Prenatal developmental toxicity studies of inhaled methyl iodide vapor in rabbits reveal a susceptible window of exposure inducing late gestational fetotoxicity

Inhalation Toxicology

Volumn 21, Issue 6, 2009, Pages 449-461

  Nemec, M ^a   Sloter, E ^a   Stump, D ^a   Holson, J ^a   Kirkpatrick, D ^a   Kinzell, J ^b  

^a WIL RESEARCH LABORATORIES   (United States)

^b ARYSTA LIFESCIENCE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL RABBIT; FEMALE; FETOTOXICITY; FETUS DEATH; FETUS DEVELOPMENT; FETUS WEIGHT; NIDATION; NONHUMAN; ORGANOGENESIS; PREGNANCY OUTCOME; PRENATAL EXPOSURE; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANIMALS; FEMALE; FETAL DEATH; FETAL DEVELOPMENT; GESTATIONAL AGE; HYDROCARBONS, IODINATED; MATERNAL EXPOSURE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RABBITS; VOLATILIZATION;

ORYCTOLAGUS CUNICULUS;

EID: 70350610938     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802596876     Document Type: Article

References (21)

1. Appel, G.B., Galen, R., O'Brien, J., and Schoenfeldt, R. 1975. Methyl iodide intoxication. A case report. Ann. Intern. Med. 82(4):534-536.
2. AWA. 1966. The Animal Welfare Act, 7 U.S.C. 2131-2159 (9 CFR, chapter, I, subchapter, A, parts 1, 2, and 3). Public Law 89-544, amended by Pub. L. 91-579, Pub. L. 94-279, and Pub. L. 99-198. US Congress.
3. Chameides, W.L., and Davis, D.D. 1980. Iodine: Its possible role in tropospheric photochemistry. J. Geophys. Res. 85:7383-7398.
4. Dunnett, C.W. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
5. Hermouet, C., Garnier, R., Efthymiou, M., and Fournier, P. 1996. Methyl iodide poisoning: Report of two cases. Am. J. Ind. Med. 30(6):759-764.
6. Holson, J.F., Nemec, M.D., Stump, D.G., Kaufman, L.E., Lindström, P., and Varsho, B.J. 2005. Significance, reliability, and interpretation of developmental and reproductive toxicity study findings. In Developmental and reproductive toxicology: A practical approach, 2nd ed., ed. R.D. Hood, pp. 329-424. Boca Raton, FL: CRC Press.
7. Institute of Laboratory Animal Resources, Commission on Life Sciences, and the National Research Council. 1996. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press.
8. Kruskal, W.H., and Wallis, W.A. 1952. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 47:583-621.
9. MAFF. 1999. 11 Nousan Number 6283. Good laboratory practice standards. Tokyo: Japanese Ministry of Agriculture, Forestry and Fisheries.
10. MAFF. 2000. 12 Nousan Number 8147. Developmental toxicity testing guidelines. Tokyo: Japanese Ministry of Agriculture, Forestry and Fisheries.
11. Moore, R.M., and Groszko, W. 1999. Methyl iodide distribution in the ocean and fluxes to the atmosphere. J. Geophys. Res. 104:11163-11171.
12. Organisation for Economic Cooperation and Development. 1997. Principles of good laboratory practice, C(97)186/Final. Paris: Organisation for Economic Cooperation and Development.
13. Organisation for Economic Cooperation and Development. 2001. Test no. 414. Guidelines for the testing of chemicals. Prenatal developmental toxicity study. Paris: Organisation for Economic Cooperation and Development.
14. Schwartz, M.D., Obamwonyi, A.O., Thomas, J.D., Moorhead, J.F., and Morgan, B.W. 2005. Acute methyl iodide exposure with delayed neuropsychiatric sequelae: Report of a case. Am. J. Ind. Med. 47(6):550-556.
15. Singh, H.B., Salas, L.J., and Stiles, R.E. 1983. Methyl halides in and over the eastern Pacific (40°N-32°S). J. Geophys. Res. 88:3684-3690.
16. Sloter, E., Nemec, M., Stump, D., Holson, J., Kirkpatrick, D., Gargas, M., Kinzell, J., and Kaufman, J. 2009. Mode of action: Methyl iodide-induced fetal hypothyroidism implicated in late-stage L. fetal rabbit deaths. Inhal. Toxicol. 21:462-479.
17. Snedecor, G.W., and Cochran, W.G. 1989. One way classifications: analysis of variance. In Statistical methods, 8th ed., pp. 217-236. Ames: Iowa State University Press.
18. Stuckhardt, J.L., and Poppe, S.M. 1984. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratogen. Carcinogen. Mutagen. 4:181-188.
19. U.S. Environmental Protection Agency. 1989. Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Good Laboratory Practice Standards (GLPs) Final rule. 40 CFR Part 160. Available at: www.fda.gov.
20. U.S. Environmental Protection Agency. 1998. Health effects test guidelines for prenatal developmental toxicity study. OPPTS 870.3700. Available at: www.fda.gov.
21. Zhang, W., McGiffen, M.E. Jr., Becker, J.O., Ohr, H.D., Sims, J.J., and Campbell, S.D. 1998. Effect of soil physical factors on methyl iodide and methyl bromide. Pestic. Sci. 53:71-79.