
-
-
Sugiyama, T.1
Levy, B.D.2
Michel, T.3
-
22
-
-
40449104683
-
IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction
-
Ren J., Duan J., Thomas D.P., Yang X., Sreejayan N., Sowers J.R., et al. IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 (2008) R793-802
-
(2008)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.294
-
-
Ren, J.1
Duan, J.2
Thomas, D.P.3
Yang, X.4
Sreejayan, N.5
Sowers, J.R.6
-
23
-
-
57049176060
-
Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes
-
Ionova I.A., Vasquez-Vivar J., Whitsett J., Herrnreiter A., Medhora M., Cooley B.C., et al. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 295 (2008) H2178-H2187
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.295
-
-
Ionova, I.A.1
Vasquez-Vivar, J.2
Whitsett, J.3
Herrnreiter, A.4
Medhora, M.5
Cooley, B.C.6
-
24
-
-
0036790604
-
Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants
-
Vasquez-Vivar J., Duquaine D., Whitsett J., Kalyanaraman B., and Rajagopalan S. Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1655-1661
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 1655-1661
-
-
Vasquez-Vivar, J.1
Duquaine, D.2
Whitsett, J.3
Kalyanaraman, B.4
Rajagopalan, S.5
-
25
-
-
70350610765
-
Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity
-
Gao L, Chalupsky K, Stefani E, Cai H. Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity. J Mol Cell Cardiol 2009;47:752-760.
-
(2009)
J Mol Cell Cardiol
, vol.47
, pp. 752-760
-
-
Gao, L.1
Chalupsky, K.2
Stefani, E.3
Cai, H.4
-
26
-
-
0032570254
-
5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
-
Verhaar M.C., Wever R.M., Kastelein J.J., van Dam T., Koomans H.A., and Rabelink T.J. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97 (1998) 237-241
-
(1998)
Circulation
, vol.97
, pp. 237-241
-
-
Verhaar, M.C.1
Wever, R.M.2
Kastelein, J.J.3
van Dam, T.4
Koomans, H.A.5
Rabelink, T.J.6
-
27
-
-
0033609454
-
Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial
-
Verhaar M.C., Wever R.M., Kastelein J.J., van Loon D., Milstien S., Koomans H.A., et al. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial. Circulation 100 (1999) 335-338
-
(1999)
Circulation
, vol.100
, pp. 335-338
-
-
Verhaar, M.C.1
Wever, R.M.2
Kastelein, J.J.3
van Loon, D.4
Milstien, S.5
Koomans, H.A.6
-
28
-
-
0036020286
-
Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate
-
van Etten R.W., de Koning E.J., Verhaar M.C., Gaillard C.A., and Rabelink T.J. Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate. Diabetologia 45 (2002) 1004-1010
-
(2002)
Diabetologia
, vol.45
, pp. 1004-1010
-
-
van Etten, R.W.1
de Koning, E.J.2
Verhaar, M.C.3
Gaillard, C.A.4
Rabelink, T.J.5
-
29
-
-
0035721992
-
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
-
Doshi S.N., McDowell I.F., Moat S.J., Lang D., Newcombe R.G., Kredan M.B., et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1196-1202
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 1196-1202
-
-
Doshi, S.N.1
McDowell, I.F.2
Moat, S.J.3
Lang, D.4
Newcombe, R.G.5
Kredan, M.B.6
-
30
-
-
33748645122
-
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
-
Antoniades C., Shirodaria C., Warrick N., Cai S., de Bono J., Lee J., et al. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 114 (2006) 1193-1201
-
(2006)
Circulation
, vol.114
, pp. 1193-1201
-
-
Antoniades, C.1
Shirodaria, C.2
Warrick, N.3
Cai, S.4
de Bono, J.5
Lee, J.6
-
31
-
-
34247578183
-
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease
-
Shirodaria C., Antoniades C., Lee J., Jackson C.E., Robson M.D., Francis J.M., et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 115 (2007) 2262-2270
-
(2007)
Circulation
, vol.115
, pp. 2262-2270
-
-
Shirodaria, C.1
Antoniades, C.2
Lee, J.3
Jackson, C.E.4
Robson, M.D.5
Francis, J.M.6
|