Design and development of a highly macroporous silicone scaffold as a bioartificial pancreas for Type 1 diabetes

IFMBE Proceedings

Volumn 24, Issue , 2009, Pages 233-234

  Pedraza, E ^a,b   Fraker, C ^a,b   Brady, A C ^b   Stabler, C ^a,b  

^a University of Miami College of Engineering   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

Device; Diabetes; Matrices; Scaffold; Silicone

Indexed keywords

ADHESION PROTEINS; BIO-ARTIFICIAL PANCREAS; CELL LOADING; DEGREE OF POROSITY; DESIGN AND DEVELOPMENT; DEVICE; DIABETES; HUMAN ISLETS; IN-VIVO; INFLAMMATORY RESPONSE; ISLET TRANSPLANTATION; MACROPOROUS; MATRICES; MECHANICAL STRESS; NON-HUMAN PRIMATE; NUTRIENT DELIVERY; PANCREATIC ISLET; PARTICLE RATIOS; PARTICULATE LEACHING; SMALL ANIMAL MODEL; SOLVENT CASTING; SPATIAL DISTRIBUTION; STRUCTURAL SUPPORT; TYPE 1 DIABETES;

ADHESION; ANTIGEN-ANTIBODY REACTIONS; BIOCOMPATIBILITY; BIOMEDICAL ENGINEERING; CELL ADHESION; CELL DEATH; LEACHING; NUTRIENTS; SEEPAGE; SILICONES; SOIL MECHANICS; STRESSES;

SCAFFOLDS;

EID: 70350608440     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-01697-4_81     Document Type: Conference Paper

References (3)

1. Shapiro A.M., et al. (2006) International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355, pp 1318-30.
2. Moberg L., Johansson H., et al. (2002) Productions of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 360, pp 2039-2045.
3. Johansson H., et al. (2005) Tissue factor produced by the endocrine cells of the islets of langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 54, pp 1755-1762.